Acute appendicitis secondary to metastatic breast cancer. 12 Years after first primary tumor diagnosis. A case report

Hughes, Victoria G.; Osácar, Pedro; Darío, Rubén

doi:10.1016/j.ijscr.2022.107452

Cited by 4 publications

(6 citation statements)

References 17 publications

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“…Notably, four cases specifically involved metastatic lobular carcinoma (Oldfield et al [36], Pigolkin et al [41], Dirksen et al [42], and Numan et al [5]), indicating a potential propensity for lobular carcinoma to metastasize to the appendix. In terms of hormone receptor status, when reported, ER positivity was predominant and found in cases like Hughes et al [9], Kwan et al [29], and Vincent De Pauw et al [3]. PR positivity and HER2 negativity were also commonly observed, underscoring the hormonal influence in these metastatic events.…”

Section: Appendicitis As a Presentation Of Metastatic Breast Cancer: ...mentioning

confidence: 93%

“…While primary tumors of the appendix, such as those detailed in certain case studies [7], are a distinct category of appendiceal malignancies, isolated metastasis to the appendix from other cancers is infrequent and primarily arises from peritoneal seeding [8]. Histologically, these metastatic cancers typically exhibit a pattern of gradual serosal invasion, while often sparing the mucosal layer [9]. In patients with a history of cancer, the prevalence of benign appendicular conditions, such as acute appendicitis and primary appendiceal tumors, far exceeds that of metastatic appendiceal tumors.…”

Section: Metastatic Involvement Of the Appendix: A Rare Occurrencementioning

confidence: 99%

“…For cases like acute appendicitis secondary to breast tumor metastasis, the standard treatment is appendectomy. There is a lack of consensus on whether right hemicolectomy offers better oncological outcomes than appendectomy in stage IV breast cancer patients [9]. The selection of therapeutic strategies underlines the importance of tailored treatment plans, adapting to the unique challenges presented by metastatic breast cancer, especially when it manifests in less common locations, such as the appendix.…”

Section: Therapeutic Strategies For Breast Cancer Metastasis To the A...mentioning

confidence: 99%

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Metastatic Breast Cancer Presenting as Acute Appendicitis: A Rare Case Study and Review of Current Knowledge

Markovic,

Stojanovic,

Jovanovic

et al. 2023

Diagnostics

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This manuscript discusses a rare case of acute appendicitis caused by metastasis from invasive breast carcinoma of no special type in a 70-year-old female previously diagnosed with breast cancer. It delves into the diagnostic challenges and management complexities of such unusual clinical presentations. The paper includes an analysis of 19 documented cases, enriching the understanding of metastatic patterns and treatment strategies in breast cancer. It underlines the importance of considering a history of malignancy when diagnosing acute abdominal conditions and emphasizes a comprehensive approach in interpreting diagnostic imaging in patients with past oncological issues to effectively manage metastatic breast cancer exhibiting atypical manifestations.

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Section: Appendicitis As a Presentation Of Metastatic Breast Cancer: ...mentioning

confidence: 93%

Section: Metastatic Involvement Of the Appendix: A Rare Occurrencementioning

confidence: 99%

Section: Therapeutic Strategies For Breast Cancer Metastasis To the A...mentioning

confidence: 99%

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Metastatic Breast Cancer Presenting as Acute Appendicitis: A Rare Case Study and Review of Current Knowledge

Markovic,

Stojanovic,

Jovanovic

et al. 2023

Diagnostics

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show abstract

“…Seventeen cases [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] of metastatic breast cancer causing appendicitis were identified. The age of the patients ranged from 35 up to 90 years old, with an average age of 54 years old.…”

Section: Breastmentioning

confidence: 99%

“…58.8% of the cases were complicated compared to 41.2% of uncomplicated appendicitis. Four cases were metastatic lobular carcinoma [10,12,18,20] and eleven cases were metastatic ductal carcinoma. One patient had ileocecectomy due to findings of dilated ileum intraoperatively along with oedematous appendix [10].…”

Section: Breastmentioning

confidence: 99%

Acute Appendicitis Secondary to Metastatic Malignancy - A Review of 78 Cases in Literature

2023

J Surg

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Background: Acute appendicitis is one of the most common causes of acute abdomen presentation to the emergency department. Appendicectomy is one of the most common emergency operations performed. Appendicitis is attributed to lymphoid hyperplasia or faecolith causing obstruction of the appendiceal lumen. Other causes include helminth infection, primary appendiceal tumours, malignancy, and calculi. Metastatic malignancy causing acute appendicitis is very uncommon. In this article, we review the literature that exists reporting acute appendicitis attributed to metastatic diseases of the appendix, the malignancies that were identified, and the nature of the presentation. Methods:This study was performed following the Scale for the Assessment of Narrative Review Articles (SANRA). A literature review of existing case reports, abstracts, and studies was performed. PubMed and Google Scholar were used to search for the articles. Several cases were identified using the 'snowball method' where references were used to identify additional published literature.Results: Seventy-eight cases of acute appendicitis secondary to metastatic malignancies were identified. The most commonly reported metastatic malignancy causing appendicitis were breast, lung, gastric, and prostate. There was a total of n=34 (46%) of individuals with complicated appendicitis, n=40 (54%) with uncomplicated appendicitis, and four cases did not have degree of inflammation documented. The mean age of the patients was 57 years old. Conclusion:Appendicitis secondary to metastatic disease is a rare entity. This literature review has collated data identifying known primary malignancies that are associated with metastatic disease to the appendix. The most common have been identified as breast, lung, gastric and prostate primary malignancies. The mean age of patients in this review is 57. Patients presented with more complicated disease in comparison to the general population with acute appendicitis without malignancy. While rare, it important to be cognizant to the patient's previous malignancies even after the surveillance period has been completed. In this article we review the literature that exists reporting acute appendicitis attributed to secondary metastatic disease of the appendix, the malignancies that were identified and the nature of the presentation. When considering management of appendicitis, it is important to be cognizant as to whether the patient has had previous malignancies even after the surveillance period is over.

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Acute Appendicitis Caused by Metastasis from Other Organs: A Systematic Review

Aoun,

Akel,

Kassar

et al. 2023

J Gastrointest Canc

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Acute appendicitis secondary to metastatic breast cancer. 12 Years after first primary tumor diagnosis. A case report

Cited by 4 publications

References 17 publications

Metastatic Breast Cancer Presenting as Acute Appendicitis: A Rare Case Study and Review of Current Knowledge

Metastatic Breast Cancer Presenting as Acute Appendicitis: A Rare Case Study and Review of Current Knowledge

Acute Appendicitis Secondary to Metastatic Malignancy - A Review of 78 Cases in Literature

Acute Appendicitis Caused by Metastasis from Other Organs: A Systematic Review

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