Acute benzodiazepine administration induces changes in homocysteine metabolism in young healthy volunteers

Pompéia, Sabine; Grego, Bruno H.C.; Pradella-Hallinan, Márcia; Hachul, Helena; Tufik, Sérgio; D’Almeida, Vânia

doi:10.1016/j.pnpbp.2009.04.017

Cited by 3 publications

(2 citation statements)

References 54 publications

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“…Moreover, the results are in agreement with the flunitrazepam capacity to decrease cortisol levels in stressful pre‐operative situations (Irjala et al. 1987), and after acute administration in young healthy volunteers (Pompéia et al. 2009).…”

Section: Discussionsupporting

confidence: 83%

CLINICAL STUDY: FULL ARTICLE: Immunomodulating properties of gamma‐hydroxybutyrate (GHB), flunitrazepam and ethanol in ‘club drugs’ users

et al. 2010

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Despite the increasing concern about gamma-hydroxybutyrate (GHB) toxicity in users, no studies have addressed GHB and other club drugs effects on the immune system under controlled administration. Lymphocyte subsets and functional responsiveness of lymphocytes to mitogenic stimulation were measured in 10 healthy male recreational users of GHB who participated in five experimental sessions within the framework of a clinical trial. The study was randomized, double blind, double dummy and cross-over. Drug conditions were: a single oral dose of GHB (40 mg/kg or 60 mg/kg), ethanol (0.7 g/kg), flunitrazepam (1.25 mg) and placebo. Acute GHB produced a time-dependent immune impairment in the first 4 hours after drug administration associated with an increase in cortisol secretion. Although total leukocyte count remained unchanged, there was a significant decrease in the CD4 T/CD8 T-cell ratio, as well as in the percentage of mature T lymphocytes, probably because of a decrease in both the percentage and absolute number of T helper cells. A significant decrease was also observed in natural killer cells and in functional responsiveness of lymphocytes to mitogenic stimulation. Flunitrazepam administration did not produce any change in the immune system, while ethanol intake produced a decrease in B lymphocytes and in lymphocyte proliferative response to mitogens. These results provide the first evidence that GHB intake under a controlled environmental setting impairs the immunological status and confirms the alterations in the immune function caused by ethanol.

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Section: Discussionsupporting

confidence: 83%

CLINICAL STUDY: FULL ARTICLE: Immunomodulating properties of gamma‐hydroxybutyrate (GHB), flunitrazepam and ethanol in ‘club drugs’ users

et al. 2010

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“…In addition to the mechanisms well discussed by Kahn and colleagues 1 by which benzodiazepines have positive action in alcohol withdrawal, these drugs may be effective in part due to their capacity to reduce homocysteine, 15 elevated levels of which are considered a risk factor for the occurrence of alcohol withdrawal seizures. 16,17 If this reduction is confirmed after repeated dosing in actively drinking patients, it should be considered that benzodiazepines may be especially efficacious in treating those with hyperhomocysteinemia.…”

Section: To the Editormentioning

confidence: 99%

Could Lorazepam be More Effective in Alcohol Withdrawal than Other Benzodiazepines?

Pompéia¹,

D’Almeida²,

Tufik³

2011

CNS Spectr.

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Alterations of Homocysteine Serum Levels during Alcohol Withdrawal Are Influenced by Folate and Riboflavin: Results from the German Investigation on Neurobiology in Alcoholism (GINA)

Heese

Linnebank

Semmler

et al. 2012

Alcohol and Alcoholism

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Acute benzodiazepine administration induces changes in homocysteine metabolism in young healthy volunteers

Cited by 3 publications

References 54 publications

CLINICAL STUDY: FULL ARTICLE: Immunomodulating properties of gamma‐hydroxybutyrate (GHB), flunitrazepam and ethanol in ‘club drugs’ users

CLINICAL STUDY: FULL ARTICLE: Immunomodulating properties of gamma‐hydroxybutyrate (GHB), flunitrazepam and ethanol in ‘club drugs’ users

Could Lorazepam be More Effective in Alcohol Withdrawal than Other Benzodiazepines?

Alterations of Homocysteine Serum Levels during Alcohol Withdrawal Are Influenced by Folate and Riboflavin: Results from the German Investigation on Neurobiology in Alcoholism (GINA)

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