Acute effect of an infusion of Montanoa tomentosa on despair-like behavior and activation of oxytocin hypothalamic cells in Wistar rats

Lagunes-Merino, Omar; Rodríguez‐Landa, Juan Francisco; Caba, Mario; Carro‐Juárez, Miguel; García-Orduña, Francisco; Saavedra-Vélez, Margarita Virginia; Puga-Olguín, Abraham; Rovirosa-Hernández, María de Jesús

doi:10.1016/j.jtcme.2019.01.005

Cited by 6 publications

(13 citation statements)

References 32 publications

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“…Present findings provide experimental evidence that the crude extract preparation of M. tomentosa, used as a traditional remedy, possesses aphrodisiac properties. [15][16][17][18][19] An important study was conducted in 2015 by the Pharmacological Department in Mexico, with the purpose to evaluate the effect of M. tomentosa lyophilisate on rat's anxiety-like behavior and to analyze its mechanism of action. 16 The anxiolytic-like action of M. tomentosa (1.5, 3.0, 6.0 and 12.0 mg/kg) was investigated in male Wistar rats tested in three animal models of anxiety: the burying behavior, the elevated plus maze and the hole-board tests.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

“…The results corroborate the anxiolytic-like actions of M. tomentosa and suggest that this effect is mediated through GABAA receptors but not oxytocin receptors. [16][17][18][19] It has been scientifically shown that the endocrine state could modify the antianxiety-like actions of anxiolytic compounds. A study was conducted to evaluate the effect of the aqueous extract of M. tomentosa in rats with long-term absence of ovarian hormones induced by ovariectomy.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

“…However, hormonal variations could induce the opposite effects, hence women should be cautious. [17][18][19] In 2019 the Instituto de Neuroetología (Universidad Veracruzana, Xalapa, Mexico) focused on the acute effect of an infusion of M. tomentosa on despair-like behavior and activation of oxytocin hypothalamic cells in Wistar rats. In pre-clinical research, both the extract and some of its active metabolites have produced oxytocinergic-like effects on female reproductive organs; 18 however, there are no detailed studies of its effects on mood state and brain structures.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

“…[17][18][19] In 2019 the Instituto de Neuroetología (Universidad Veracruzana, Xalapa, Mexico) focused on the acute effect of an infusion of M. tomentosa on despair-like behavior and activation of oxytocin hypothalamic cells in Wistar rats. In pre-clinical research, both the extract and some of its active metabolites have produced oxytocinergic-like effects on female reproductive organs; 18 however, there are no detailed studies of its effects on mood state and brain structures. The aim of that study 18 was to analyze the behavioral effects of acute administration of a M. tomentosa infusion on male rats, during the Open Field (OFT) and Forced Swim (FST) Tests, and their association with the activation of Oxytocin (OXT) cells, indicated by Fos protein (Fos/OXT) in the Paraventricular (PVN) and Supraoptic Nuclei (SON).…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

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<em>Montanoa tomentosa</em>. A review of the new scientific evidence on pharmacological properties

et al. 2022

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Montanoa tomentosa is a shrub, belonging to the Asteraceae family, originally from Mexico and Central America known for its medicinal properties. The origins of its use in the field of herbal medicine can be traced back to the Mexican tradition. It was used for sexual dysfunctions. The extract of leaves was used in women to induce menstruation, abortion and labor, and also to reduce postpartum bleeding. The leaves are also used for their diuretic properties and the ground roots are used in the treatment of dysentery. Over time, studies have been conducted to identify the compounds responsible for the therapeutic activity and their mechanism of action. Two studies conducted in rats demonstrated the aphrodisiac properties of Montanoa tomentosa. This activity has been attributed to the presence of components that act as oxytocic agents. Furthermore, other studies have shown that Montanoa has anxiolytic properties. The mechanism underlying this action lies in the interaction with the GABAA receptor. However, it has been shown that the anxiolytic effect is influenced by the individual endocrine status: in conditions of low hormone levels the anxiolytic effect is more pronounced; in conditions of high hormonal levels, a state like anxiety is observed. Despite the multiple properties of Montanoa, today’s research is geared towards strengthening its clinical relevance as a natural antidepressant agent.

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Section: Pharmacological Propertiesmentioning

confidence: 99%

Section: Pharmacological Propertiesmentioning

confidence: 99%

Section: Pharmacological Propertiesmentioning

confidence: 99%

Section: Pharmacological Propertiesmentioning

confidence: 99%

See 2 more Smart Citations

<em>Montanoa tomentosa</em>. A review of the new scientific evidence on pharmacological properties

et al. 2022

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“…However, it has been reported that intrauterine administration of the decoction of M. tomentosa relieves inflammation of the uterus (postpartum metritis) of dairy cows without altering the ovarian activity; this emmenagogue action was attributed to the oxytocin like properties of the extract at the corpus luteum (Ortiz et al, 2007). Besides, the oral administration of M. tomentosa decoction (50 mg/kg) activated oxytocin producing cells in hypothalamic nuclei, which may be associated with its anti-depressant like effect (Lagunes-Merino et al, 2019).…”

Section: Cihuapahtli: the Women's Medicinementioning

confidence: 99%

On the first book of medicinal plants written in the American Continent:The LibellusMedicinalibus Indorum Herbisfrom Mexico, 1552. A review

Reyes-Chilpa¹,

Guzmán-Gutiérrez²,

Campos-Lara³

et al. 2021

BLACPMA

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The "Libellus de Medicinalibus Indorum Herbis" (Little Book of Indian Medicinal Plants) was composed by the indigenous sages Martín De la Cruz and Juan Badiano, 31 years after the Aztec Empire fall. The former was the author, and the latter translated the manuscript from the Nahuatllanguage to Latin. It contains numerous recipes for treating human diseases and 185 colored drawings of the prescribed plants. In 1939 it was first published as "An Aztec Herbarium". However, it also contains XVI century European diseases and medical practices. We present an updated review of this beautiful codex, its history, conception, creators, and botany; as well as, the chemistry and pharmacology of fiveplants therein cited. The Libellusis a window in the time that allows the scientific research of ancient ethnopharmacological knowledge in Mesoamerica and document its persistence, disappearance, or transformation. However, this requires overcoming linguistic defies, but also derived from its historical, anthropological, cultural, botanical, and medical context.

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The Sensitive Plant Mimosa Pudica: Aspiration of Sexual Motivation

2023

IJBPAS

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Background: Herbal medicines are known to be the most potent aphrodisiac activity with the lowest possible side effects. Thus, it is aiming to evaluate aphrodisiac activity of extracts of roots of Mimosa pudica in male albino rats.Materials and Methods: Chloroform, alcoholic and aqueous extracts of roots of Mimosa pudica at a dose of 200 mg/kg and 400 mg/kg were administered in the male albino rats after sexual experiences for seven days.Hormonal therapy was used to make the female rats in the mating course friendly. General mating in behavior and libido were studied. Data were analyzed statistically by the method of One way ANOVA in GraphPad software and values were expressed as Mean ± standard deviation.Results: Oral administration of solvent extracts at dosages of 200 mg/kg and 400 mg/kg substantially enhanced increase in the mounting frequency, intromission frequency and ejaculation latency, while decrease in the mounting latency, intromission latency and post-ejaculatory interval. It is also improved libido to the rats. Conclusion:The alcoholic extract of roots of Mimusa pudica has the capacity to build aphrodisiac activity in male albino rats. Thus Mimusa pudica will be clinically helpful as sexual invigorator in males.

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Acute effect of an infusion of Montanoa tomentosa on despair-like behavior and activation of oxytocin hypothalamic cells in Wistar rats

Cited by 6 publications

References 32 publications

<em>Montanoa tomentosa</em>. A review of the new scientific evidence on pharmacological properties

<em>Montanoa tomentosa</em>. A review of the new scientific evidence on pharmacological properties

On the first book of medicinal plants written in the American Continent:The LibellusMedicinalibus Indorum Herbisfrom Mexico, 1552. A review

The Sensitive Plant Mimosa Pudica: Aspiration of Sexual Motivation

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