Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteers

Mobarrez, Fariborz; Antoniewicz, Lukasz; Hedman, Linnéa; Bosson, Jenny A.; Lundbäck, Magnus

doi:10.1016/j.atherosclerosis.2020.02.010

Cited by 44 publications

(31 citation statements)

References 54 publications

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“…Corsello et al also showed airway epithelial cells exposed to environmental tobacco smoke displayed an increase in EV size that further lead to enhanced EV cargo content [49]. Furthermore, a recent study examining the effects of e-cigarettes containing nicotine revealed an increase in endothelial and platelet-derived EVs in healthy volunteers [50]. Our current observation that chronic nicotine treatment caused an increase in both BDEV concentration and size in males and females further bolsters these above-mentioned studies.…”

Section: Discussionsupporting

confidence: 80%

Role of Brain Derived Extracellular Vesicles in Decoding Sex Differences Associated with Nicotine Self-Administration

Koul

Schaal

Chand

et al. 2020

Cells

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Smoking remains a significant health and economic concern in the United States. Furthermore, the emerging pattern of nicotine intake between sexes further adds a layer of complexity. Nicotine is a potent psychostimulant with a high addiction liability that can significantly alter brain function. However, the neurobiological mechanisms underlying nicotine’s impact on brain function and behavior remain unclear. Elucidation of these mechanisms is of high clinical importance and may lead to improved therapeutics for smoking cessation. To fill in this critical knowledge gap, our current study focused on identifying sex-specific brain-derived extracellular vesicles (BDEV) signatures in male and female rats post nicotine self-administration. Extracellular vesicles (EVs) are comprised of phospholipid nanovesicles such as apoptotic bodies, microvesicles (MVs), and exosomes based on their origin or size. EVs are garnering significant attention as molecules involved in cell–cell communication and thus regulating the pathophysiology of several diseases. Interestingly, females post nicotine self-administration, showed larger BDEV sizes, along with impaired EV biogenesis compared to males. Next, using quantitative mass spectrometry-based proteomics, we identified BDEV signatures, including distinct molecular pathways, impacted between males and females. In summary, this study has identified sex-specific changes in BDEV biogenesis, protein cargo signatures, and molecular pathways associated with long-term nicotine self-administration.

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Section: Discussionsupporting

confidence: 80%

Role of Brain Derived Extracellular Vesicles in Decoding Sex Differences Associated with Nicotine Self-Administration

Koul

Schaal

Chand

et al. 2020

Cells

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“…The one study that assessed HR variability found a sympathetic predominance in those individuals exposed to e-cigarettes containing nicotine, a pattern associated with increased cardiac risk in populations with and without known cardiovascular disease (Moheimani et al 2017). A similar cross-over study by Mobarrez et al (2020) observed increased platelet and endothelial derived extracellular vesicles 4 h following exposure to inhalation of e-cigarettes with nicotine, which is consistent with activation of platelets by acute e-cigarette exposure. In another crossover study (Chaumont et al 2018), occasional smokers were randomized to short-term (acute) exposure to high-wattage nicotine-free e-cigarette use, e-cigarette use with nicotine and sham use.…”

Section: Acute Exposures (Max 60 Min)mentioning

confidence: 76%

Effects of e‐cigarettes and vaping devices on cardiac and pulmonary physiology

Tsai

Byun

Shin

et al. 2020

The Journal of Physiology

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Short term • Increased flow resistance • Increased airway reactivity Long term • Emphysema • Higher airway resistance • Airway onstruction • Airway inflammation Short term • Increased heart rate • Increased blood pressure • Increased aortic stiffness Long term • Increased atherosclerosis • Increased aortic stiffness Abstract E-cigarette aerosols are exceedingly different from conventional tobacco smoke, containing dozens of chemicals not found in cigarette smoke. It is highly likely that chronic use of e-cigarettes will induce pathological changes in both the heart and lungs. Here we review human and animal studies published to date and summarize the cardiopulmonary physiological changes

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“…Interestingly, CD40 expression on plate-derived EVs was also increased by e-cigarette vapor that did not contain nicotine. The study concluded that as few as 30 puffs from a nicotine-containing e-cigarette caused an increase in circulating EVs that originated from endothelial or platelet cells, and nicotine, as a component of the vapor, affects EV formation and protein composition [130].…”

Section: Nicotinementioning

confidence: 99%

“…With the increasing use of electronic cigarettes (e-cigarettes), it is important to understand how this form of smoking may affect EVs and their cargoes. A recent study found that platelet- and endothelial-derived EVs were increased 4 h after active inhalation of e-cigarette vapor with nicotine [ 130 ]. Further, platelet-derived EVs expressing P-selectin, a platelet activation marker, and CD40, an inflammation marker, were significantly increased following inhalation of e-cigarette vapor with nicotine.…”

Section: Drugs Of Abusementioning

confidence: 99%

Role of Extracellular Vesicles in Substance Abuse and HIV-Related Neurological Pathologies

Odegaard

Chand

Wheeler

et al. 2020

IJMS

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Extracellular vesicles (EVs) are a broad, heterogeneous class of membranous lipid-bilayer vesicles that facilitate intercellular communication throughout the body. As important carriers of various types of cargo, including proteins, lipids, DNA fragments, and a variety of small noncoding RNAs, including miRNAs, mRNAs, and siRNAs, EVs may play an important role in the development of addiction and other neurological pathologies, particularly those related to HIV. In this review, we summarize the findings of EV studies in the context of methamphetamine (METH), cocaine, nicotine, opioid, and alcohol use disorders, highlighting important EV cargoes that may contribute to addiction. Additionally, as HIV and substance abuse are often comorbid, we discuss the potential role of EVs in the intersection of substance abuse and HIV. Taken together, the studies presented in this comprehensive review shed light on the potential role of EVs in the exacerbation of substance use and HIV. As a subject of growing interest, EVs may continue to provide information about mechanisms and pathogenesis in substance use disorders and CNS pathologies, perhaps allowing for exploration into potential therapeutic options.

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Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteers

Cited by 44 publications

References 54 publications

Role of Brain Derived Extracellular Vesicles in Decoding Sex Differences Associated with Nicotine Self-Administration

Role of Brain Derived Extracellular Vesicles in Decoding Sex Differences Associated with Nicotine Self-Administration

Effects of e‐cigarettes and vaping devices on cardiac and pulmonary physiology

Role of Extracellular Vesicles in Substance Abuse and HIV-Related Neurological Pathologies

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