Prolactin, testosterone and cortisol as possible markers of changes in cardiovascular function associated with urbanization

Huisman, Hugo W.; Rooyen, Johannes M. Van; Malan, Nicolaas T.; Eloff, F.C.; Malan, Leoné; Laubscher, P; Schutte, Aletta E.

doi:10.1038/sj.jhh.1001493

Cited by 15 publications

(18 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prolactin may increase arterial stiffness through changes in vascular tone, induction of low-grade inflammation, and smooth muscle cell proliferation [32][33][34][35][36] and may, thus, influence central and peripheral hemodynamics. Because prolactin is considered a hormone associated with stress, 37 mental stress may be a potential mechanism linking higher levels of this hormone with high blood pressure. However, there was no correlation of prolactin with heart rate, a parameter strongly correlated with mental stress.…”

Section: Discussionmentioning

confidence: 99%

Prolactin and Preclinical Atherosclerosis in Menopausal Women With Cardiovascular Risk Factors

et al. 2009

View full text Add to dashboard Cite

Abstract-Hyperprolactinemia has been associated with endothelial dysfunction and an adverse cardiovascular risk profile, possibly as a result of the vasoconstrictive properties of prolactin. In this cross-sectional study, we examined the hypothesis that prolactin contributes to the increased cardiovascular risk occurring in early menopause by studying apparently healthy women without hyperprolactinemia.

show abstract

Section: Discussionmentioning

confidence: 99%

Prolactin and Preclinical Atherosclerosis in Menopausal Women With Cardiovascular Risk Factors

et al. 2009

View full text Add to dashboard Cite

show abstract

“…[1][2][3] An increase in blood pressure could be the result of many factors, including age, environmental factors (such as stress and socioeconomic status), genetic factors, diet, unhealthy lifestyle and functional and structural alterations of the arterial wall because of haemodynamic and/or humoral factors, including oxidative stress. 4,5 An increase in reactive oxygen species (ROS) causes oxidative stress, and contributes significantly to the functional and structural alterations present in hypertension. 4 Large amounts of ROS produced by vascular cells, including superoxide ( K O 2 À ) and hydrogen peroxide (H 2 O 2 ), act as important intracellular signals.…”

Section: Introductionmentioning

confidence: 99%

Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study

et al. 2011

Self Cite

View full text Add to dashboard Cite

Many mechanisms, including oxidative stress, contribute to hypertension. This study investigated the possible associations between oxidative stress, blood pressure and arterial stiffness in black South Africans. Ambulatory blood pressure measurements were taken for 101 black South African men and 99 women. The stiffness indices included ambulatory arterial stiffness index (AASI) and pulse pressure (PP). Reactive oxygen species (ROS) levels (Po0.0001) were higher in the African women compared with men. ROS levels were also higher in hypertensive compared with normotensive men. The 24 h systolic blood pressure (SBP; Po0.01), 24 h diastolic blood pressure (DBP; Po0.0001) and pulse wave velocity (PWV; Po0.01) were significantly higher in African men compared with women. There were unadjusted positive associations of 24 h SBP (r ¼ 0.33; P ¼ 0.001), 24 h DBP (r ¼ 0.26; P ¼ 0.008) and 24 h PP (r ¼ 0.29; P ¼ 0.003) with ROS in African men only. A positive association between AASI and ROS existed only in hypertensive men (r ¼ 0.27; P ¼ 0.035), but became nonsignificant (B ¼ 0.0014; P ¼ 0.14) after adjustments. Adjusted, positive associations of 24 h SBP (B ¼ 0.181; P ¼ 0.018) and 24 h PP (B ¼ 0.086; P ¼ 0.050) with ROS were again only evident in African men. ROS is positively associated with SBP and PP in African men, suggesting that increased ROS levels may contribute to hypertension in this population group.

show abstract

“…1 For a few decades, noninvasive finger arterial BP measurement (Finapres/ Portapres) has become an accepted technology, widely used in different areas of research, ranging from basic research, such as autonomic control of cardiovascular function, hypertension, pharmacology and psychophysiology, to use in the operating room, clinical practice, aero-and space research. [2][3][4] It has been shown that the vascular unloading technique of Penáz together with the Physiocal criteria of Wesseling provides reliable, noninvasive and continuous estimates of BP. [5][6][7] However, previous studies 7 have indicated that although the Finapres fulfilled the accuracy requirements for the mean and diastolic mean difference (+1.7 mmHg (s.d.…”

Section: Introductionmentioning

confidence: 99%

Validation of the Finometer device for measurement of blood pressure in black women

et al. 2004

Self Cite

View full text Add to dashboard Cite

The improved Finapres apparatus, known as the Finometer, measures finger blood pressure noninvasively on a beat-to-beat basis and gives waveform measurements similar to intra-arterial recordings. The Finometer measures brachial pressure and corrects for finger pressure accordingly. It also corrects for the hydrostatic height of the finger with respect to the heart level. The objective was to validate the Finometer according to the revised British Hypertension Society (BHS) protocol and the criteria of the Association for the Advancement of Medical Instrumentation (AAMI). We carried out a main validation test using a subject group of 102 black women, which was also divided into smaller groups, namely 24 hypertensives, 25 obese normotensive and 35 lean normotensive women. Finometer and mercury sphygmomanometer blood pressure (BP) measurements were taken early in the morning before breakfast, after the subjects stayed overnight in a research unit. Within the whole subject group, the Finometer satisfied the AAMI criteria for accuracy and achieved an overall A/B grading according to the BHS criteria. The sphygmomanometer measurements were 128 7 20/ 78 7 12 mmHg compared to 130 7 20/78 7 11 mmHg for the Finometer. The average differences between the mercury sphygmomanometer and Finometer readings for systolic and diastolic BP were, respectively, À1.83 7 6.8 and 0.88 7 7.5. Systolic readings of the Finometer device differed by less than 5 mmHg for 64%, by less than 10 mmHg for 86% and differed by less than 15 mmHg for 96% of all readings. A total of 63% of all diastolic readings of the Finometer by less than 5 mmHg, 85% by less than 10 mmHg and 94% of all readings differed by less than 15 mmHg. On the basis of these results, the Finometer device satisfied the validation criteria of AAMI and received an A/B grading according to the BHS protocol. It can therefore be recommended for measurements in the clinical set-up and for research purposes.

show abstract

Prolactin, testosterone and cortisol as possible markers of changes in cardiovascular function associated with urbanization

Cited by 15 publications

References 45 publications

Prolactin and Preclinical Atherosclerosis in Menopausal Women With Cardiovascular Risk Factors

Prolactin and Preclinical Atherosclerosis in Menopausal Women With Cardiovascular Risk Factors

Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study

Validation of the Finometer device for measurement of blood pressure in black women

Contact Info

Product

Resources

About