Acute and Subacute Toxicity of Persicaria minor in Wistar Rats

Muhammad, Norliza; Mansor, Elliza; Sang, Yap Chuan; Shariffudin, Nor Syahira; Dahdi, Amri; Alias, Ahmad Fadhil; Mohamed, Norazlina; Shuid, Ahmad Nazrun; Babji, Abdul Salam; Soelaiman, Ima Nirwana

doi:10.3923/ajas.2013.47.55

Cited by 2 publications

(1 citation statement)

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“…Furthermore, this plant has flavonoid named quercetin that connected to the antioxidant activity of this plant (Christapher et al, 2015). Previous histological observation of the aorta for any changes or modifications indicated that the extract of Polygonum minus also known as Persicaria minor is quitely safe even at higher doses and had no acute toxicity (Muhammad et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

EFFECT OF Polygonum minus (KESUM) LEAVES ETHANOLIC EXTRACT ON HISTOPATHOLOGICAL CHANGES ON THE WALL AORTA OF MICE (Mus musculus) INDUCED BY CADMIUM CHLORIDE ANTIOXIDANT

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et al. 2020

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This study was conducted to investigate the protective effect Polygonum minus leaves extract on the histopathological changes on aorta wall of mice (Mus musculus) induced by cadmium chloride. Thirty male mice were divided into five groups and were administered via intragastric gavage with different treatments for 21 days. The treatment were Negative Control (CMC Na 0.5% solution + aquadest), Positive Control (CMC Na0.5% solution + 8 mg/kg bw of mercuric chloride), Treatment 1, 2, and 3 (200, 400, and 800 mg/kg bw of Polygonum minus leaves extract respectively + 8 mg/kg bw of cadmium chloride). The microscopec examine followed analyzed by One Way ANOVA continued with Duncan test for counting the amount of foam cell and the histopathological changes of wall aorta were examined by using Ifora Scoring method was analysed using Kruskal Wallis and continued with Mann-Whitney test. The result showed Polygonum minus leaves extract could protect wall aorta of mice from the damage effect of cadmium chloride. The best dose of Polygonum minus on this research was 400 mg/kg bw.

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Section: Introductionmentioning

confidence: 99%