“…Acute appendicitis is a common surgical emergency, but it is rare to get acute appendicitis due to S. typhi. Cases of acute appendicitis due to drug-sensitive S. typhi in children and adults have been reported in the past [ 4 - 5 ]. With its emergence in 2018 in Hyderabad, Pakistan, 14,360 cases of extensively drug-resistant Salmonella typhi (XDR S. typhi) have been reported by the National Institute of Health (NIH), Pakistan [ 6 ].…”