Acute changes in lung mechanics following pulmonary emboli of various gases in dogs.

Khan, Maqsood Ahmed; Alkalay, I; Suetsugu, Saiko; Stein, Martin H.

doi:10.1152/jappl.1972.33.6.774

Cited by 39 publications

(15 citation statements)

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“…Thus induction of intravascular platelet aggregation with platelet antiserum, ADP and collagen (Vaage, B0 & Hognestad, 1974), protamine chloride (Radegran & McAslan, 1972), air emboli (Khan, Alkalay, Suetsugu & Stein, 1972) and bacterial endotoxin (Stein & Thomas, 1967) affected lung mechanics in a similar manner to pulmonary microembolization. These effects could be prevented by prior induction of thrombocytopaenia (platelet counts less than 50000/,ul) with platelet antiserum (Khan et al 1972) or endotoxin (Stein & Thomas, 1967). Moreover, injection of autologous thromboemboli into dogs (Cade, 1975), barium sulphate into cats (B0 et al 1974) and glass beads into dogs (Mlczoch, Tucker, Weir, Reeves & Grover, 1978) produced significantly smaller increases in pulmonary arterial pressures in thrombocytopaenic animals than in normal animals.…”

Section: Discussionmentioning

confidence: 99%

The role of platelets in the reflex tachypnoeic response to miliary pulmonary embolism in anaesthetized rabbits

Armstrong

Sa²

1990

Experimental Physiology

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SUMMARYExperiments were performed upon twenty-eight male Californian rabbits anaesthetized with sodium pentobarbitone and breathing room air. Successive injections of glass bead emboli (diameter 125,am) caused an increase in respiratory rate, and decreases in tidal volume (tachypnoeic response) and platelet count. The tachypnoeic response was not observed in rabbits that had been rendered thrombocytopaenic by platelet antiserum. Induction of thrombocytopaenia by antiserum was accompanied by tachypnoea which was not significantly different (P > 0 05) from the response to emboli. The tachypnoeic response to antiserum, like that to emboli, was prevented by bilateral cervical vagotomy. Pre-treatment with aspirin (5 mg/kg), which inhibits the platelet-release reaction, also prevented the tachypnoeic response to both emboli and antiserum, although it did not prevent the fall in platelet count which followed injection of antiserum. These data support the hypothesis that the post-embolic reflex tachypnoea is platelet dependent and may be secondary to the platelet-release reaction.

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Section: Discussionmentioning

confidence: 99%

The role of platelets in the reflex tachypnoeic response to miliary pulmonary embolism in anaesthetized rabbits

Armstrong

Sa²

1990

Experimental Physiology

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“…A study on dogs found that air, nitrogen, and oxygen emboli resulted in bronchoconstriction whereas CO 2 and helium emboli did not [38]. Helium is considered safer than air, O 2 or N 2 because of its impressive diffusion capability.…”

Section: Venous Gas Embolimentioning

confidence: 99%

Laparoscopyrid=""

2000

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“…Hypotension and physiologic shunting leads to hypoxemia. In the study by Khan et al [15], dynamic pulmonary com- pliance and total lung airflow resistance remained unchanged with a 30-ml bolus injection of pure CO 2 in dogs. Therefore, bronchoconstriction alone cannot account for the observed hypoxemia.…”

Section: Physiology Of Venous Carbon Dioxide Embolismmentioning

confidence: 90%