Acute cellular rejection in liver transplantation recipients following vaccination against coronavirus disease 2019: A case series

Sarwar, Raiya; Adeyi, Oyedele; Lake, John R.; Lim, Nicholas

doi:10.1002/lt.26446

Cited by 7 publications

(18 citation statements)

References 6 publications

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“…Cells in the anterior chamber There were 42 case reports [5][6][7][8][11][12][13]17,18,[20][21][22][24][25][26][27][29][30][31][32][33][34][35][37][38][39][40][41][42][43][44][45][48][49][50][51][52][53][54][55][56][57], 8 case series [9,10,14,28,36,46,47,58] and 2 cohort studies [19,23]. These studies were conducted in t...…”

Section: Study Characteristics and Qualitymentioning

confidence: 99%

“…There were reports of fifty-six organ rejection cases following COVID-19 vaccination (fifty-one new-onset cases [5][6][7][8][9][39][40][41][42][43] and five relapsed cases [5,9,36,38]) (see Table 1). Allograft rejections after COVID-19 vaccination occurred for cornea (n = 38, 67.8%) [5,8,17,[20][21][22][23][24][28][29][30][31][32][33][34][35]37,38,42,43], liver (n = 11, 19.6%) [9,25,36,39,41], kidney (n = 6, 10.7%) [6,7,18,19,26,40] and pancreas (n = 1, 1.8%) [27] transplant recipients.…”

Section: Meta-analysis Of Organs Rejection Following Covid-19 Vaccina...mentioning

confidence: 99%

“…The most common clinical presentations in these transplant patients who presented with organ rejection post-COVID-19 vaccination were diminished vision (n = 22) [5,8,17,20,[22][23][24]31,[33][34][35]37], eye redness (n = 15) [21][22][23]29,30,32,34,38,42], blurred vision (n = 14) [5,[28][29][30]32,38,42,43], ocular pain (n = 14) [8,17,22,23,29,32,34,38,43], photophobia (n = 6) [17,32,37,38,43], weakness (n = 5) [25,27,34,40], myalgia (n = 3) [29,32,…”

Section: Meta-analysis Of Organs Rejection Following Covid-19 Vaccina...mentioning

confidence: 99%

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Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis

et al. 2022

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Background: Solid organ rejection post-SARS-CoV-2 vaccination or COVID-19 infection is extremely rare but can occur. T-cell recognition of antigen is the primary and central event that leads to the cascade of events that result in rejection of a transplanted organ. Objectives: To describe the results of a systematic review for solid organ rejections following SARS-CoV-2 vaccination or COVID-19 infection. Methods: For this systematic review and meta-analysis, we searched Proquest, Medline, Embase, Pubmed, CINAHL, Wiley online library, Scopus and Nature through the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines for studies on the incidence of solid organ rejection post-SARS-CoV-2 vaccination or COVID-19 infection, published from 1 December 2019 to 31 May 2022, with English language restriction. Results: One hundred thirty-six cases from fifty-two articles were included in the qualitative synthesis of this systematic review (56 solid organs rejected post-SARS-CoV-2 vaccination and 40 solid organs rejected following COVID-19 infection). Cornea rejection (44 cases) was the most frequent organ observed post-SARS-CoV-2 vaccination and following COVID-19 infection, followed by kidney rejection (36 cases), liver rejection (12 cases), lung rejection (2 cases), heart rejection (1 case) and pancreas rejection (1 case). The median or mean patient age ranged from 23 to 94 years across the studies. The majority of the patients were male (n = 51, 53.1%) and were of White (Caucasian) (n = 51, 53.7%) and Hispanic (n = 15, 15.8%) ethnicity. A total of fifty-six solid organ rejections were reported post-SARS-CoV-2 vaccination [Pfizer-BioNTech (n = 31), Moderna (n = 14), Oxford Uni-AstraZeneca (n = 10) and Sinovac-CoronaVac (n = 1)]. The median time from SARS-CoV-2 vaccination to organ rejection was 13.5 h (IQR, 3.2–17.2), while the median time from COVID-19 infection to organ rejection was 14 h (IQR, 5–21). Most patients were easily treated without any serious complications, recovered and did not require long-term allograft rejection therapy [graft success (n = 70, 85.4%), graft failure (n = 12, 14.6%), survived (n = 90, 95.7%) and died (n = 4, 4.3%)]. Conclusion: The reported evidence of solid organ rejections post-SARS-CoV-2 vaccination or COIVD-19 infection should not discourage vaccination against this worldwide pandemic. The number of reported cases is relatively small in relation to the hundreds of millions of vaccinations that have occurred, and the protective benefits offered by SARS-CoV-2 vaccination far outweigh the risks.

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Section: Study Characteristics and Qualitymentioning

confidence: 99%

Section: Meta-analysis Of Organs Rejection Following Covid-19 Vaccina...mentioning

confidence: 99%

Section: Meta-analysis Of Organs Rejection Following Covid-19 Vaccina...mentioning

confidence: 99%

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Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis

et al. 2022

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“…The mechanisms by which immunosuppression might alter lymphocyte function in this population remains unclear. An additional wrinkle in the plot is the risk of inducing an acute rejection episode due to the heterogeneity of the immune response and possible cross reactivity ( 78 , 79 ).…”

Section: Sars Cov-2 Mrna Vaccinationmentioning

confidence: 99%

Balancing B cell responses to the allograft: implications for vaccination

et al. 2022

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Balancing enough immunosuppression to prevent allograft rejection and yet maintaining an intact immune system to respond to vaccinations, eliminate invading pathogens or cancer cells is an ongoing challenge to transplant physicians. Antibody mediated allograft rejection remains problematic in kidney transplantation and is the most common cause of graft loss despite current immunosuppressive therapies. The goal of immunosuppressive therapies is to prevent graft rejection; however, they prevent optimal vaccine responses as well. At the center of acute and chronic antibody mediated rejection and vaccine responses is the B lymphocyte. This review will highlight the role of B cells in alloimmune responses including the dependency on T cells for antibody production. We will discuss the need to improve vaccination rates in transplant recipients and present data on B cell populations and SARS-CoV-2 vaccine response rates in pediatric kidney transplant recipients.

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“…We would like to share ideas on the publication “Acute cellular rejection (ACR) in liver transplantation (LT) recipients following vaccination against coronavirus disease 2019: A case series.” [ 1 ] Sarwar et al [ 1 ] noted that “we report a series of LT recipients who developed ACR following their COVID‐19 vaccinations. Our findings highlight the need for comprehensive postvaccination surveillance programs in patients where the high immunogenicity of the vaccines could potentially provoke adverse events.…”

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confidence: 99%

Acute cellular rejection in liver transplantation recipients following coronavirus disease 2019 vaccination

Mungmunpuntipantip¹,

Wiwanitkit

2022

Liver Transplantation

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Acute cellular rejection in liver transplantation recipients following vaccination against coronavirus disease 2019: A case series

Abstract: ‐

Cited by 7 publications

References 6 publications

Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis

Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis

Balancing B cell responses to the allograft: implications for vaccination

Acute cellular rejection in liver transplantation recipients following coronavirus disease 2019 vaccination

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