Acute and subchronic toxicity of ethylene glycol monobutyl ether.

Tyler, T. R.

doi:10.1289/ehp.8457185

Cited by 40 publications

(10 citation statements)

References 7 publications

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“…No teratogenicity was seen in either species at any of the exposure concentrations employed. In rats at 100 and 200 ppm, the finding of maternal hematuria and/or hemoglobinuria seen early in the exposure period and evidence of anemia confirms and extends the work done previously in rats (13,14). The reduced red blood cell count, elevated hemoglobin and hematocrit, increased cell size and increased hemoglobin per cell found at sacrifice in rats at 100 and 200 ppm are consistent with destruction of mature erythrocytes and release of immature and/or young erythrocytes into the peripheral circulation (13,15).…”

Section: Discussionsupporting

confidence: 88%

Teratologic evaluation of ethylene glycol monobutyl ether in Fischer 344 rats and New Zealand white rabbits following inhalation exposure.

Tyl¹,

Millicovsky²,

Dodd³

et al. 1984

Environ Health Perspect

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Timed-pregnant Fischer 344 rats and New Zealand White rabbits were exposed to ethylene glycol monobutyl ether vapors by inhalation on gestational days 6 through 15 (rats) or 6 through 18 (rabbits) at concentrations of 0, 25, 50, 100 or 200 ppm. The animals were sacrificed on gestational day 21 (rats) or 29 (rabbits). In rats, exposure to 200 or 100 ppm resulted in maternal toxicity (clinical signs, decreased body weight and weight gain, decreased absolute and relative organ weights, decreased food and water consumption and evidence of anemia), embryotoxicity (increased number of totally resorbed litters and decreased number of viable implantations per litter) and fetotoxicity (reductions in skeletal ossification). No increase in fetal malformations was observed in any exposure group relative to controls. At 50 or 25 ppm, there was no maternal, embryo or fetal toxicity (including malformations) in rats. In rabbits, exposure to 200 ppm resulted in maternal toxicity (apparent exposure-related increases in deaths and abortions, clinical signs, decreased weight during exposure and reduced gravid uterine weight at sacrifice) and embryotoxicity (reduced number of total and viable implantations per litter). No treatment-related fetotoxicity was seen. No treatment-related increases in fetal malformations or variations were seen at any exposure concentration tested. There was no evidence of maternal, embryo, or fetal toxicity (including malformations) at 100, 50 or 25 ppm in rabbits.

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Section: Discussionsupporting

confidence: 88%

Teratologic evaluation of ethylene glycol monobutyl ether in Fischer 344 rats and New Zealand white rabbits following inhalation exposure.

Tyl¹,

Millicovsky²,

Dodd³

et al. 1984

Environ Health Perspect

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show abstract

“…The compound causes hemolysis and reduced hemoglobin concentration and red blood cell count in laboratory animals (IS,21). In contrast to the lower homologues 2-methoxyethanol and 2-ethoxyethanol, butoxyethanol does not appear to be teratogenic (15,20).…”

mentioning

confidence: 99%

Percutaneous absorption of 2-butoxyethanol in man.

Johanson¹,

Boman²,

Dynesius³

1988

Scand J Work Environ Health

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“…It appears to be much less hazardous than the shortchained alkoxyethanols with regard to reproductive effects (19,23,24). No sensitive method to determine 594 the alkoxyethanols in biological specimens was available.…”

mentioning

confidence: 99%

Toxicokinetics of inhaled 2-butoxyethanol (ethylene glycol monobutyl ether) in man.

Johanson¹,

Kronborg²,

Näslund³

et al. 1986

Scand J Work Environ Health

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JOHANSON G, KRONBORG H, NAsLUND PH , BYFALT NORDQVIST M. Toxicokin etics of inhaled 2-butoxyethanol (ethylene glycol monobutyl ether) in man . Scand J Work Environ Health 12 (1986) 594-602. Seven male volunteers were exposed to 2-butoxyethanol at the Swedish occupational exposure limit (20 ppm or 0.85 mrnol /rnt) during light physical exercise (50 W) on a bicycle ergometer. The exposure took place in an exposure chamber and lasted 2 h. Expired air was collected at regular time intervals for estimation of the respiratory uptake of the solvent. Arterialized capillary blood and urine were sampled during and after the exposure period and analyzed for 2-butoxyethanol and its metabolite butoxyacetic acid. A new sensitive method for analyzing 2-butoxyethanol in biological specimens is described . 2-Butoxyethanol was derivatized with pentafluorobenzoyl chloride and analyzed by gas chromatography with electron capture detection. The respiratory uptake of 2-butoxyethanol averaged 10.1 /lmollmin or 57 010 of the inspired amount. The concentration in blood reached a plateau level of 7.4 /lmolli. The apparent values of elimination half-t ime, mean residence time, total blood clearance, and steady-state volume of distribution were 40 min , 42 min , 1.2 l1min and 541, respecti vely. The amount of 2-butoxyethanol excreted in urine was less than 0.03 010 of the total uptake, while that of butoxyacetic acid ranged from 17 to 55 010.

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Acute and subchronic toxicity of ethylene glycol monobutyl ether.

Cited by 40 publications

References 7 publications

Teratologic evaluation of ethylene glycol monobutyl ether in Fischer 344 rats and New Zealand white rabbits following inhalation exposure.

Teratologic evaluation of ethylene glycol monobutyl ether in Fischer 344 rats and New Zealand white rabbits following inhalation exposure.

Percutaneous absorption of 2-butoxyethanol in man.

Toxicokinetics of inhaled 2-butoxyethanol (ethylene glycol monobutyl ether) in man.

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