Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers

Kerr, Danièle M I; Brooksbank, Katriona; Taylor, Richard G.; Pinel, Karine; Ríos, Francisco; Touyz, Rhian M.; Delles, Christian

doi:10.1097/hjh.0000000000001890

Cited by 62 publications

(64 citation statements)

References 41 publications

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“…2, where the vertical dashed line represents no effect and plots to the right of the vertical dashed line indicate that the TC effect is greater than the EC effect. The results of most studies [5,15,26,44,52], but not of all studies [16,25,47], are consistent with the concept that the effects of TC smoking on acute cardiovascular autonomic functions are greater than those of EC vaping. The overall mean differences between TC smoking and EC vaping across all studies was 1.58 mmHg (95% confidence interval [CI] 0.20-2.97; p = 0.025) for SBP, 1.57 mmHg (95% CI 0.37-2.78; p = 0.01) for DBP and 3.06 bpm (95% CI 2.01-4.10; p = 0.00001) for HR.…”

Section: Acute Autonomic Cardiovascular Effects Of Tc Smoking Versus supporting

confidence: 56%

“…Further, the sympathoexcitatory effects of acute EC use are largely attributable to nicotine-and not to the non-nicotine constituents in EC emissions [2,8,16,34]. Additionally, these sympathoexcitatory effects of acute EC vaping are less than those of acute TC smoking, as estimated by HR and BP [5,15,16,25,26,44,47,52]. Finally, limited data suggest that chronic EC use is associated with sympathetic activation [35], even in the absence of acute nicotine inhalation, although more data are needed for confirmation.…”

Section: Discussionmentioning

confidence: 99%

“…Kerr et al [26] performed a randomized crossover study in 20 chronic TC who smoked a TC and vaped an EC with 18 mg/ml of nicotine in random order. The increase in HR and SBP, but not DBP, was significantly greater after smoking the TC compared to vaping the EC [26]. Plasma nicotine levels were not measured.…”

Section: Acute Autonomic Cardiovascular Effects Of Tc Smoking Versus mentioning

confidence: 99%

“…Plasma nicotine levels in EC vapers are similar to those in TC smokers [42,49], and nicotine is a sympathomimetic agent. Several recent studies have reported that ECs, similar to TCs, increase sympathetic nerve activity, as estimated by acute and chronic changes in HR, BP and HRV [2,5,8,15,16,26,34,35,44,47,52].…”

Section: Introductionmentioning

confidence: 99%

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Cardiovascular autonomic effects of electronic cigarette use: a systematic review

2020

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Purpose Electronic cigarettes (ECs) are the fastest growing tobacco product in the USA, and ECs, like tobacco cigarettes (TCs), have effects on the cardiovascular autonomic nervous system, with clinical implications. The purpose of this review was to collect and synthesize available studies that have investigated the autonomic cardiovascular effects of EC use in humans. Special attention is paid to the acute and chronic effects of ECs, the relative contributions of the nicotine versus non-nicotine constituents in EC emissions and the relative effects of ECs compared to TCs. Methods Using the methodology described in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement, we conducted a literature search of the Ovid PubMed and Embase databases on 6 December 2019 using keywords in titles and abstracts of published literature. Acute (minutes to hours) and chronic (days or longer) changes in heart rate variability (HRV), heart rate (HR) and blood pressure (BP) were used as estimates of cardiovascular autonomic effects. Results Nineteen studies were included in this systematic review, all of which used earlier generation EC devices. Acute EC vaping increased HR and BP less than acute TC smoking. Nicotine but not non-nicotine constituents in EC aerosol were responsible for the sympathoexcitatory effects. The results of chronic EC vaping studies were consistent with a chronic sympathoexcitatory effect as estimated by HRV, but this did not translate into chronic increases in HR or BP. Conclusions Electronic cigarettes are sympathoexcitatory. Cardiac sympathoexcitatory effects are less when vaping using the earlier generation ECs than when smoking TCs. Additional studies of the latest pod-like EC devices, which deliver nicotine similarly to a TC, are necessary.

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Section: Acute Autonomic Cardiovascular Effects Of Tc Smoking Versus supporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Acute Autonomic Cardiovascular Effects Of Tc Smoking Versus mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardiovascular autonomic effects of electronic cigarette use: a systematic review

2020

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“…In the present study we investigate whether e-cigarette use may cause similar vascular effects as demonstrated following cigarette smoking, as we and other groups have previously demonstrated [19,20]. Moreover, we investigate if nicotine is the main component for the adverse vascular effects.…”

Section: Introductionmentioning

confidence: 79%

Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteers

et al. 2020

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The vascular effects of e-cigarettes with and without nicotine were investigated in healthy volunteers. • Circulating extracellular vesicles (EVs) of endothelial and platelet origin were assessed. • Thirty puffs of nicotine-containing e-cigarette vapor caused an increase in EVs of endothelial and platelet origin. • Following exposure to e-cigarettes without nicotine only platelet derived EVs expressing CD40 ligand were increased. • E-cigarettes cause stress to endothelial and platelet cells similar to what has been observed following cigarette smoking.

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Epigenetic Influences of Air Pollution-Induced Cardiac Arrhythmias

O’Piela,

Grimmer,

Schwieterman

et al. 2023

Heart Rate and Rhythm

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Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers

Cited by 62 publications

References 41 publications

Cardiovascular autonomic effects of electronic cigarette use: a systematic review

Cardiovascular autonomic effects of electronic cigarette use: a systematic review

Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteers

Epigenetic Influences of Air Pollution-Induced Cardiac Arrhythmias

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