Acute Cerebellitis in MIS-C

Abstract

Background: Coronavirus disease-2019 (COVID-19) is characterized predominantly by respiratory symptoms and has affected a small subset of children. Multisystem inflammatory syndrome in children (MIS-C) has been reported in children following COVID-19. There is increasing report that COVID-19 may also lead to neurologic manifestations. Cerebellar lesions may be observed in viral infections. Case report: We report a child with MIS-C related to severe acute respiratory syndrome coronavirus 2, who developed cerebellar lesion during the disease course. Encephalopathy was the first central nervous system symptom. His consciousness improved but he developed clinical signs of cerebellar dysfunction including ataxia, dysarthria and nystagmus. Brain magnetic resonance imaging (MRI) revealed symmetrical pathological signal changes in both cerebellar hemispheres. Conclusion: We demonstrated the first child with MIS-C to develop cerebellar lesion on brain MRI, suggestive of cerebellitis.

Bilateral lentiform and caudate nucleus lesions in a child with COVID-19: A case report

“…Neurological and radiological findings related to COVID-19 continue to be reported. One of the most recently reported radiological findings is a case of cerebellitis associated with MIS-C [ 5 ].…”

“…The patients with neurologic manifestation were treated with corticosteroids, IVIG, and therapeutic plasma exchange. Further research has had variable outcomes [ [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] ]. Besides, we treated with IVIG, our patient was discharged from the hospital with normal mental status and without weakness of all muscles.…”

“…There has been an increase in central and peripheral nervous system involvement reports in COVID-19. These neurological complications have included encephalopathy, meningoencephalitis, ischaemic stroke, cerebral venous thrombosis, seizures, acute necrotizing encephalopathy, Guillain-Barré syndrome (GBS), cerebellitis, reversible splenial lesion, microhemorrhages, and posterior reversible encephalopathy syndrome [ [2] , [3] , [4] , [5] , [6] , [7] ]. We present a 3-year-old patient with COVID-19 who presented mental status changes and acute muscular weakness, who has pathological findings on electroencephalogram (EEG) and magnetic resonance imaging (MRI).…”

Acute Cerebellitis: A Rare Complication of Multisystem Inflammatory Syndrome in Children (MIS-C)

“…Neuroinflammation could be a possible reason for neurological manifestations in MIS-C. Acute cerebellitis or acute cerebellar ataxia is seldom reported in association with MIS-C [ 4 ].…”

Intensification of an Essential Tremor by SARS-CoV-2

“…Missing is the information whether the two MRIs were carried out with or without application of contrast medium. Application of contrast medium is crucial to assess if there was brainstem encephalitis [ 2 ], rhombencephalitis [ 3 ], limbic encephalitis [ 4 ], or cerebellitis [ 5 ], as all these conditions have been previously reported as complications of SARS-CoV-2 infections.…”