Acute Cholecystitis Following Allogeneic Hematopoietic Stem Cell Transplantation: Clinical Features, Outcomes, Risk Factors, and Prediction Model

Zhang, Zhuangyi; He, Yun; Zhu, Xiaolu; Liu, Xiao; Fu, Hai-Xia; Wang, Feng-Rong; Mo, Xiao‐Dong; Wang, Yu; Zhang, Yuanyuan; Wang, Han; Yao, Chen; Yan, Chen‐Hua; Wang, Jing‐Zhi; Chen, Yuhong; Chang, Ying‐Jun; Xu, Lei; Liu, Kai-Yan; Huang, Xiao‐Jun; Zhang, Xiaohui

doi:10.1016/j.jtct.2020.12.016

Cited by 1 publication

(2 citation statements)

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“…(2) The patients met the diagnosis criteria for AAC [12] (3) The patients were clearly diagnosed with normal gallbladder on admission and then were diagnosed with AAC during ICU treatment (4) The patients were at least 18 years old (5) The patients did not have severe cirrhosis, liver failure, acute leukemia, and other diseases (6) The patients were confirmed to have no cholecystolithiasis and choledocholith after imaging examination (7) The patients did not have the history of cholecystectomy (8) The patients had complete clinical data (9) The patients and their family members understood the study and signed the informed consent Finally, 47 AAC patients who were treated in our hospital from March 2016 to March 2022 and met the study criteria were selected as the AAC group.…”

Section: Selection Of Study Subjects In the Aac Groupmentioning

confidence: 99%

“…Acute acalculous cholecystitis (AAC) is a clinical emergency with lower morbidity, which tends to occur in critically ill patients with severe trauma, burns, shock, hypotension, or after major surgery, is featured with insidious onset, atypical clinical presentation, and rapid progression of the condition, and easily causes perforated gangrene and other complica-tions, leading to a high clinical mortality [1][2][3][4]. Most patients treated in ICU inpatient areas are critically ill with complex condition and often accompanied by multivisceral dysfunction, so they are at high risk for AAC; in addition, patients who undergo the therapeutic means such as sedation and mechanical ventilation often have disorders of consciousness, and thus, the condition of AAC is not easily perceived, resulting in a prolonged disease course and a high clinical mortality rate of 45-50% [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Correlation of Inpatients Suffering from Acute Acalculous Cholecystitis during ICU Treatment with Acute Physiology and Chronic Health Evaluation II Score, Duration of Ventilator Use, and Time on Total Parenteral Nutrition

Zhang

Wang

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the correlation of inpatients suffering from acute acalculous cholecystitis (AAC) during ICU treatment with Acute Physiology and Chronic Health Evaluation II (APACHE-II) score, duration of ventilator use, and time on total parenteral nutrition (TPN). Methods. From March 2016 to March 2022, the clinical data of 47 patients with AAC who received ICU treatment in our hospital were retrospectively reviewed, and these patients were included in the AAC group. Another 36 patients treated in the ICU in the same period with age and gender matching with those in the AAC group were selected as the non-AAC group. Patients’ various clinical data were recorded to analyze the correlation of AAC with APACHE-II score, duration of ventilator use, and time on TPN. Results. The shock time, duration of ventilator usage, and duration of sedative medicine use were all substantially longer in the AAC group than in the non-AAC group, according to the univariate analysis ( P < 0.05 ); the amount of norepinephrine used, white blood cell count, C-reactive protein (CRP) amount, and APACHE-II score were significantly higher in the AAC group than in the non-AAC group ( P < 0.05 ); between the two groups, the time on TPN and fasting time were different, but with no statistical significance ( P > 0.05 ); after performing Spearman’s correlation with the significantly between-group different indicators, the result showed that the amount of norepinephrine used, duration of ventilator use, white blood cell count, and CRP amount were significantly correlated with the occurrence of AAC, and the correlation was positive ( P all <0.001). Conclusion. The APACHE-II score and time on TPN are not significantly correlated with the occurrence of AAC; and the amount of norepinephrine used, duration of ventilator use, white blood cell count, and serum CRP are positively correlated with the occurrence of AAC. Measuring the variations in the levels of various markers can signal the onset of AAC or reflect the state and prognosis, suggesting a possible application in clinic-based targeted prevention and treatment of AAC.

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