Acute and Subchronic Evaluation of Aqueous Extracts of &lt;em&gt;Newbouldia laevis&lt;/em&gt; (Bignoniaceae) and &lt;em&gt;Nauclea latifolia&lt;/em&gt; (Rubiaceae) Roots used Singly or in  Combination in Nigerian Traditional Medicines

Ogbonnia, Steve; Mbaka, G. O.; Nkemehule, Florence E.; Emordi, J.E.; Okpagu, N. C-S.; Ota, Da

doi:10.19026/bjpt.5.5415

Cited by 14 publications

(11 citation statements)

References 23 publications

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“…Herbal remedies, especially in the form of teas or extracts,used for the treatment of various diseases are gaining increasing popularity. This is mostly attributed to their potency and availability [2]. Phytomedicines are currently recognized as the most common form of alternative medicine used by about 60% of the world population both in the developing and in the developed countries where modern medicines are predominantly in use [3].…”

Section: Introductionmentioning

confidence: 99%

Potential of Centella asiatica leaf extract in the management of paracetamol-induced jaundice in albino rats

Uchechi¹,

Uchenna²,

Precious³

et al. 2020

World J. Adv. Res. Rev.

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Jaundice is a condition associated with the imbalance between bilirubin production and excretion when the liver is diseased. This study investigated the Potential of Centella asiatica leaf extract in the management of paracetamolinduced jaundice in albino rats. The rats were randomly distributed into six groups of five each. Group 1 (normal control-fed with rat feed and water), group 2 (paracetamol 2 g/kg body weight), group 3 (paracetamol 2g/kg bw + silymarin 100 mg/kg bw) and groups 4 -6 (2g/kg bw each + 200, 400 and 600 mg/kg bw of CaL-extract respectively). The Paracetamol was first administered to the rats for 5 days to establish jaundice followed by administration of silymarin and CaL-extract for 10 days before sacrifice. The group 2 (negative control) rats had significant increase (p<0.05) in glucose level (7.50±0.10 mmol/L) and haematological parameters like haemoglobin (8.65±0.15g/dL), packed cell volume (26.15±0.95%), red blood cell (3.75±0.05x10 12 /L) and platelet (248.00±1.00 x10 9 /L) as well as elevated levels of serum lipids (LDL, TG,TC VLDL-cholesterol) when compared with group 3 and the CaL-treated groups. Results of the liver function maker enzymes (AST, ALT and ALP) activity, serum bilirubin and proteins as well as renal function indices (creatinine, urea, chloride and bicarbonate) in group 2 were significantly increased (p<0.05); while endogenous antioxidant study, revealed low levels of catalase (1.24±0.02µmol/ml), superoxide dismutase (0.17±0.02unit/ml) and reduced glutathione (0.84±0.18mg/ml) when compared to the treated groups. Administration of the CaL-extract and silymarin ameliorated the paracetamol-induced jaundice in albino rats.

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Section: Introductionmentioning

confidence: 99%

Potential of Centella asiatica leaf extract in the management of paracetamol-induced jaundice in albino rats

Uchechi¹,

Uchenna²,

Precious³

et al. 2020

World J. Adv. Res. Rev.

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“…The discovery since prehistoric era that plants products, in addition to their nutritive values, could serve as therapeutic weapons against various human, animal and even plant diseases has made plants a sine qua non to human and animal lives [1], and has led to the formulations of many herbal and/or polyherbal medicines. Polyherbs are plantsderived herbal medicines popularly known as "polyherbal drugs or phytomedicines", and are currently renowned and recognized as the most common form of alternative medicines in recent years [2,3]. According to Pieme et al [4], they are herbal recipes in the form of teas or extracts often prepared from the combinations of two or more plants and/or plant-products that contain active constituents with multiple physiological activities.…”

Section: Introductionmentioning

confidence: 99%

Depletion of Hepatic Antioxidant Enzymes in Experimental Albino Rats Due to Polyherbal Medicines Administration

Emaleku¹

2018

J Stem Cell Res Ther

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Objective: Plants and their derived products have served as veritable sources of foods and medicines for humans and animals from the outset, and the emergency of polyherbs (plants-derived products) in recent years has received the widest publicity and patronage by the Nigerian population as alternative medicines. It is not over statement to say many of them lack empirical data or validation to support the upsurge and prevalence in their usage as folk medicines, and little or no scientific data exist on their potential side effects. This study therefore investigates "the effects of some of these polyherbal drugs on hepatic antioxidants in experimental rats". Methods: Eight of the nine groups containing five animals each used for this study were administered eight different polyherbal drugs following different manufacturer's recommended dosage, while the ninth group served as control with no polyherb treatment. The study lasted for seven weeks i.e. forty-nine days, and on the 50th day, the animals were sacrificed after 12 h of previous overnight fasting, and their livers were excised for antioxidant assays. Results: Fidson bitters and Asheitu Adams blood purifier (ABP) significantly decreased superoxide oxidase (SOD) and glutathione-S-transferase (GST), while Yoyo bitter and Asheitu Adams formula for diabetes (AD) mostly decreased reduced glutathione (GSH) in a non-significant manner at (p<0.05). Conclusion: All polyherbal medicines caused depletion of hepatic antioxidant enzymes (SOD and GST), which is an indication of oxidative stress condition, but some of them improved non-enzymatic antioxidants like malondialdehyde (MDA) and vitamin C.

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“…The use of herbal remedies especially in the form of teas or extracts for the treatment of various diseases is gaining increasing popularity. Their increasing popularity may likely be due to their advantages of being efficacious and a cheap source of medical care 4 . The WHO Expert Committee 5 recommends appropriate use of herbal medicines and encourages the use of herbal drugs that have been proven to be safe and effective.…”

Section: Introductionmentioning

confidence: 99%

“…Herbal medicines are prepared and dispensed by traditional medicine practitioners. Only a few of these preparations have been tested and evaluated scientifically for safety 4 . There is therefore the need for a scientific evaluation of plants used in traditional medicine for safety.…”

Section: Introductionmentioning

confidence: 99%

“…Upon exposure, the clinical toxicity may vary from mild to severe and even life threatening making the safety and toxicity evaluations of these preparations necessary. Therefore, the potential toxicity of medicinal plants employed in the treatment of diseases over a long period of time demands that the practitioners should be kept abreast of the reported incidence of renal and hepatic toxicity associated with the ingestion of medicinal herbs 4,8 . For a plant or herbal preparation containing active organic principles to be identified for use in traditional medicine especially for long term treatment, a systemic approach is required for the evaluation of efficacy and safety through experiment and clinical findings 9 .…”

Section: Introductionmentioning

confidence: 99%

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Acetone Extract of Crinum Jagus Bulbs (Lilliaceae): An Acute and Sub Chronic Toxicological Evaluation in Albino Rats

Shorinwa¹,

Ebong²,

Obianime³

et al. 2014

Int. Res. J. Pharm.

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The bulbs of Crinum jagus bulbs are used in the treatment of various ailments in traditional medicine. This study was aimed at evaluating the toxicity of acetone extracts of Crinum jagus bulbs on albino rats following acute and sub-chronic exposure on haematological and biochemical parameters. The LD50 of this plant was estimated to be more than 5000 mg/kg. Phytochemical screening of the bulbs extract revealed the presence of flavonoids, tannins, saponins, steroids, alkaloids, carbohydrates, reducing sugars and saponins. In the repeated dose 28 days oral toxicity study, administration of 250 and 500 mg/kg of body weight of extracts revealed increase in body weights. The extract produced a significant (P < 0.05) increase in urea level and bicarbonate ion .There was a significant decrease (P < 0.05) in the levels of alanine amino transferase (ALT), and aspartate amino transferase (AST)) in the group treated with 250 mg/kg of extract when compared with the control. No significant (P > 0.05) changes in alkaline phosphatase, total bilirubin, total cholesterol, conjugated bilirubin, total protein and haematological parameters of the treated groups compared with control were observed. The plant extract is however, not safe for long term use.

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Acute and Subchronic Evaluation of Aqueous Extracts of <em>Newbouldia laevis</em> (Bignoniaceae) and <em>Nauclea latifolia</em> (Rubiaceae) Roots used Singly or in Combination in Nigerian Traditional Medicines

Cited by 14 publications

References 23 publications

Potential of Centella asiatica leaf extract in the management of paracetamol-induced jaundice in albino rats

Potential of Centella asiatica leaf extract in the management of paracetamol-induced jaundice in albino rats

Depletion of Hepatic Antioxidant Enzymes in Experimental Albino Rats Due to Polyherbal Medicines Administration

Acetone Extract of Crinum Jagus Bulbs (Lilliaceae): An Acute and Sub Chronic Toxicological Evaluation in Albino Rats

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