Acute Cor Pulmonale in Critically Ill Patients with Covid-19

Creel-Bulos, Christina; Hockstein, M.J.; Amin, Neha; Melhem, Samer; Truong, Alexander D.; Sharifpour, Milad

doi:10.1056/nejmc2010459

Cited by 123 publications

(150 citation statements)

References 5 publications

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“…Thrombolytic use has been suggested as a therapeutic option in patients with COVID-19 with acute RV dysfunction, especially because of increased incidence of elevated D-dimer and venous thromboembolism in these patients. 15 Our patient did not receive thrombolysis, because of low clot burden as noted in the imaging studies, and increased risk for bleeding complications due to severe thrombocytopenia and multiorgan dysfunction. He was also excluded from being considered for extracorporeal support because of his comorbidities and multiorgan dysfunction.…”

Section: Discussionmentioning

confidence: 89%

Acute Right Ventricular Dysfunction in a Critically Ill Patient with COVID-19

Venkata¹,

Aruchamy²,

Kasal³

2020

CASE

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Section: Discussionmentioning

confidence: 89%

Acute Right Ventricular Dysfunction in a Critically Ill Patient with COVID-19

Venkata¹,

Aruchamy²,

Kasal³

2020

CASE

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“…Teilweise zeigt sich bei schwer betroffenen Patienten auch ein akutes Cor pulmonale ohne offensichtliche Lungenembolie, was auf mikrovaskuläre Gefäßverschlüsse hinweisen könnte [9]. In Obduktionen verstorbener Patienten bestätigte sich dieser Befund und es zeigten sich häufig ausgeprägte Beinvenenthrombosen sowie Lungenembolien [7].…”

Section: Merkeunclassified

COVID-19 aus Sicht der Kardiologie

Weckbach

Kellnar

Stremmel

et al. 2020

Dtsch Med Wochenschr

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The SARS-CoV-2 pandemic has rapidly spread around the world and has led to a substantial morbidity and mortality in many countries. Although Corona Virus Disease 19 (COVID-19) is primarily a respiratory tract infection, there is growing evidence that other organs including the cardiovascular system are affected by COVID-19. In this review, we summarize the association of myocardial injury with in-hospital mortality of COVID-19 patients. Furthermore, we discuss potential mechanisms of myocardial injury including myocarditis and vascular thrombosis. Last, we review the current evidence on drugs which have been evaluated or are currently tested for the treatment of COVID-19 patients.

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“…Bleeding is not common in COVID-19. Deep vein thrombosis (DVT), venous thromboembolism, pulmonary embolism (PE) and cor pulmonale, systemic and pulmonary arterial thrombosis and embolism, ischemic stroke and myocardial infarction (MI) are reported [5][6][7][8][9][10]. DVT and PE are common among the dead [7].…”

Section: Effect On Coagulationmentioning

confidence: 99%

“…DVT and PE are common among the dead [7]. This is caused by inflammation, platelet activation, hypercoagulability, endothelial dysfunction, constriction of blood vessels, stasis, hypoxia, muscle immobilization, and disseminated intravascular coagulation (DIC) [5][6][7][8][9][10].…”

Section: Effect On Coagulationmentioning

confidence: 99%

Effect of COVID-19 on the Organs

Jain¹

2020

Cureus

131

114

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The COVID-19 pandemic that first became apparent in Wuhan, China, is now infecting millions all over the world. This is a review of COVID-19's extensive effects on virtually all the organs. It causes inflammation, endotheliitis, vasoconstriction, hypercoagulability, and edema. Lymphocytopenia, elevated D-dimer, elevated fibrin degradation products (FDPs), and disseminated intravascular coagulation (DIC) are observed. Deep vein thrombosis (DVT), venous thromboembolism, pulmonary embolism (PE), systemic and pulmonary arterial thrombosis and embolism, ischemic stroke, and myocardial infarction (MI) are reported. In the heart it can cause acute coronary syndrome, congestive heart failure, myocarditis, and arrhythmias. Kidney injury is usually secondary to systemic abnormalities. Stroke occurs even in young patients. Delirium and seizures are common. Anosmia and impaired sense of taste are reported. Psychological problems are common among patients as well as providers. Stool may contain virus. Lactate dehydrogenase may be elevated. Various skin manifestations including patchy erythematous rash are reported.

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Acute Cor Pulmonale in Critically Ill Patients with Covid-19

Cited by 123 publications

References 5 publications

Acute Right Ventricular Dysfunction in a Critically Ill Patient with COVID-19

Acute Right Ventricular Dysfunction in a Critically Ill Patient with COVID-19

COVID-19 aus Sicht der Kardiologie

Effect of COVID-19 on the Organs

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