Acute effects of benzo[a]pyrene on digestive gland enzymatic biomarkers and DNA damage on mussel Mytilus galloprovincialis

Transcriptional regulation of selenium-dependent glutathione peroxidase from Venerupis philippinarum in response to pathogen and contaminants challenge

“…For example, V. anguillarum is found to be one of the major pathogens causing vibriosis in China [19]. Moreover, numerous environmental pollutants such as heavy metals and persistent organic chemicals are increasingly entering the aquatic systems which have the potential to cause oxidative stress in aquatic organisms [3,27,28]. The identification and characterization , ABP73388), U. tumidus (Unio tumidus, ABH10623), H. discus hannai (Haliotis discus hannai, ADD71075), S. scrofa GPx6 (Sus scrofa, ABO26604), X. laevis GPx3 (Xenopus laevis, NP_001036994), C. gigas (Crassostrea gigas, ABS19600).…”

“…The polycyclic aromatic hydrocarbons (PAH) such as B[a]P are environmental contaminants considered as stress agents responsible for biological and physiological alterations in living species [28], which is commonly found in the coastal waters of southeast China [23]. A number of studies have described B[a]P induction of metabolizing enzymes [12,28].…”

“…A number of studies have described B[a]P induction of metabolizing enzymes [12,28]. However, the relationship between B[a]P exposure and GPx transcription is not as much studied.…”

Molecular cloning and differential expression patterns of sigma and omega glutathione S-transferases from Venerupis philippinarum to heavy metals and benzo[a]pyrene exposure

“…These fi ndings highlighted the fact that specifi c GSTs response may vary with species and concentrations of toxicant (Blanchette et al, 2007). B[a]P, as a potent carcinogen and/or mutagen, is usually oxidized by phase I mixed function oxidases to yield electrophilic intermediates, which are still toxic or become even more toxic in many cases (Wan et al, 2008b;Banni et al, 2010). As the most important phase II enzymes, GSTs have been extensively investigated as biomarkers for ecotoxicological assessment of organic pollutants (Boutet et al, 2004;Wan et al, 2008aWan et al, , 2008bWan et al, , 2009Park et al, 2009;Banni et al, 2010).…”

Expression profiles of seven glutathione S-transferase (GST) genes from Venerupis philippinarum exposed to heavy metals and benzo[a]pyrene

“…Our results suggested that VpGSTs displayed particularly high sensitivity to B[a]P exposure. Previous studies have also revealed that B[a]P exposure could induce GST activity and the expression of mRNA in Mytilus galloprovincialis (Hoarau et al, 2006;Banni et al, 2010) and V. philippinarum (Xu et al, 2010). Therefore, changes in VpGSTs expression observed in V. philippinarum exposed to B[a]P indicated that VpGSTs may have a defensive role against B[a]P toxicity.…”