Alterations of Homocysteine Serum Levels during Alcohol Withdrawal Are Influenced by Folate and Riboflavin: Results from the German Investigation on Neurobiology in Alcoholism (GINA)

Heese, Peter; Linnebank, Michael; Semmler, Alexander; Muschler, Marc; Heberlein, Annemarie; Frieling, Helge; Stoffel‐Wagner, Birgit; Kornhuber, Johannes; Banger, Markus; Hillemacher, Thomas

doi:10.1093/alcalc/ags058

Cited by 20 publications

(19 citation statements)

References 29 publications

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“…The present study is part of the German Investigation on Neurobiology in Alcoholism (GINA) (Heese et al, 2012). Consecutive patients were recruited from the Department of Addiction and Psychotherapy of the LVR-Clinic in Bonn, Germany (Heese et al, 2012).…”

Section: Patientsmentioning

confidence: 99%

“…Consecutive patients were recruited from the Department of Addiction and Psychotherapy of the LVR-Clinic in Bonn, Germany (Heese et al, 2012). All participants were diagnosed with alcohol dependency according to and were included in the study on admission for alcohol detoxification.…”

Section: Patientsmentioning

confidence: 99%

“…As vitamin deficiency commonly occurs in alcoholdependent patients, alcohol-induced changes in DNA methylation and homocysteine might be explained by vitamin deficiencies (Cravo & Camilo, 2000;Heese et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…As homocysteine plasma levels strongly depend on serum levels of folate, vitamin B1, B6 and B12 (Heese et al, 2012;Mudd, Levy, & Kraus, 2001), homocysteine was not included in multivariate analyses. Bivariate Pearson analyses revealed no significant correlation between homocysteine plasma levels and DNA methylation on day 1 (p=0.626), day 3 (p=0.871) or day 7 (p=0.624).…”

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confidence: 99%

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Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: Results from the German Investigation on Neurobiology in Alcoholism (GINA)

Semmler

Heese

Stoffel‐Wagner

et al. 2015

Alcohol

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Recent studies have shown that smoking and alcoholism may be associated with altered DNA methylation and that alcohol consumption might induce changes in DNA methylation by altering homocysteine metabolism. In this monocenter study, we included 363 consecutive patients referred for hospitalization for alcohol detoxification treatment. Blood samples were obtained on treatment days 1, 3, and 7 for measurement of global DNA methylation in leukocytes by liquid chromatography tandem mass spectrometry. Genomic DNA was used for genotyping the following seven genetic variants of homocysteine metabolism: cystathionine beta-synthase (CBS) c. This suggests a direct effect of alcohol consumption and smoking on DNA methylation, which is not mediated by effects of alcohol on homocysteine metabolism.

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Section: Patientsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: Results from the German Investigation on Neurobiology in Alcoholism (GINA)

Semmler

Heese

Stoffel‐Wagner

et al. 2015

Alcohol

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“…[20][21][22] Homocysteine is of importance for DNA methylation as it is metabolized to methionine, which is then transformed into S-adenosyl methionine (SAM), the most important methyl group donor in vertebrates. 23 Consequently, elevated homocysteine levels were associated with DNA hypermethylation in alcohol dependent patients.…”

Section: Introductionmentioning

confidence: 99%

Validation of differential GDAP1 DNA methylation in alcohol dependence and its potential function as a biomarker for disease severity and therapy outcome

et al. 2016

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Alcohol dependence is a severe disorder contributing substantially to the global burden of disease. Despite the detrimental consequences of chronic alcohol abuse and dependence, effective prevention strategies as well as treatment options are largely missing to date. Accumulating evidence suggests that gene-environment interactions, including epigenetic mechanisms, play a role in the etiology of alcohol dependence. A recent epigenome-wide study reported widespread alterations of DNA methylation patterns in alcohol dependent patients compared to control individuals. In the present study, we validate and replicate one of the top findings from this previous investigation in an independent cohort: the hypomethylation of GDAP1 in patients. To our knowledge, this is the first independent replication of an epigenome-wide finding in alcohol dependence. Furthermore, the AUDIT as well as the GSI score were negatively associated with GDAP1 methylation and we found a trend toward a negative association between GDAP1 methylation and the years of alcohol dependency, pointing toward a potential role of GDAP1 hypomethylation as biomarker for disease severity. In addition, we show that the hypomethylation of GDAP1 in patients reverses during a short-term alcohol treatment program, suggesting that GDAP1 DNA methylation could also serve as a potential biomarker for treatment outcome. Our data add to the growing body of knowledge on epigenetic effects in alcohol dependence and support GDAP1 as a novel candidate gene implicated in this disorder. As the role of GDAP1 in alcohol dependence is unknown, this novel candidate gene should be followed up in future studies.

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Role of homocysteine in the development and progression of Parkinson’s disease

Fan

Zhang

et al. 2020

Ann Clin Transl Neurol

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Homocysteine is an essential intermediate product of biochemical reactions that is present in various tissues of the human body. Homocysteine may be associated with the development and progression of Parkinson's disease. Plasma homocysteine levels in patients with Parkinson's disease are elevated compared to those of healthy individuals. High homocysteine drives PD development and progression while aggregating the clinical symptoms of PD patients. The relationship between PD and homocysteine involves multiple pathways, including nerve cell apoptosis, oxidative stress, and DNA damage. This is crucial for explaining how high homocysteine drives the PD procession. Elevated homocysteine level during PD development and progression offers a new strategy for the diagnosis and treatment of this disease.

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Alterations of Homocysteine Serum Levels during Alcohol Withdrawal Are Influenced by Folate and Riboflavin: Results from the German Investigation on Neurobiology in Alcoholism (GINA)

Abstract: These findings show that not only BAC and plasma folate levels, but also plasma levels of riboflavin influence HCY plasma levels in alcohol-dependent patients.

Cited by 20 publications

References 29 publications

Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: Results from the German Investigation on Neurobiology in Alcoholism (GINA)

Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: Results from the German Investigation on Neurobiology in Alcoholism (GINA)

Validation of differential GDAP1 DNA methylation in alcohol dependence and its potential function as a biomarker for disease severity and therapy outcome

Role of homocysteine in the development and progression of Parkinson’s disease

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