<em>Montanoa tomentosa</em>. A review of the new scientific evidence on pharmacological properties

Abstract

Montanoa tomentosa is a shrub, belonging to the Asteraceae family, originally from Mexico and Central America known for its medicinal properties. The origins of its use in the field of herbal medicine can be traced back to the Mexican tradition. It was used for sexual dysfunctions. The extract of leaves was used in women to induce menstruation, abortion and labor, and also to reduce postpartum bleeding. The leaves are also used for their diuretic properties and the ground roots are used in the treatment of dysentery. Over time, studies have been conducted to identify the compounds responsible for the therapeutic activity and their mechanism of action. Two studies conducted in rats demonstrated the aphrodisiac properties of Montanoa tomentosa. This activity has been attributed to the presence of components that act as oxytocic agents. Furthermore, other studies have shown that Montanoa has anxiolytic properties. The mechanism underlying this action lies in the interaction with the GABAA receptor. However, it has been shown that the anxiolytic effect is influenced by the individual endocrine status: in conditions of low hormone levels the anxiolytic effect is more pronounced; in conditions of high hormonal levels, a state like anxiety is observed. Despite the multiple properties of Montanoa, today’s research is geared towards strengthening its clinical relevance as a natural antidepressant agent.

Effect of Zoapatle (Montanoa tomentosa) on Inflammatory Markers in a Murine Model of Ventricular Hypertrophy

“…In addition, beneficial anxiolytic-like actions have been showed with the participation of the subunit GABA-A receptor, which was demonstrated in models to be entirely blocked by picrotoxin and bicuculine [12,13]. It has been reported that the effect of Zoapatle can modulate mood states [7,14] and also exerts a pro-ejaculatory effect acting directly on the spinal system through an oxytocin-like effect [15]. It has been shown that Zoapatle at low doses (3.0 mg/kg) generates anxiolytic-like actions, and at higher doses, sedative effects (>12 mg/kg) have been observed; the likely signaling mechanism is carried out through GABA-A receptors [16].…”