Methylmethacrylate monomer produces direct relaxation of vascular smooth muscle <i>in vitro</i>

Karlsson, Jan; Wendling, Woodrow W.; Chen, D.; Zelinsky, J.; Jeevanandam, Valluvan; Hellman, S; Carlsson, Christer

doi:10.1111/j.1399-6576.1995.tb04148.x

Cited by 49 publications

(26 citation statements)

References 23 publications

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“…It has been reported that methyl methacrylate (MMA) may be teratogenic and can cause adverse cardiovascular effects in animals (Phillips et al, 1971, Singh et al, 1972Karlsson et al, 1995). In addition, subcutaneous polymethyl-methacrlylate implants induced malignant tumors in rodents (Oppenheimer et al, 1955).…”

Section: (G) Pulp Studies In Animals and Humansmentioning

confidence: 99%

Biocompatibility of Resin-Modified Filling Materials

Geurtsen

2000

Critical Reviews in Oral Biology & Medicine

357

258

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Increasing numbers of resin-based dental restorations have been placed over the past decade. During this same period, the public interest in the local and especially systemic adverse effects caused by dental materials has increased significantly It has been found that each resin-based material releases several components into the oral environment. In particular, the comonomer, triethyleneglycol di-methacrylate (TEGDMA), and the 'hydrophilic' monomer, 2-hydroxy-ethyl-methacrylate (HEMA), are leached out from various composite resins and 'adhesive' materials (e.g., resin-modified glass-ionomer cements IGICsl and dentin adhesives) in considerable amounts during the first 24 hours after polymerization. Numerous unbound resin components may leach into saliva during the initial phase after polymerization, and later, due to degradation or erosion of the resinous restoration. Those substances may be systemically distributed and could potentially cause adverse systemic effects in patients. In addition, absorption of organic substances from unpolymerized material, through unprotected skin, due to manual contact may pose a special risk for dental personnel. This is borne out by the increasing numbers of dental nurses, technicians, and aentists who present with allergic reactions to one or more resin components, like HEMA, glutaraldehyde, ethyleneglycol di-methacrylate (EGDMA), and dibenzoyl peroxide (DPO). However, it must be emphasized that, except for conventional composite resins, data reported on the release of substances from resin-based materials are scarce. There is very little reliable information with respect to the biological interactions between resin components and various tissues. Those interactions may be either protective, like absorption to dentin, or detrimental, e.g., inflammatory reactions of soft tissues. Microbial effects have also been observed which may contribute indirectly to caries and irritation of the pulp. Therefore, it is critical, both for our patients and for the profession, that the biological effects of resin-based filling materials be clarified in the near future,

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Section: (G) Pulp Studies In Animals and Humansmentioning

confidence: 99%

Biocompatibility of Resin-Modified Filling Materials

Geurtsen

2000

Critical Reviews in Oral Biology & Medicine

357

258

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“…[1][2][3] The aetiology of these cardiovascular changes is unknown. Fat and marrow embolism, 4-6 the peripheral vasodilatation effect of the cement monomer, 7,8 and activation of the clotting cascade in the lungs 9 may all play a role.…”

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confidence: 99%

Cardiac output during hemiarthroplasty of the hip

Clark

Ahmed

Baxendale

et al. 2001

The Journal of Bone and Joint Surgery. British volume

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In a prospective, controlled study, we measured the effect on cardiac output of the introduction of methylmethacrylate during hemiarthroplasty for displaced fractures of the femoral neck. We treated 20 elderly patients who were similar in age, height, weight and preoperative left ventricular function with either cemented or uncemented hemiarthroplasty. Using a transoesophageal Doppler probe, we measured cardiac output before incision and at six stages of the procedure: during the surgical approach, reaming and lavage of the femoral canal, the introduction of cement, the insertion of the prosthesis, and in reduction and closure. We found that before the cement was introduced, there was no difference in stroke volume or cardiac output (p > 0.25). Cementation produced a transient but significant reduction in cardiac output of 33% (p < 0.01) and a reduction in stroke volume of 44% (p < 0.02). The introduction of cement did not affect the heart rate or mean arterial pressure. There was no significant difference in cardiac function on insertion of the prosthesis. Standard non-invasive haemodynamic monitoring did not detect the cardiovascular changes which may account for the sudden deaths that sometimes occur during cemented hemiarthroplasty. The fall in stroke volume and cardiac output may be caused by embolism occurring during cementation, but there was no similar fall during reaming or insertion of the prosthesis.

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“…Previously Karlsson et al (17) demonstrated that MMA monomer produces direct relaxation via calcium mobilization in human saphenous vein and rabbit thoracic aorta. Similarly, the calcium antagonistic effect of MMA has been demonstrated in isolated rat uterus (18).…”

Section: Discussionmentioning

confidence: 98%