Acute and subchronic effects of pimozide on isolation-induced aggression in male mice

Navarro, José Francisco; Velasco, Raquel; Manzaneque, Juan M.

doi:10.1016/s0278-5846(99)00076-7

Cited by 10 publications

(7 citation statements)

References 16 publications

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“…The pharmacological manipulation of DA neural signaling has been shown to modulate aggressive behavior in various species and animal models of aggression (Aguilar, Miñarro, Pérez-Iranzo, & Simón, 1994; Arregui et al, 1993; Garmendia, Sánchez, Azpiroz, Brain, & Simón, 1992; Navarro & Manzaneque, 1997; Navarro, Miñarro, & Simón, 1993; Navarro, Velasco, & Manzaneque, 2000), including hamsters administered AAS during adolescent development (Schwartzer & Melloni, 2010a, 2010b). In recent studies we have shown that the central blockade of DA D2 receptor signaling within the LAH brain region effectively suppresses the high levels of offensive aggression observed in hamsters administered moderate doses of AAS during adolescence, while leaving other social, comfort, and locomotor behaviors unaffected (Schwartzer & Melloni, 2010a, 2010b).…”

Section: Discussionmentioning

confidence: 99%

Dopamine D2 receptors act upstream of AVP in the latero-anterior hypothalamus to modulate adolescent anabolic/androgenic steroid-induced aggression in Syrian hamsters.

Morrison¹,

Ricci²,

Melloni³

2015

Behavioral Neuroscience

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In pubertal male Syrian hamsters, exposure to anabolic/androgenic steroids (AAS) during adolescence facilitates a high level of offensive aggression modulated by the enhanced development and activity of the vasopressin (AVP) and dopamine (DA) neural systems within the latero-anterior hypothalamus (LAH), i.e., a brain region implicated in the control of aggression. The present studies provide a detailed report of the pharmacologic interactions between AVP and DA D2 receptor signaling within the LAH in the control of adolescent AAS-induced offensive aggression. Male Syrian hamsters were treated with AAS throughout adolescence and tested for aggression after local infusion of the DA D2 receptor antagonist eticlopride (ETIC) alone, or in combination with AVP in the LAH in an effort to determine the influence of DA D2 receptors relative to AVP-receptor mediated aggression mechanisms. As previously shown, ETIC infusion into the LAH suppressed adolescent AAS-induced aggressive responding; however, the AAS-induced aggressive phenotype was rescued by the co-infusion of AVP into the LAH. These behavioral data indicate that interactions between AVP and DA neural systems within the LAH modulate the control of aggression following adolescent exposure to AAS and that DA D2 receptor signaling functions upstream of AVP in the LAH to control this behavioral response.

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Section: Discussionmentioning

confidence: 99%

Dopamine D2 receptors act upstream of AVP in the latero-anterior hypothalamus to modulate adolescent anabolic/androgenic steroid-induced aggression in Syrian hamsters.

Morrison¹,

Ricci²,

Melloni³

2015

Behavioral Neuroscience

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“…Aggressive behaviour is regulated by a variety of different neurotransmitter systems in the brain, such as serotonine [2,3], dopamine [4,5], GABA [6,7], opiates [8], or gammahydroxybutyrate [9,10]. However, it is now recognized that aggression may be also influenced by glutamate system.…”

Section: Introductionmentioning

confidence: 99%

Effects of LY379268, A Selective Agonist of mGLu2/3 Receptors, on Isolation-Induced Aggression in Male Mice

Navarro¹,

Luque²,

Martı́n-López³

2009

TOPHARMJ

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Recent studies indicate that glutamate metabotropic receptors (mGlu) 1 and 5 are involved in the regulation of aggressive behaviour. Brain distribution of mGlu2/3 receptors suggests that they may also play important roles in emotional responses, including aggression. This study examines the effects of LY379268 (0.25-4 mg/kg, ip), a selective agonist of the mGlu2/3 receptors, on agonistic interactions between male mice using an animal model of isolation-induced aggression. Individually housed mice were exposed to anosmic "standard opponents" 30 min after drug administration. Ten min of diadic interactions were staged between a singly housed and an anosmic mouse in a neutral area. The encounters were videotaped and the accumulated time allocated by subjects to ten broad behavioural categories was estimated using an ethologically based analysis. LY379268 (2 mg/kg) significantly reduced attack behaviour, as compared with the control group, without affecting immobility, whereas the highest dose of the drug (4 mg/kg) also decreased offensive behaviours (threat and attack), but with a marked increase of immobility (non-selective effect). These results indicate that mGlu2/3 receptors might be implicated in the modulation of aggression.

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“…Overall, the results of these studies indicate that SCH-23390 has antiaggressive effects but only at doses that markedly depress motor activity [Arregui et al, 1993;Rodrı´guez-Arias et al, 1998], whereas at low doses it is clearly ineffective [Pedraza and n Navarro, 1999]. Likewise, it has been reported that all examined dopaminergic antagonists with an anti-D2 profile (such as haloperidol, chlorpromazine, pimozide, spiperone or tiapride) show strong antiaggresive properties, although they differ by the amount of motor impairment produced [Arregui et al, 1993;Navarro et al, 1993Navarro et al, , 2000Manzaneque and Navarro, 1997;Navarro and Manzaneque, 1997]. Moreover, neuroleptic drugs with a mixed profile anti-D1/D2 (e.g., zuclopenthixol) and anti-D2/D3 (e.g, sulpiride or amisulpride) also exhibit an antiaggressive activity in laboratory animal models [Redolat et al, 1991;Martı´n-Lo´pez et al, 1993;Navarro, 1999a, 1999b].…”

Section: Introductionmentioning

confidence: 99%

Behavioral profile of L–741,741, a selective D4 dopamine receptor antagonist, in social encounters between male mice

Navarro

Luna

Pedraza

2003

Aggressive Behavior

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Although the role of dopamine D1-D2-D3 receptors in the modulation of aggression has been extensively documented, there is not information with respect to the implication of D4 receptor. The aim of this study was to examine the acute effects of L-741,741 (0.75, 1.5 and 3 mg/kg, i.p), a selective D4 receptor antagonist, on social encounters between male mice using an ethopharmacological approach. Ten min of diadic interactions were staged between a singly housed and an anosmic mouse in a neutral area. These encounters were videotaped and the accumulated time allocated by subjects to ten broad behavioral categories was estimated. Besides other behaviors, the aggressive and motor behaviors were evaluated 30 min after injection using an ethologically based analysis. L-741,741 did not affect significantly offensive behaviors (threat and attack), as compared with the control group. Likewise, motor and anxiety-related behaviors (such as social investigation, avoidance/flee or defense submission) were not altered after drug administration. These results suggest that dopamine D4 receptor is not involved in the modulation of aggressive behavior. Aggr. Behav. 29:552-557,

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Acute and subchronic effects of pimozide on isolation-induced aggression in male mice

Cited by 10 publications

References 16 publications

Dopamine D2 receptors act upstream of AVP in the latero-anterior hypothalamus to modulate adolescent anabolic/androgenic steroid-induced aggression in Syrian hamsters.

Dopamine D2 receptors act upstream of AVP in the latero-anterior hypothalamus to modulate adolescent anabolic/androgenic steroid-induced aggression in Syrian hamsters.

Effects of LY379268, A Selective Agonist of mGLu2/3 Receptors, on Isolation-Induced Aggression in Male Mice

Behavioral profile of L–741,741, a selective D4 dopamine receptor antagonist, in social encounters between male mice

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