Acute coronary syndrome associated with essential thrombocythemia

Kumagai, Naoya; Mitsutake, Ryoko; Miura, Shin‐ichiro; Kawamura, Akira; Takamiya, Yosuke; Nishikawa, Hiroaki; Uehara, Yoshio; Saku, Keijiro

doi:10.1016/j.jjcc.2009.03.001

Cited by 16 publications

(12 citation statements)

References 18 publications

(22 reference statements)

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“…Tefferi et al17) reported that major thrombotic complications, such as cerebral ischemic attack and acute coronary syndrome, occurred in 7% of ET patients. Cases of acute coronary syndrome with ET were reported by some authors,18-20) but our experience of VLST associated with ET was unique.…”

Section: Discussionmentioning

confidence: 79%

Very Late Stent Thrombosis in a Drug-Eluting Stent due to Interruption of Anti-Platelet Agents in Patients With Acute Myocardial Infarction and Thrombocytosis

et al. 2011

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Stent thrombosis is a fatal complication in patients who have undergone percutaneous coronary intervention, and discontinuation of anti-platelet agent is a major risk factor of stent thrombosis. We report a rare case of very late stent thrombosis (VLST) following discontinuation of anti-platelet agents in a patient who experienced acute myocardial infarction and essential thrombocytosis. She had undergone implantation of a drug eluting stent (DES) and a bare metal stent (BMS) two and half years prior to her presentation. VLST developed in DES, not in BMS, following interruption of anti-platelet therapy.

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Section: Discussionmentioning

confidence: 79%

Very Late Stent Thrombosis in a Drug-Eluting Stent due to Interruption of Anti-Platelet Agents in Patients With Acute Myocardial Infarction and Thrombocytosis

et al. 2011

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“…We found 18 cases of patients with an acute coronary syndrome and essential thrombocythemia in the literature. One third of them did not have typical changes on coronary angiography [6]. Therefore it seems important to treat thrombocythemia especially in the context of described symptoms of TTS, history of TIA and vision impairment.…”

Section: Discussionmentioning

confidence: 97%

Patient with transient left ventricular apical ballooning and essential thrombocythemia

Kaaz¹,

Przewlocka‐Kosmala²,

Gajek³

et al. 2011

pwki

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A b s t r a c tTako-tsubo syndrome imitates acute myocardial infarction. In this article, we report a case of a 39-year-old male who presented with essential thrombocythemia and symptoms and signs of acute coronary syndrome. On the basis of clinical features and results of additional tests we recognized transient left ventricular apical ballooning.Key words: tako-tsubo syndrome, male, essential thrombocythemia, transient left ventricular apical ballooning S t r e s z c z e n i eZespół tako-tsubo często imituje objawy zawału mięśnia serca. W artykule przedstawiono pacjenta z objawową nadpłytkowoś-cią oraz objawami przedmiotowymi i podmiotowymi ostrego zespołu wieńcowego. Na podstawie całokształtu obrazu chorobowego rozpoznano przemijające zaburzenia kurczliwości lewej komory.Słowa kluczowe: zespół tako-tsubo, mężczyzna, nadpłytkowość samoistna, przemijające zaburzenia kurczliwości lewej komory

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“…Both findings suggest that the anticoagulant protein C directly or indirectly influences platelet production (and possibly consumption and/or clearance), a phenomenon that, to our knowledge, has not been described before. In human studies, it has been suggested that increased platelet levels are a risk factor for atherothrombotic events, making it tempting to speculate that the higher platelet levels upon siProc-treatment contribute to the development of atherothrombosis in the aortic root 37,38 . For now, it is however not clear whether the increased platelets predict aortic root atherothrombosis susceptibility or whether they are a consequence of the event.…”

Section: Discussionmentioning

confidence: 99%

Predilection of low protein C-induced spontaneous atherothrombosis for the right coronary sinus in apolipoprotein E-deficient mice

et al. 2018

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Silencing of anticoagulant protein C using RNA interference (siProc) evokes low incident but spontaneous atherothrombosis in the aortic root of apolipoprotein E-deficient (Apoe −/−) mice. The aims of the current study were (1) to analyze if plaque characteristics or circulating factors could be linked to atherothrombosis susceptibility, (2) to increase the incidence of atherothrombosis by transiently increasing blood pressure, and (3) to direct atherothrombosis to an additional predefined vascular site by applying a semi-constrictive collar around the carotid artery. siProc-driven spontaneous atherothrombosis in the aortic root of Apoe −/− mice was reproduced and occurred at an incidence of 23% (9 out of 39 mice), while the incidence of collar-induced atherothrombosis in the carotid artery was 2.6% (1 out of 39 mice). Treatment with phenylephrine, to transiently increase blood pressure, did not increase atherothrombosis in the aortic root of the Apoe −/− mice nor in the carotid arteries with collars. Plaques in the aortic root with an associated thrombus were lower in collagen and macrophage content, and mice with atherothrombosis had significantly more circulating platelets. Plasma protein C, white blood cell counts, total cholesterol, fibrinogen, serum amyloid A, and IL-6 were not different amongst siProc treated mice with or without thrombosis. Remarkably, our data revealed that thrombus formation preferably occurred on plaques in the right coronary sinus of the aortic root. In conclusion, there is a predilection of low protein C-induced spontaneous atherothrombosis in Apoe −/− mice for the right coronary sinus, a process that is associated with an increase in platelets and plaques lower in collagen and macrophage content.

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Acute coronary syndrome associated with essential thrombocythemia

Cited by 16 publications

References 18 publications

Very Late Stent Thrombosis in a Drug-Eluting Stent due to Interruption of Anti-Platelet Agents in Patients With Acute Myocardial Infarction and Thrombocytosis

Very Late Stent Thrombosis in a Drug-Eluting Stent due to Interruption of Anti-Platelet Agents in Patients With Acute Myocardial Infarction and Thrombocytosis

Patient with transient left ventricular apical ballooning and essential thrombocythemia

Predilection of low protein C-induced spontaneous atherothrombosis for the right coronary sinus in apolipoprotein E-deficient mice

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