Acute Delirium due to Parenteral Tramadol

Ghosh, Soumitra; Mondal, Supriya Kumar; Bhattacharya, Aniruddha; Saddichha, Sahoo

doi:10.1155/2013/492685

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…This also explains why psychotropic drugs are also offenders in inducing delirium, as they interfere with the serum anticholinergic activity. Drugs [7,9] that are agonists or antagonists of other neurotransmitters, such as somatostatin, endorphins, serotonin, norepinephrine, and γ-aminobutyric acid can produce delirium-like effects. Other drugs, which can cross the blood–brain barrier and are concentrated in brain tissue, such as propranolol and imipenem, [10] may also increase the incidence of central nervous system (CNS) side effects including delirium.…”

Section: Discussionmentioning

confidence: 99%

Delirium induced by tigecycline treatment for Acinetobacter baumannii infection

Zheng

Jiang²,

Xue³

et al. 2019

Medicine

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Rationale: Tigecycline is a broad-spectrum antimicrobial agent structurally belong to tetracyclines and covers against many multidrug-resistant organisms. Arising clinical cases reporting its adverse drug reactions have emerged alongside with the increasing off label use globally. By literature review, delirium caused by tigecycline has not been reported yet. We present what we believe to be the first case of tigecycline-induced delirium. Patient concerns: A 77-year-old male patient with end-stage renal disease was hospitalized due to acute exacerbation of chronic obstructive pulmonary disease. Diagnosis: The patient developed delirium after infused with a loading dose of tigecycline for pulmonary infection. Interventions: All potential causes inducing delirium were evaluated and the symptoms improved soon after discontinuation of tigecycline. He experienced delirium once again after reusing tigecycline for the exacerbation of the pulmonary infection even without a loading dose. Tigecycline was discontinued and the symptoms quickly relieved. Outcomes: According to the Naranjo adverse drug reaction probability scale, tigecycline was the probable cause of his delirium. Lessons: Clinicians should be aware of this potential adverse effect of tigecycline. We recommend that clinicians monitor patients for signs and symptoms of delirium during treatment with tigecycline.

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Section: Discussionmentioning

confidence: 99%

Delirium induced by tigecycline treatment for Acinetobacter baumannii infection

Zheng

Jiang²,

Xue³

et al. 2019

Medicine

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“…99 In terms of psychotropics, delirium has been reported with discontinuation of sertraline, 100 use of olanzapine, 101 valproate associated hyperammonemia, [102][103][104] restarting of clozapine, 105 mirtazapine associated hyponatremia, 106 use of a combination of clozapine and electroconvulsive therapy (ECT), 107,108 use of a combination of lithium and ECT, 109,110 and postinjection delirium/sedation syndrome associated with olanzapine depot injection. [111][112][113][114][115] Some of the case reports/case series focus on substance-related delirium, [116][117][118][119][120][121][122][123][124][125][126][127][128] either during the withdrawal phase or intoxication phase. The case reports also cover topics like refractory delirium tremens, delayed onset delirium tremens, delirium tremens with hollow viscus perforation, genital self-mutilation in alcohol withdrawal state complicated with delirium, delirium during opioid withdrawal, 122 naltrexone precipitating delirium, 121 delirium due to use of parental tramadol, 125 varenicline-induced delirium, 126 and delirium associated with zolpidem withdrawal 127 or intoxication.…”

Section: Case Reports Focusing On Deliriummentioning

confidence: 99%

“…[111][112][113][114][115] Some of the case reports/case series focus on substance-related delirium, [116][117][118][119][120][121][122][123][124][125][126][127][128] either during the withdrawal phase or intoxication phase. The case reports also cover topics like refractory delirium tremens, 116 delayed onset delirium tremens, delirium tremens with hollow viscus perforation, 120 genital self-mutilation in alcohol withdrawal state complicated with delirium, 116 delirium during opioid withdrawal, 122 naltrexone precipitating delirium, 121 delirium due to use of parental tramadol, 125 varenicline-induced delirium, 126 and delirium associated with zolpidem withdrawal 127 or intoxication. 128 Delirium has also been reported in association with various physical illnesses such as nephrotic syndrome, 129 chronic lymphocytic leukemia, 130 Parkinson's disease, 131 pancreatic pseudocyst, 132 hypopituitarism, 133 postoperative state, 134 sepsis, 135 tuberculous meningitis, 136,137 and thalamic infarcts.…”

Section: Case Reports Focusing On Deliriummentioning

confidence: 99%

Delirium Research in India: A Systematic Review

Grover

Kathiravan

Dua

2021

JNRP

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Delirium is the most common psychiatric diagnoses encountered in patients with various medical-surgical illnesses, in all the treatment set-ups, with relatively higher incidence and prevalence in the intensive care units. As delirium is encountered in multiple specialties, it is important to understand the research on this diagnosis. This study aims to assess the research output involving patients of delirium from India. A comprehensive search was undertaken using Medline (PubMed) and other databases. Search words included were “delirium,” “delirious,” “delirium tremens” AND “India.” No filters were used. Internet and hand searches yielded 305 articles. Out of these articles, 151 had the terms “delirium,” “delirious,” “delirium tremens” in the title and these were included for the review. Additionally, 14 articles were included for the review, although these did not have these terms in the title, but delirium was one of the major outcome parameters in these studies. Majority of the papers were original articles (n = 81), and these were followed by, case reports (n = 58), review articles (n = 10), letter to the editor (not as case reports but as a communication; n = 13), editorials (n = 2) and one clinical practice guideline. Most of the original papers have either focused on epidemiology (incidence, prevalence, outcome, etc.), symptom profile, with occasional studies focusing on effectiveness of various pharmacological interventions. There is a dearth of research in the field of delirium from India. There is a lack of studies on biomarkers, evaluation of nonpharmacological interventions, and evaluation of prevention strategies. It is the need of the hour to carry out more studies to further our understanding of delirium in the Indian context.

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“…. Several other reports have described cases of acute/chronic delirium of varying severity temporally linked to tramadol administration . The drug's potent metabolite, O‐desmethyltramadol, is believed to cause delirium via an inhibition of cholinergic neurotransmission, an increase in serotonin and noradrenaline levels, and an activation of opioid receptors .…”

mentioning

confidence: 99%