Acute cerebellar ataxia due to Epstein–Barr virus

McCarthy, Claire; McColgan, Peter; Martin, Peter

doi:10.1136/practneurol-2011-000115

Cited by 9 publications

(13 citation statements)

References 6 publications

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“…Negative CSF EBV PCRs have been reported in a similar cases and this may reflect the non-infectious aetiology of the disease 1. The literature suggests the prognosis is generally good, with the majority making a full recovery.…”

Section: Discussionmentioning

confidence: 82%

“…EBV infection is estimated to manifest neurological sequallae in 2–5% of infected patients 1. Of these associations, in adults, ACA is particularly uncommon.…”

Section: Discussionmentioning

confidence: 99%

“…Epstein-Barr virus (EBV) infection is associated with neurological sequellae, but rarely there is acute cerebellar ataxia (ACA) in an adult 1. We present the case of a 26-year-old man who presented with ACA.…”

Section: Introductionmentioning

confidence: 99%

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Barr humbug: acute cerebellar ataxia due to Epstein-Barr virus

Davies¹,

Machin²,

Lavin

et al. 2016

BMJ Case Reports

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Epstein-Barr virus (EBV) infection is associated with neurological sequellae, but rarely there is acute cerebellar ataxia (ACA) in an adult. We present a novel case of a 26-year-old man, who presented with ACA. He had normal MRI and CSF analysis. Serum testing confirmed active EBV. A course of oral prednisolone 1 mg/kg for 4 weeks, with a subsequent taper was started. He made a full recovery within 3 weeks of presentation.

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Section: Discussionmentioning

confidence: 82%

“…EBV infection is estimated to manifest neurological sequallae in 2–5% of infected patients 1. Of these associations, in adults, ACA is particularly uncommon.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Barr humbug: acute cerebellar ataxia due to Epstein-Barr virus

Davies¹,

Machin²,

Lavin

et al. 2016

BMJ Case Reports

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“…To date, ataxia secondary to either mononucleosis or postinfection syndrome has been largely identified in pediatric case reports [1, 2, 4, 5]. It is a rare symptomatology in young adults, especially in the context of a clinical picture including symptoms of an acute, likely primary, viral encephalitis [3, 7].…”

Section: Discussionmentioning

confidence: 99%

“…However, serious neurological manifestations including seizures, ataxia, meningitis, encephalitis, transverse myelitis, Guillain-Barre syndrome, autonomic dysfunction, anxiety, and depression can occur in about 1% of cases [1–3]. These have been documented predominantly in the pediatric literature as part of a postviral syndrome [1, 2, 4, 5]. The patient in this case was older than the usual cohort and presented with early neurological complications including ataxia with later exacerbation of vertigo, difficulty in concentrating, noise sensitivity, and mental fatigue from minor tasks likely due to encephalitis with clinical presentation similar to postconcussion syndrome [3, 6].…”

Section: Introductionmentioning

confidence: 99%

Ataxia and Encephalitis in a Young Adult with EBV Mononucleosis: A Case Report

Hussain

Hussain²

2013

Case Reports in Neurological Medicine

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Neurological manifestations of mononucleosis are extremely rare, occurring in about 1% of all cases. However, when they occur, appropriate treatment must be undertaken to ensure appropriate symptomatic management and reduce morbidity. We present the case of a 25-year-old graduate student with weeklong complaints of fever, sore throat, fatigue, nausea, and “dizziness.” She later developed increased sleep requirements, ataxia, vertigo, and nystagmus with a positive EBV IgM titer confirming acute infectious mononucleosis. The patient was clinically diagnosed with EBV-associated cerebellitis and encephalitis, displaying neurological and psychiatric impairment commonly seen in postconcussion syndrome. MRI showed no acute changes. She was started on valacyclovir and a prednisone taper, recovering by the end of twelve weeks. Though corticosteroids and acyclovir are not recommended therapy in patients presenting with EBV-associated ataxia, clinicians may want to keep a low threshold to start these medications in case more serious neurological sequelae develop.

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Epstein‐Barr virus infection manifested by hepatitis, infectious mononucleosis, and acute cerebellar ataxia: A case report and literature review

Chou

Hsieh

Chang

2021

Adv in Digestive Medicine

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We described the case of an adult who presented with acute cerebellar ataxia (ACA) after Epstein‐Barr virus (EBV) infection. We also reviewed the literature on the pathogenesis of ACA due to EBV infection using the Pubmed database. A 25‐year‐old man suffered from fever, sore throat, and poor appetite. Ataxia with nausea and vomiting developed in the following disease course. Laboratory tests showed atypical leukocytosis and hepatitis. The serological test confirmed a recent EBV infection. Analysis of cerebrospinal fluid (CSF) was unremarkable, so was brain magnetic resonance imaging (MRI). He was diagnosed with infectious mononucleosis and ACA. He fully recovered after conservative treatment. Possible pathogenetic mechanisms of EBV‐associated central nervous system (CNS) manifestations could be categorized as a direct viral invasion of tissue and a postinfectious immune response. Most patients with ACA after EBV infection could be managed with supportive care. The diagnosis of ACA after EBV infection is typically made based on clinical symptoms and signs along with serological detection of EBV‐specific antibodies.

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Acute cerebellar ataxia due to Epstein–Barr virus

Cited by 9 publications

References 6 publications

Barr humbug: acute cerebellar ataxia due to Epstein-Barr virus

Barr humbug: acute cerebellar ataxia due to Epstein-Barr virus

Ataxia and Encephalitis in a Young Adult with EBV Mononucleosis: A Case Report

Epstein‐Barr virus infection manifested by hepatitis, infectious mononucleosis, and acute cerebellar ataxia: A case report and literature review

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