Acute effects of fenthion on certain oxidative stress biomarkers in various tissues of frogs (<i>Rana ridibunda</i>)

Kanter, Ahmet; Çelik, İsmail

doi:10.1177/0748233711412426

Cited by 11 publications

(8 citation statements)

References 31 publications

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“…Research has demonstrated that fenthion induced DNA damage and should be considered potentially hazardous to humans (Wu et al, 2011). Recent research by Kanter and Celik (2012) revealed that exposure of frogs to fenthion induced an increase in melondialdehyde (MDA) and antioxidant defense systems. The effect of fenthion on biochemical changes in Cirrhina mrigala (Israel and Sam, 2012), liver function and pigmentation (Muralidharan and Pillai, 2012) in Cyprinus carpio have been reported.…”

Section: Introductionmentioning

confidence: 99%

Fenthion induced toxicity and histopathological changes in gill tissue of freshwater African catfish, Clarias gariepinus (Burchell, 1822)

Somdare¹,

Nwani²,

Nwadinigwe³

et al. 2015

Afr. J. Biotechnol.

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Fenthion is an organophosphate pesticide commonly used in agriculture and public health for the control of insect pests. The present study investigated the toxic effect of fenthion and the histopathological alterations in the gill tissue of African catfish Clarias gariepinus. The 96 h LC 50 value of fenthion in C. gariepinus determined by probit analysis was found to be 39.97 mg/L. Fish exposed to different fenthion concentrations showed clinical signs such as erratic swimming, attempt to jump out of water, increased opercula frequencies, air gasping, mucus secretion followed by exhaustion and death. To evaluate the histopathological changes in the gill tissue, fish were exposed to 2.0, 4.0 and 8.0 mg/L corresponding to 1/20, 1/10 and 1/5 th , respectively of 96 h LC 50 of fenthion for 21 days and 7 days recovery. Gill disorder and fusion of the secondary lamellar were pronounced in all treatments. Alterations in gill structure exposed to the highest concentration were oedema, lifting of lamellar epithelia, destruction of gill architecture and lamellar fusion. From the findings, it can be deduced that fenthion-induced alterations are irreversible and therefore should be applied with caution in the environment so as to reduce its damage to aquatic organisms.

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Section: Introductionmentioning

confidence: 99%

Fenthion induced toxicity and histopathological changes in gill tissue of freshwater African catfish, Clarias gariepinus (Burchell, 1822)

Somdare¹,

Nwani²,

Nwadinigwe³

et al. 2015

Afr. J. Biotechnol.

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“…Research has demonstrated that fenthion increases DNA damage in humans and that it should be considered potentially hazardous (Wu et al 2011). Recent research by Kanter and Celik (2012) has revealed that marsh frogs Rana ridibunda exposed to fenthion had an increase in lipid peroxidation and antioxidant defense systems. Israel and Sam (2012) reported biochemical changes in some tissues of Mrigal Cirrhinus mrigala exposed to fenthion, while Altuntas and Delibas (2002) reported that fenthion caused liver damage in Wister albino rats (a strain of the brown rat Rattus norvegicus).…”

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confidence: 99%

Subchronic Exposure to Fenthion Induces Hematological Changes in Liver Tissue of African Catfish Clarias gariepinus

Nwani¹,

Somdare²,

Ukonze³

et al. 2016

J Aqua Anim Hlth

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In this study, African Catfish (also known as Sharptooth Catfish) Clarias gariepinus were exposed to sublethal concentrations of fenthion of 2.0, 4.0, and 8.0 mg/L for 21 d and allowed to recover for 7 d to investigate the potential for hematological changes. Whole blood was sampled on days 1, 7, 14, and 21 postexposure and after a 7-d recovery period. During exposure, fenthion caused a reduction in red blood cell counts, hemoglobin concentration, and packed cell volume. There was an increase in white blood cell counts but no significant difference in mean corpuscular hemoglobin concentration, mean corpuscular volume, and mean corpuscular hemoglobin. Both increases and decreases were observed in white blood cell differentials. After the 7-d recovery period, both increases and decreases were observed in the hematological parameters. These results reveal that sublethal concentrations of fenthion can cause hematological alterations in African Catfish and that the substance should be used with caution. Received October 20, 2015; accepted May 4, 2016.

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“…Sublethal concentrations of malathion (0.006 mg/L) induced intestinal degenerative changes of the absorptive surface (villi) of the intestine of cricket frogs ( Fejervarya limnocharis ) at 10 d post exposure . Exposure of marsh frog ( Pelophylax ridibundus ) to 10 and 20 mg/L fenthion or dimethoate for 4 d increased malondialdehyde combined with a fluctuating antioxidant defense system, such as reduced glutathione levels and reduced glutathione peroxidase, glutathione‐S‐transferase, and superoxide dismutase activities in the liver, kidney, heart, and brain . Celik et al showed that the same doses of fenthion and dimethoate administed for 4 d caused fluctuations in brain acetylcholinesterase and butyrylcholinesterase activities, in addition to increased tissue myeloperoxidase, which was indicative of immunotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of an acute oral gavage method for assessment of pesticide toxicity in terrestrial amphibians

Fort

Mathis

Kee³

et al. 2017

Enviro Toxic and Chemistry

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Development of an acute oral toxicity test with a terrestrial-phase amphibian was considered necessary to remove the uncertainty within the field of agrochemical risk assessments. The bullfrog (Lithobates catesbeianus) was selected for use as it is a representative of the family Ranidae and historically this species has been used as an amphibian test model species. Prior to definitive study, oral gavage methods were developed with fenthion and tetraethyl pyrophosphate. Dimethoate and malathion were subsequently tested with both male and female juvenile bullfrogs in comprehensive acute oral median lethal dose (LD50) studies. Juvenile bullfrogs were administered a single dose of the test article via oral gavage of a single gelatin capsule of dimethoate technical (dimethoate) or neat liquid Fyfanon Technical (synonym malathion), returned to their respective aquaria, and monitored for survival for 14 d. The primary endpoint was mortality, whereas behavioral responses, food consumption, body weight, and snout-vent length (SVL) were used to evaluate indications of sublethal toxicity (secondary endpoints). Acute oral LD50 values (95% fiducial interval) for dimethoate were 1459 (1176-1810, males) and 1528 (1275-1831, females), and for malathion they were 1829 (1480-2259, males) and 1672 (1280-2183, females) mg active substance/kg body weight, respectively. Based on the results of these studies, the methodology for the acute oral gavage administration of test items to terrestrial-phase amphibians was demonstrated as being a practical method of providing data for risk assessments. Environ Toxicol Chem 2018;37:436-450. © 2017 SETAC.

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Acute effects of fenthion on certain oxidative stress biomarkers in various tissues of frogs (Rana ridibunda)

Cited by 11 publications

References 31 publications

Fenthion induced toxicity and histopathological changes in gill tissue of freshwater African catfish, Clarias gariepinus (Burchell, 1822)

Fenthion induced toxicity and histopathological changes in gill tissue of freshwater African catfish, Clarias gariepinus (Burchell, 1822)

Subchronic Exposure to Fenthion Induces Hematological Changes in Liver Tissue of African Catfish Clarias gariepinus

Evaluation of an acute oral gavage method for assessment of pesticide toxicity in terrestrial amphibians

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