Acute Anti-Ischemic Effect of Testosterone in Men With Coronary Artery Disease

Rosano, Giuseppe; Leonardo, Filippo; Pagnotta, Paolo; Pelliccia, Francesco; Panina, Gaia; Cerquetani, Elena; Monica, Paola Lilla Della; Bonfigli, B.; Volpe, Massimo; Chierchia, Sergio

doi:10.1161/01.cir.99.13.1666

Cited by 334 publications

(197 citation statements)

References 15 publications

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“…Indeed, testosterone infusion into the coronary arteries induces vasodilation, 76 and intravenous administration of testosterone reduces the exercise-induced ischemic response in men with stable angina. 77,78 Furthermore, acute administration of testosterone in men with chronic heart failure reduces peripheral vascular resistance and cardiac afterload, resulting in an increased cardiac index. 79 Chronic administration of testosterone also improves functional capacity and symptoms in heart failure patients.…”

Section: Clinical Effects Of Androgen Replacement Therapymentioning

confidence: 99%

Hormonal effects on blood vessels

Akishita

2012

Hypertens Res

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The incidence of cardiovascular disease (CVD) is lower in younger women than in men of the same age, but it increases after menopause, implicating the atheroprotective action of endogenous estrogen. Although observational studies have suggested the efficacy of estrogen therapy in postmenopausal women, placebo-controlled, randomized trials, such as the Women's Health Initiative, have not confirmed effects of estrogen therapy on CVD. Conversely, basic, experimental research has progressed and provided mechanistic insight into estrogen's action on blood vessels. By contrast, the vascular effects of androgens remain poorly understood and have been controversial for a long time. In recent years, an increasing body of evidence has suggested that androgens may exert protective effects against the development of atherosclerosis, at least in elderly men. Epidemiological studies have shown that the incidence of and mortality due to CVD were increased in elderly men with low testosterone levels, although the efficacy of androgen therapy remains unknown. Furthermore, recent experimental studies have demonstrated the direct action of androgens on the vasculature. In this review, we illustrate the effects of sex steroids on the cardiovascular system, focusing on the action of testosterone on the blood vessels.

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Section: Clinical Effects Of Androgen Replacement Therapymentioning

confidence: 99%

Hormonal effects on blood vessels

Akishita

2012

Hypertens Res

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“…22,28 The lower testosterone and higher prolactin levels in females are in accordance with vasoconstriction and therefore with increased DBP reactivity and TPR reactivity. 40 This may interfere with blood pressure, and these parameters are therefore associated with the high rate of hypertension in stratum 3 subjects.…”

Section: Malesmentioning

confidence: 99%

“…32,[36][37][38] It is also reported that the vasorelaxing effect of testosterone is endothelium independent, with the possible involvement of potassium channel modulation. 39,40 There is a pressing need for epidemiological studies in Africa, to determine the risk factors for the development of hypertension in specific living circumstances. 41 This part of the transition and health during urbanization in South Africans (THU-SA) study was designed to determine the changes in the cardiovascular and endocrine parameters that may be associated with the high incidence of cardio/cerebrovascular disease in subjects living in informal settlements, compared with the rural community.…”

Section: Introductionmentioning

confidence: 99%

Prolactin, testosterone and cortisol as possible markers of changes in cardiovascular function associated with urbanization

et al. 2002

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People living in large informal settlements in South Africa showed a significant increase in cardio/cerebrovascular disease. This study was undertaken to compare the cardiovascular and endocrine parameters of urbanized and rural black female and males. The hormone levels such as prolactin, cortisol and testosterone may also change with urbanization and could make a contribution to the high rate of hypertension. For this study, 1202 black subjects were selected from 37 randomly selected rural and urbanized settlements. Resting blood pressure was recorded with a Finapres apparatus. Cardiac output, stroke volume, heart rate, total peripheral vascular resistance and compliance had been obtained with the Fast Modelflow software program. An acute laboratory stressor (hand dynamometer exercise) was applied to challenge the cardiovascular system and the measurements were repeated. Blood sampling was done and hormone levels were determined by biochemical analyses. For females, significant lower levels of cortisol were found in the urban strata in comparison with the rural strata. The testosterone levels were significantly lower and the prolactin levels significantly higher for females in the informal settlements compared with the rural strata. It is noticeable that most cardiovascular parameters showed the highest changes with the application of the stressor in the informal settlement strata and the lowest in people living on farms for both male and female. The prolactin levels in males are significantly higher in the informal settlement stratum. Subjects living in informal settlements showed a noticeable endocrine pattern of ongoing stress that can be associated with changes in the cardiovascular parameters with urbanization. This can partly explain the reported high rate of cardio/cerbrovascular disease in black South Africans living in informal settlements.

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“…Several studies support direct anti-anginal properties of T. T infusion has been related to coronary artery dilation and increased coronary blood flow, probably through inhibition of Ltype Ca2 + channels [110,111]. Intravenous T administration 30 min before exercise as well as 2 weeks of T treatment by transdermal patch had a positive effect on exercise induced ischemia [112,113]. Low T levels have been described in patients with heart failure.…”

Section: Cardiovascular Diseasementioning

confidence: 93%

A view of geriatrics through hormones. What is the relation between andropause and well-known geriatric syndromes?

Samaras

Lang

et al. 2013

Maturitas

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a b s t r a c tAge related male hypogonadism, or "andropause", is increasingly recognized as of frequent occurrence in older patients. Diagnosis requires both the presence of clinical symptoms and low testosterone levels. However, diagnosing andropause in this age group may be challenging since symptoms are frequently non specific and testosterone levels are influenced by a multitude of parameters such as lifestyle factors and chronic diseases. In this article we discuss the pathophysiology, definition and diagnostic difficulties of andropause in geriatric patients. Moreover, we review the relation between testosterone levels and frequent geriatric syndromes such as falls, osteoporosis, cognitive and mood disorders, anemia and cardiovascular disease. Finally, we examine the potential benefits and risks of testosterone replacement therapy in this age group.

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Acute Anti-Ischemic Effect of Testosterone in Men With Coronary Artery Disease

Abstract: Short-term administration of testosterone induces a beneficial effect on exercise-induced myocardial ischemia in men with coronary artery disease. This effect may be related to a direct coronary-relaxing effect.

Cited by 334 publications

References 15 publications

Hormonal effects on blood vessels

Hormonal effects on blood vessels

Prolactin, testosterone and cortisol as possible markers of changes in cardiovascular function associated with urbanization

A view of geriatrics through hormones. What is the relation between andropause and well-known geriatric syndromes?

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