Acute Effect of High-Intensity Eccentric Exercise on Vascular Endothelial Function in Young Men

Choi, Youngju; Akazawa, Nobuhiko; Zempo-Miyaki, Asako; Ra, Song‐Gyu; Shiraki, Hitoshi; Ajisaka, Ryuichi; Maeda, Seiji

doi:10.1519/jsc.0000000000000536

Cited by 27 publications

(21 citation statements)

References 53 publications

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“…These suggest that the muscle damage induced ECC1 did not affect the changes in baPWV. As described above, previous studies have shown that arterial stiffness increased after eccentric exercise that induced muscle damage (Barnes et al 2010;Burr et al 2015;Choi et al 2016;Lin et al 2017). However, no significant changes in baPWV were evident at any time point after ECC1.…”

Section: Mvc Torquementioning

confidence: 73%

Changes in arterial stiffness after eccentric versus concentric cycling

Okamoto

Kobayashi

Hashimoto

et al. 2019

Appl. Physiol. Nutr. Metab.

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This study compared changes in brachial-ankle pulse wave velocity (baPWV) after concentric (CON) versus eccentric (ECC) cycling. It was hypothesized that baPWV would increase after the first ECC bout (ECC1) because of muscle damage, but not after the second ECC bout (ECC2), and would decrease after CON. Fifteen young (aged 20–30 years) men performed 2 bouts of 30-min ECC (ECC1 and ECC2) at 60% of maximal CON power output and 2 bouts of 30-min CON at the same intensity as that of ECC (CON1), and at the same oxygen consumption as that of ECC (CON2) every 2 weeks. Oxygen uptake during the cycling was recorded, and baPWV was measured before and at 0.5, 1, 24, and 48 h after each cycling bout. Maximal voluntary contraction (MVC) torque and muscle soreness of the knee extensors were assessed before and at 24 and 48 h after each cycling bout. Changes in these variables over time were compared among the 4 cycling bouts by 2-way repeated-measured ANOVA. baPWV decreased (P < 0.05) 8% from the baseline (1119 ± 116 cm/s) at 0.5 h after CON1 (1028 ± 126 cm/s), but no significant changes were evident after ECC1, ECC2, and CON2. MVC torque decreased 10% from the baseline at 24 h after ECC1, but no significant changes were evident after CON1, CON2, and ECC2. These results did not support the hypothesis, and suggest that minor muscle damage induced by eccentric cycling does not affect arterial stiffness.

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Section: Mvc Torquementioning

confidence: 73%

Changes in arterial stiffness after eccentric versus concentric cycling

Okamoto

Kobayashi

Hashimoto

et al. 2019

Appl. Physiol. Nutr. Metab.

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“…higher exercise-induced inflammation [3,9,35]. During ECC arm cycling, increased systemic vascular resistance has also been reported [5].…”

Section: Introductionmentioning

confidence: 92%

Cardiorespiratory and Autonomic Nervous System Responses to Prolonged Eccentric Cycling

Ritter

Isacco²,

Rakobowchuk

et al. 2019

Int J Sports Med

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Offering large muscle benefits despite low metabolic demand, continuous eccentric exercise appears to be an interesting alternative to concentric exercise. Nevertheless, further knowledge is needed about prolonged eccentric exercise. This work sought to investigate the cardiovascular responses to prolonged constant-load eccentric compared to concentric cycling. Ten healthy males performed two 45-min exercise sessions of either concentric or eccentric cycling separated by a month and matched for heart rate during the first 5 min of exercise. Cardiorespiratory, autonomic nervous system and vascular responses were assessed at rest, and during exercise and recovery. During cycling, oxygen uptake, cardiac output and systolic blood pressure were similar but heart rate and diastolic blood pressure were greater whereas stroke volume was lower during eccentric than concentric cycling (118±21 vs. 104±10 bpm; 77±9 vs. 65±8 mmHg; 122±12 vs. 135±13 mL). Baroreflex and noradrenaline concentration were altered during eccentric cycling, and after eccentric exercise, vascular tone was greater than after concentric cycling. We observed increased cardiovascular strain and altered baroreflex activity during eccentric compared with concentric exercise, suggesting eccentric cycling triggers greater sympathetic activity.

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“…Therefore, there is a need to determine the clinical impact of different modes of exercise (including resistance exercise) on vascular function in woman since (1) young women suffer a disproportionate burden of morbidity and mortality attributable to obesity and have higher morbidity and mortality rates after myocardial infarction compared to men (Maas et al, 2011) and (2) intense exercise which may be experienced particularly in the initial stages of an exercise program may be harmful to blood vessel function. For example, acute high intensity resistance exercise (>80% 1RM) can reduce brachial FMD (Phillips et al, 2011; Choi et al, 2014). In contrast, moderate intensity, aerobic exercise (50–65% VO 2max ) has been shown to improve FMD in lean individuals (Rooks et al, 2011) or reduce FMD in overweight individuals (Harris et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Reduced vasodilator function following acute resistance exercise in obese women

et al. 2014

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Obesity contributes to stress induced impairments in endothelium-dependent vasodilation (EDV), a precursor to atherosclerosis. Since obesity is associated with inflammation and oxidative stress, we sought to determine if a single bout of strenuous weight lifting (SWL) reduces EDV among sedentary obese adults. Participants included 9 obese (OB) (BMI 30.0–40.0 kg/m2) and 8 lean (LN) (BMI 18.5–24.9 kg/m2) sedentary young women. All participants underwent a single bout of SWL using a progressive leg-press protocol. Brachial artery flow-mediated dilation (FMD) (an index of EDV) was determined using ultrasonography before and after SWL. Sublingual nitroglycerin (NTG) was used to determine brachial artery endothelium-independent vasodilation following SWL. Brachial artery FMD was significantly reduced in OB and LN women (LN: 6.4 ± 1.6%, p = 0.22) after SWL. There was no difference in the magnitude of change pre- and post-SWL between groups (OB: −2.4 ± 0.6% and LN: −2.2 ± 1.6%, p = 0.84). Dilation to NTG was lower in OB (21.6 ± 1.3%) compared to LN women (27.6 ± 2.1%, p = 0.02) and associated with body weight (r = −0.70, p = 0.01). These data suggest that EDV is reduced in woman after acute resistance exercise. Dilations to NTG were lower in obese compared to lean woman and associated with body weight suggesting that changes in sensitivity of blood vessels to NO occurs during obesity. These findings may be important for understanding vascular risk following acute exercise in obesity.

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Acute Effect of High-Intensity Eccentric Exercise on Vascular Endothelial Function in Young Men

Cited by 27 publications

References 53 publications

Changes in arterial stiffness after eccentric versus concentric cycling

Changes in arterial stiffness after eccentric versus concentric cycling

Cardiorespiratory and Autonomic Nervous System Responses to Prolonged Eccentric Cycling

Reduced vasodilator function following acute resistance exercise in obese women

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