Acute cardiovascular effects of methyl methacrylate monomer: Characterization and modification by cholinergic blockade, adrenergic stimulation and calcium chloride infusion

Waters, I. W.; Baran, Kathleen P.; Schlosser, Michael; Mack, James E.; Davis, William S.

doi:10.1016/0306-3623(92)90118-4

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…From a clinical standpoint, intravenous CaC1, may be of value as an adjunct to treat severe methylmethacrylate-induced hypotension; hypotension in an animal model was reversible with CaC& (16). Methylmethacrylate appears to inhibit calcium mobilization and excitation/contraction coupling both in vascular smooth muscle (this study) and in myocardium (1 9).…”

Section: Discussionmentioning

confidence: 85%

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Methylmethacrylate monomer produces direct relaxation of vascular smooth muscle in vitro

Karlsson

Wendling

Chen

et al. 1995

Acta Anaesthesiol Scand

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Methylmethacrylate bone cement is associated with severe hypotensive reactions during surgery and anesthesia. The purpose of this in vitro study was to determine if methylmethacrylate monomer could produce hypotension by acting directly on vascular smooth muscle. Segments of human saphenous vein or rabbit thoracic aorta were cut into rings. The rings were mounted in isolated tissue chambers in order to measure isometric tension development. Methylmethacrylate monomer (methylmethacrylic acid ester) produced direct relaxation of venous or aortic rings preconstricted with either potassium ion or noradrenaline. The relaxation was concentration-dependent, occurring at concentrations from 10(-3) to 10(-1) M. The relaxation of rabbit aortic rings (preconstricted with noradrenaline) was unaffected by pre-treatment with atropine, propranolol, cimetidine, indomethacin, or methylene blue. Endothelial stripping with Triton X-100, sufficient to completely abolish acetylcholine-induced relaxation, also had little effect on methylmethacrylate-induced relaxation. Methylmethacrylate produced direct relaxation of rabbit aortic rings constricted with either potassium or noradrenaline in calcium-deficient media, and inhibited subsequent calcium-induced constriction. These results suggest that methylmethacrylate monomer may interfere with intracellular and extracellular calcium mobilization and excitation/contraction coupling in vascular smooth muscle. The direct relaxation of venous and arterial smooth muscle produced by methylmethacrylate monomer may contribute in part to the hypotension that can occur when acrylic bone cement is employed during orthopedic procedures.

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Section: Discussionmentioning

confidence: 85%

“…Methylmethacrylate monomer causes hypotension in experimental animals when injected intravenously (1 1, 12, 14,16) and decreases systemic vascular resistance in some animal models (1 2, 14) and in humans (1 7) undergoing hip arthroplasty.…”

mentioning

confidence: 99%

Methylmethacrylate monomer produces direct relaxation of vascular smooth muscle in vitro

Karlsson

Wendling

Chen

et al. 1995

Acta Anaesthesiol Scand

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“…As noted above, apart from this investigation, there are no reports of other studies assessing the effects of individual dental resins on vascular reactivity under in vitro conditions. Nevertheless, several in vivo studies performed on humans and animals have demonstrated a hypotensive effect for MMA 9–12. On the other hand, other reports published recently have documented contractile effects of single‐bottle dentin primer/adhesive systems on rat carotid arteries 13, 14.…”

Section: Discussionmentioning

confidence: 99%

“…Along this line, Karlsson et al8 reported that MMA causes relaxation of human saphenous veins and rabbit aortic smooth muscle. Other investigators found that infusion of MMA in anesthetized dogs induces sustained hypotention 9, 10. MMA was also observed to produce profound hypotension in human patients after insertion of cement containing the resin into bone cavities during orthopedic surgery 11, 12.…”

Section: Introductionmentioning

confidence: 99%

Effects of dental resin components on vascular reactivity

Maddux

Abebe

Schuster

et al. 2002

J. Biomed. Mater. Res.

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The frequent use of resins in dentistry has raised the question of their compatibility with oral tissues. The present study was undertaken to determine the effects of the resin components methyl methacrylate (MMA), hydroxyethyl methacrylate (HEMA), and triethylene glycol dimethacrylate (TEGDMA) on the reactivity of blood vessels using the isolated rat aorta as a tissue model. MMA, HEMA, and TEGDMA caused endothelium-dependent and -independent relaxation of rat aortic rings in a concentration-related manner. The endothelium-dependent responses of the tissues to all the resins were significantly attenuated by N-nitro-L-arginine methyl ester (L-NAME), indicating the involvement of nitric oxide. The vasorelaxant effects of both MMA and TEGDMA on the intact and denuded aortae were markedly inhibited by indomethacin, providing evidence for the role of prostanoids in these responses. Glybenclamide selectively attenuated TEGDMA-induced relaxation of the tissues with and without endothelium to a similar extent, suggesting the activation of vascular smooth muscle K(ATP) channels by this resin. It is concluded that MMA, HEMA, and TEGDMA interfere with the function of blood vessels by inducing vasorelaxation via different mechanisms, which, depending upon the type of resin, may at least involve the release of nitric oxide and prostanoid(s), and the activation of smooth muscle K(ATP) channels. These phenomena may play a role in tissue homeostasis and certain pathophysiological conditions associated with the application of resin materials to the oral environment.

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Patient Evaluation and Selection

Stallmeyer

Zoarski

Percutaneous Vertebroplasty and Kyphoplasty

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Acute cardiovascular effects of methyl methacrylate monomer: Characterization and modification by cholinergic blockade, adrenergic stimulation and calcium chloride infusion

Cited by 8 publications

References 19 publications

Methylmethacrylate monomer produces direct relaxation of vascular smooth muscle in vitro

Methylmethacrylate monomer produces direct relaxation of vascular smooth muscle in vitro

Effects of dental resin components on vascular reactivity

Patient Evaluation and Selection

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