Acute effects of an arginine-based supplement on neuromuscular, ventilatory, and metabolic fatigue thresholds during cycle ergometry

Abstract

The purpose of the present study was to examine the effects of an acute dose of an arginine-based supplement on the physical working capacity at the fatigue threshold (PWCFT), lactate threshold (LT), ventilatory threshold (VT), and peak oxygen uptake during incremental cycle ergometry. This study used a double-blinded, placebo-controlled, within-subjects crossover design. Nineteen untrained men (mean age ± SD = 22.0 ± 1.7 years) were randomly assigned to ingest either the supplement (3.0 g of arginine, 300 mg of grape seed extract, and 300 mg of polyethylene glycol) or placebo (microcrystalline cellulose) and performed an incremental test on a cycle ergometer for determination of PWCFT, LT, VT, and peak oxygen uptake. Following a 1-week period, the subjects returned to the laboratory and ingested the opposite substance (either supplement or placebo) prior to completing another incremental test to be reassessed for PWCFT, LT, VT, and peak oxygen uptake. The paired-samples t tests indicated there were significant (P < 0.05) mean differences between the arginine and placebo conditions for the PWCFT (192 ± 42 vs. 168 ± 53 W, respectively) and VT (2546 ± 313 vs. 2452 ± 342 mL·min(-1)), but not the LT (135 ± 26 vs. 138 ± 22 W), absolute peak oxygen uptake (3663 ± 445 vs. 3645 ± 438 mL·min(-1)), or relative peak oxygen uptake (46.5 ± 6.0 vs. 46.2 ± 5.0 mL·kg(-1)·min(-1)). These findings suggested that the arginine-based supplement may be used on an acute basis for delaying the onset of neuromuscular fatigue (i.e., PWCFT) and improving the VT in untrained individuals.

Cycle ergometer training vs resistance training in ICU‐acquired weakness

“…17 Participants exercised on a wheelchair ergometer (MOTOmed Reck). 17 Participants exercised on a wheelchair ergometer (MOTOmed Reck).…”

“…Cardiovascular endurance and muscular endurance of the lower extremities were tested using the physical working capacity of the fatigue threshold test (PWC FT ). 17 Participants exercised on a wheelchair ergometer (MOTOmed Reck). They started with minimum pedal resistance.…”

Acute Effects Of A Multi-ingredient Pre-workout Supplement On 5-km Running Performance In Recreationally-trained Athletes

“…The authors (47) reported that compared to the placebo, the pre-workout supplement led to increased time to exhaustion (+12.5%) at 70% V̇O2max, while improving feelings of energy and focus. These findings may be attributable to caffeine, betaalanine, and arginine found within the investigated product and many other pre-workouts that have been shown to delay the onset of fatigue and reduce feelings of exertion (4,11,15,28,30,39,41,42,48). Consistent with many pre-workouts on the market, however, the product of Walsh et al (47) contained proprietary blends with the majority of ingredients (including caffeine) listed at unknown quantities.…”

A Monocentric Randomized, Double-Blind, Placebo-Controlled Trial on the Effectiveness of Bioarginina® in Oral Administration for the Treatment of Asthenia in Patients without Associated Comorbidities

“…Arginine is a conditionally essential amino acid that is involved in protein synthesis, the detoxification of ammonia, and its conversion to glucose as well as being catabolized to produce energy; in addition to these physiological functions, arginine has shown to have ergogenic potential [4]. Argininebased supplement may be used on an acute basis for delaying the onset of neuromuscular fatigue (i.e., PWCFT) and improving the ventilatory threshold [5].…”