Acute effects of administered calcitonin in man

Fr, Singer; Gv, Foster; Gf, Jpolin; Nadarajah, A; Dk, Parkinson; Thalassinos, N. C.; Nj, Woodhouse; Mb, Clark; Tr, Fraser; MacIntyre, I.

doi:10.1007/bf02065202

Cited by 12 publications

(12 citation statements)

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“…Acute clearance studies, each lasting approximately 6-8 h, were performed on female mongrel dogs weighing [16][17][18][19][20][21][22] kg which had been thyroparathyroidectomized (TPTX) at least 3 days before their use in an experimental study. Completeness of glandular ablation was confirmed by a postoperative decline in serum calcium concentration of at least 30%o, and thyroid hormone was replaced as synthroid, 0.3 mg/day by mouth.…”

Section: Methodsmentioning

confidence: 99%

Study of the Renal Tubular Interactions of Thyrocalcitonin, Cyclic Adenosine 3′, 5′ -Monophosphate, 25-Hydroxycholecalciferol, and Calcium Ion

Puschett¹,

Beck²,

Jelonek³

et al. 1974

J. Clin. Invest.

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A B S T R A C T Acute clearance studies were performed in thyroparathyroidectomized animals to determine the actions and interactions of thyrocalcitonin (TCT), cyclic adenosine 3'5'-monophosphate (cAMP), 25-hydroxycholecalciferol (25HCC), and calcium ion on the reabsorption of phosphate, calcium, sodium, and potassium by the kidney. The infusion of 25HCC in a dosage of 60 U/h to moderately saline-expanded animals (2.5% body weight) induced a fall in the excretion of all of the ions under study after 90-120 min similar to that observed in previous experiments from this laboratory. Mean decrements in fractional excretion were: phosphate, 42.0% (P < 0.005); calcium, 25.0% (P < 0.005); sodium, 23.4% (P < 0.001); and potassium, 14.7% (P < 0.005). The superimposition of either porcine or salmon TCT (1-100 MRC U/h for 2 h) resulted in no further alterations in electrolyte excretion. However, the infusion of TCT during steady-state saline expansion, before the administration of 25HCC, obviated the renal transport effects of the vitamin D metabolite. Both in the latter studies, as well as those in whiicl similar doses of TCT were given to hydropenic animnals, the hormone itself failed to induce any consistent alteration in electrolyte excretion. Cyclic AMP (50 mg/h) caused an increase in the excretion of phosphate, sodium, and potassium and no change in calcium excretion. Like TCT, the nucleotide blocked the action of 25HCC on the kidney. Raising the mean level of serum ultrafilterable calcium to 3.02±0.25 mEq/liter from 1.62±0

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Section: Methodsmentioning

confidence: 99%

Study of the Renal Tubular Interactions of Thyrocalcitonin, Cyclic Adenosine 3′, 5′ -Monophosphate, 25-Hydroxycholecalciferol, and Calcium Ion

Puschett¹,

Beck²,

Jelonek³

et al. 1974

J. Clin. Invest.

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“…The acute administration of porcine or salmon calcitonin has been shown to cause an increase in urinary calcium and sodium in the saline loaded rat [6] and in normal subjects and patients with hypoparathyroidism [47,176,203]. The effect of calcitonin on urinary magnesium was variable: it decreased in the rat [6] and either increased [176,203] or remained unchanged in man [47].…”

Section: Calcitoninmentioning

confidence: 99%

“…The effect of calcitonin on urinary magnesium was variable: it decreased in the rat [6] and either increased [176,203] or remained unchanged in man [47]. There may be species differences in the renal actions of calcitonin in that no effect on electrolyte excretion could be demonstrated in the dog [40].…”

Section: Calcitoninmentioning

confidence: 99%

The Hormonal and Non-Hormonal Control of Renal Excretion of Calcium and Magnesium

Massry¹,

Jw²

1973

Nephron

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This report reviews the various hormonal and non-hormonal factors involving the renal handling of calcium and magnesium and the effect of these factors on the relationship between the excretions of these divalent ions and that of sodium. Among the factors discussed are: (1) extracellular volume expansion, (2) renal vasodilatation, (3) changes in glomerular filtration rate, Parathyroid hormone (4) hypercalcemia and hypermagnesemia, (5) diuretics, (6) phosphate depletion and loading, (7) alterations in acid base balance, (8) diet, (9) fasting, (10) activity, (11) diurnal variation, and (12) various hormones including parathyroid hormone, calcitonin, vitamin D, growth hormone, thyroid hormone, and adrenal steroids.

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“…Others [18,55] have found no such effects or only after a very large dose [61]. In man, calciuria and phosphaturia have been observed after the administration of large doses of porcine calcitonin [7,64]. In a similar study using synthetic human calcitonin, Woodhouse el al.…”

Section: Calcitoninmentioning

confidence: 78%

“…In normal man and patients with mild osteoporosis however, injection of large doses of porcine [11,26,64] and human calcitonin [70] (fig. 6) causes little or no fall in plasma calcium.…”

Section: Calcitoninmentioning

confidence: 99%

Regulation of Plasma Calcium in Man: The Influence of Parathyroid Hormone and Calcitonin

Gudmundsson¹,

Woodhouse²

1971

Horm Res Paediatr

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Acute effects of administered calcitonin in man

Cited by 12 publications

References 0 publications

Study of the Renal Tubular Interactions of Thyrocalcitonin, Cyclic Adenosine 3′, 5′ -Monophosphate, 25-Hydroxycholecalciferol, and Calcium Ion

Study of the Renal Tubular Interactions of Thyrocalcitonin, Cyclic Adenosine 3′, 5′ -Monophosphate, 25-Hydroxycholecalciferol, and Calcium Ion

The Hormonal and Non-Hormonal Control of Renal Excretion of Calcium and Magnesium

Regulation of Plasma Calcium in Man: The Influence of Parathyroid Hormone and Calcitonin

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