Acute Complications of Preeclampsia

Norwitz, Errol R.; Hsu, Chaur Dong; Repke, John T.

doi:10.1097/00003081-200206000-00004

Cited by 107 publications

(74 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8 Several potential candidate biochemical markers have been proposed to predict the severity of preeclampsia. 5,9 The multi organ dysfunction in preeclampsia caused by vascular endothelial damage, including maternal liver, kidney, lungs, nervous system, coagulation system will leads to excessive LDH leakage and elevated levels in serum due to cellular dysfunction, which may cause the occurrence of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of serum lactate dehydrogenase and gamma glutamyl transferase in preeclamptic pregnancy and its comparison with normal pregnancy in third trimester

Sarkar

Sogani

2013

Int J Res Med Sci

View full text Add to dashboard Cite

INTRODUCTIONPreeclampsia is a clinical manifestation characterized by hypertension, proteinuria and edema that occurs after 20 th week of pregnancy. It is a multisystem disorder of pregnancy with potentially severe consequences for both mother and child.1 It affects about 5-8% of all pregnancies and is a major cause of maternal, fetal and neonatal mortality and morbidity. 2,3 The etiology of preeclampsia is unknown but thought to be related to hypoxia in the placenta and endothelial dysfunction. 4 The various causes that leads to these abnormalities ABSTRACT Background: Preeclampsia affects about 5-8% of all pregnancies and is a major cause of maternal, fetal and neonatal mortality and morbidity. Evidences prove that endothelial cell and altered endothelial cell function play an important role in the pathogenesis of preeclampsia. Therefore serum lactate dehydrogenase (LDH) and serum gamma glutamyl transferase (GGT) are the useful biochemical markers reflecting the severity of the occurrenc e of preeclampsia. The objective was to determine serum lactate dehydrogenase (LDH) and serum gamma glutamyl transferase (GGT) as biochemical markers in preeclamptic pregnant women and its comparison with normal pregnant women in third trimester. Methods: This is the case-control hospital based study carried in the Department of Biochemistry M.G.M. Medical College and associated M.Y. Hospital. Indore (M.P.). Normal pregnant women (n=48), women with preeclampsia (n=53) were included in the study. Both the groups were in their third trimester and of same age and same gestational age. Preeclamptic group was further divided into two subgroups mild (n=36) and severe (n=17) preeclampsia. Results: There were no significant differences among the three groups in age and body mass index but significantly higher differences in gestational age, systolic and diastolic blood pressure was observed. Higher values of serum lactate dehydrogenase (LDH) were found in mild and severe preeclamptic women than those of normal pregnant women in third trimester but the values of serum LDH was significantly elevated in severe preeclamptic women when comparison was done between mild and severe preeclamptic women. Serum GGT was significantly higher among all the groups. Conclusion: Elevated levels of serum LDH and serum GGT indicates the tissue damage related to endothelial vascular damage and are the main cause of the occurrence of preeclampsia.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of serum lactate dehydrogenase and gamma glutamyl transferase in preeclamptic pregnancy and its comparison with normal pregnancy in third trimester

Sarkar

Sogani

2013

Int J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…6,7 It carries substantial risks for both fetus and mother with a subsequent increase in the perinatal and maternal morbidity and mortality'. 1,2 For established disease with involvement of various systems, several markers have been proposed, like markers for renal and liver function -urea, creatinine, uric acid, aspartate, and alanine transaminases, vascular function (prostacyclin, thromboxane, fibronectin, homocystine, nitric acid, cytokines), coagulation and fi brinolytic systems (tissue plasminogen activators, platelets, fibrinogen, antithrombin III, Von Willebrand factor), oxidative stress and lipids (lipid peroxides, antioxidants, lipoproteins), and placental function (human chorionic gonadotropin, corticotrophin releasing hormone, placental growth factor, a-fetoprotein, inhibin, activin, and uteroplacental fl ow (velocity wave form)'. [5][6][7] Lactic dehydrogenase (LDH) is an intracellular enzyme that converts lactic acid to pyruvic acid, and elevated levels indicate cellular death and leakage of the enzyme from the cell.…”

Section: Introductionmentioning

confidence: 99%

Role of serum LDH in preeclampsia as a prognostic factor – a cross sectional case control study in tertiary care hospital

Mary

Chellatamizh

Padmanaban³

2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: LDH is an intracellular cytoplasmic enzyme. It is ubiquitous to all the major organ systems. Cellular enzymes in extracellular space have no metabolic function, although they serve as indicators of disturbances in cellular integrity. Serum LDH is abnormal in many disorders, therefore total serum LDH is highly sensitive but nonspecific test. In preeclampsia also LDH may be elevated and can indicate the prognosis for both mother and fetus. We conducted this study to examine the relationship between lactate dehydrogenase concentration and the severity of the disease and the occurrence of its complications.Methods: 200 pre-eclamptic women (121 with mild and 79 with severe pre-eclampsia) and 200 healthy normotensive controls were studied prospectively at Government Kilpauk medical college and hospital between January and December 2015. Demographic, hemodynamic, and laboratory data were compared among the three groups. The symptoms and complications of severe pre-eclampsia along with fetal outcome were analyzed according to the levels of LDH.Results: Severely pre-eclamptic patients were significantly younger, with low gravidity and parity. On the other hand, they had significantly increased systolic and diastolic pressure and liver enzymes, uric acid, urine albumin, and LDH levels. The symptoms and complications of pre-eclampsia along with perinatal mortality were increased significantly in patients with LDH >800 IU/l compared with those who had lower levels.Conclusions: Lactate dehydrogenase is a useful biochemical marker that reflects the severity of pre-eclampsia. In our study, LDH has been evaluated as a biochemical marker for preeclampsia and as a prognosticator of the disease severity. Detection of high-risk patients with increased levels of LDH mandate close monitoring and management to prevent maternal and fetal morbidity and mortality.

show abstract

“…17 The prevention of preeclampsia complication has become main task to reduce maternal and perinatal morbidity and mortality. Treating obstetricians have to be more alert to diagnose early and manage comprehensively to prevent further progression of the disease.…”

Section: Discussionmentioning

confidence: 99%