Acute effects of alcohol on regional cerebral blood flow in man.

Sano, Masaaki; Wendt, P.; Wirsén, Ann; Stenberg, Georg; Risberg, Jarl; Ingvar, David H.

doi:10.15288/jsa.1993.54.369

Cited by 72 publications

(58 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…administration [18][19][20][21], but on the other hand, a hyperalgesic effect can also be induced by systemic or intracerebroventricular administration [22]. Human and animal studies have respectively demonstrated that cerebral blood flow [23][24][25] and c-Fos immunoreactivity [26,27] in the PFC are significantly increased after acute alcohol administration. Moreover, the systemic effects of ethanol on behavior can be significantly reversed by disrupting the function of the mPFC [28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Ethanol Increases Mechanical Pain Sensitivity in Rats via Activation of GABAA Receptors in Medial Prefrontal Cortex

Geng

Wang

et al. 2016

Neurosci. Bull.

View full text Add to dashboard Cite

Ethanol is widely known for its ability to cause dramatic changes in emotion, social cognition, and behavior following systemic administration in humans. Human neuroimaging studies suggest that alcohol dependence and chronic pain may share common mechanisms through amygdala-medial prefrontal cortex (mPFC) interactions. However, whether acute administration of ethanol in the mPFC can modulate pain perception is unknown. Here we showed that bilateral microinjections of ethanol into the prelimbic and infralimbic areas of the mPFC lowered the bilateral mechanical pain threshold for 48 h without influencing thermal pain sensitivity in adult rats. However, bilateral microinjections of artificial cerebrospinal fluid into the mPFC or bilateral microinjections of ethanol into the dorsolateral PFC (also termed as motor cortex area 1 in Paxinos and Watson's atlas of The Rat Brain. Elsevier Academic Press, Amsterdam, 2005) failed to do so, suggesting regional selectivity of the effects of ethanol. Moreover, bilateral microinjections of ethanol did not change the expression of either pro-apoptotic (caspase-3 and Bax) or anti-apoptotic (Bcl-2) proteins, suggesting that the dose was safe and validating the method used in the current study. To determine whether c-aminobutyric acid A (GABA A ) receptors are involved in mediating the ethanol effects, muscimol, a selective GABA A receptor agonist, or bicuculline, a selective GABA A receptor antagonist, was administered alone or co-administered with ethanol through the same route into the bilateral mPFC. The results showed that muscimol mimicked the effects of ethanol while bicuculline completely reversed the effects of ethanol and muscimol. In conclusion, ethanol increases mechanical pain sensitivity through activation of GABA A receptors in the mPFC of rats.

show abstract

Section: Introductionmentioning

confidence: 99%

Ethanol Increases Mechanical Pain Sensitivity in Rats via Activation of GABAA Receptors in Medial Prefrontal Cortex

Geng

Wang

et al. 2016

Neurosci. Bull.

View full text Add to dashboard Cite

show abstract

“…Whereas a number of studies have examined the effects of acute alcohol consumption on CBF in non-alcoholics (e.g., Sano et al, 1993;Volkow et al, 1998), to our knowledge, only a single study has investigated the effect of routine alcohol intake on CBF in a sober state and demonstrated an inverse relationship between alcohol consumption and gray matter blood flow (Rogers et al, 1983). One potential methodological shortcoming of the Rogers et al study is the use of the [ 133 Xe] Xenon inhalation method (Obrist et al, 1975;Obrist and Wilkinson, 1990) which is limited by low spatial resolution and less reliable quantitative measures compared to other imaging methods (Cherry and Phelps, 2002).…”

Section: Introductionmentioning

confidence: 99%

Alcohol consumption and cerebral blood flow among older adults

Christie

Price

Edwards

et al. 2008

Alcohol

View full text Add to dashboard Cite

A substantial epidemiological literature now supports the existence of a J-or U-shaped association between alcohol consumption and a broad range cardiovascular health outcomes including stroke. Although it is well documented that alcoholics exhibit both global and regional cerebral hypoperfusion in the sober state, little is known regarding the effects of a broader range of alcohol consumption on cerebral blood flow (CBF). The present study employed positron emission tomography with H 2 15 O to assess quantitative global and regional CBF in 86 participants (51 men and 35 women; mean age 60.1) as a function of self-reported weekly alcohol consumption (none, <1, 1 to <7, 7 to <15, and >15 drinks per week). Analyses controlling for age, gender, and vascular health (carotid intima-media thickness) revealed that, relative to the weighted population mean, global CBF was greater in the lightest alcohol consumption group (<1 per week) and lower in the heaviest (>15 per week). Effects did not vary across regions of interest. This report is the first to describe an inverted J-shaped relationship between alcohol consumption and CBF in the absence of stroke.

show abstract

“…Several investigations of normal, healthy subjects have revealed that moderate ethanol inebriation is followed by a global increase in cerebral blood flow (CBF) during rest (Mathew & Wilson, 1986;Newlin, Golden, Quaife, & Graber, 1982;Sano et al, 1993). Most likely this is caused by a global vasodilatatory effect of ethanol (Greenberg et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

“…Most likely this is caused by a global vasodilatatory effect of ethanol (Greenberg et al, 1993). Doses of 0.7 and 1.5 g alcohol/kg of body weight caused average increases of CBF by 12 and 16%, respectively (Sano et al, 1993). During normal conditions the regional cerebral blood flow (rCBF) is tightly coupled to the function and oxygen and glucose metabolism of the brain (Edvinsson, Mackenzie, & McCulloch, 1993;Raichle, Grubb, Gado, Eichling, and Ter-Pogossian, 1976).…”

Section: Introductionmentioning

confidence: 99%