Acute and subacute (28 days) oral toxicity assessment of the oil extracted from Acrocomia aculeata pulp in rats

Traesel, Giseli Karenina; Souza, Juliane Coelho de; Barros, Aline Lima de; Souza, Marcos Alexandre de; Schmitz, Wanderlei Onofre; Muzzi, Rozanna Marques; Oesterreich, Silvia Aparecida; Arena, Arielle Cristina

doi:10.1016/j.fct.2014.10.026

Cited by 84 publications

(58 citation statements)

References 21 publications

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“…Furthermore, the oils did not induce toxicogenetic damage, demonstrated by the fact that the frequency of comets and micronuclei did not increase at any of the tested doses. These findings confirm those reported in a study by Traesel et al (2014), who assessed the toxicological profile of A. aculeata PO in acute and subacute toxicity assays. Their results showed that the median lethal dose (LD 50 ) was over 2000 mg/kg and that doses of 150-1000 mg/kg did not alter hematologic, biochemical, or histologic parameters.…”

Section: Discussionsupporting

confidence: 82%

“…Determination of the acid values, transesterification, and characterization of methyl monoesters have been accomplished by Traesel et al (2014).…”

Section: Oil Productionmentioning

confidence: 99%

“…The list of tested plants includes Acrocomia aculeata, a plant native to South and Central America with demonstrated medicinal (Traesel et al, 2014(Traesel et al, , 2015 and nutraceutical (Lescano et al, 2015) properties.…”

Section: Introductionmentioning

confidence: 99%

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Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide

Magosso¹,

Carvalho

Shneider³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Acrocomia aculeata is a plant rich in antioxidant compounds. Studies suggest that this plant has anti-inflammatory, antidiabetic, and diuretic potential. We assessed the antigenotoxic, antimutagenic, immunomodulation, and apoptotic potentials of A. aculeata alone and in combination with an antitumor agent, cyclophosphamide. Swiss male mice (N = 140) were used. The animals were divided into 14 experimental groups as follows: a negative group, a positive group (100 mg/kg cyclophosphamide), groups that only received the oil extracted from the almond (AO) and from the pulp (PO) of A. aculeata at doses of 3, 15, and 30 mg/kg, and the associated treatment groups (oils combined with cyclophosphamide) involving pretreatment, simultaneous, and post-treatment protocols. Data suggest that both oils were chemopreventive at all doses, based on the tested protocols. The highest damage reduction percentages, observed for AO and PO were 88.19 and 90.03%, respectively, for the comet assay and 69.73 and 70.93%, respectively, for the micronucleus assay. Both AO and PO demonstrated immunomodulatory activity. The oils reduced the capacity of cyclophosphamide to trigger apoptosis in the liver, spleen, and kidney cells. These results suggest that A. aculeate AO and PO can be classified as a functional food and also enrich other functional foods and nutraceuticals with chemopreventive features. However, they are not appropriate sources for chemotherapeutic adjuvants, in particular for those used in combination with cyclophosphamide.

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Section: Discussionsupporting

confidence: 82%

“…Determination of the acid values, transesterification, and characterization of methyl monoesters have been accomplished by Traesel et al (2014).…”

Section: Oil Productionmentioning

confidence: 99%

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Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide

Magosso¹,

Carvalho

Shneider³

et al. 2016

Genet. Mol. Res.

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“…The results indicated a LD 50 of more than 2000 mg/kg and the absence of any clinical signs that could be associated with toxic effects (Traesel et al, 2014).…”

Section: Discussionmentioning

confidence: 88%

“…The OPAC dosages were based on our previous determination of the median lethal dose (LD 50 ), which was higher than 2000 mg/kg (Traesel, 2014). Five different dosages (2000, 1000, 500, 250, and 125 mg/kg) were tested.…”

Section: Experimental Groups and Dosagesmentioning

confidence: 99%

Assessment of the cytotoxic, genotoxic, and mutagenic potential of Acrocomia aculeata in rats

Traesel¹,

Castro²,

Silva³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Acrocomia aculeata (Jacq.) Lodd. ex Mart. is a plant species commonly used as a foodstuff and also for treating diseases, since it contains high concentrations of antioxidant compounds and monounsaturated fatty acids. Considering its ethnopharmacological relevance, the aim of the present study was to assess the cytotoxic, genotoxic, and mutagenic effects of an oil extracted from the pulp of A. aculeata (OPAC) in rats. In addition, a chromatographic characterization of the fatty acids present in OPAC was performed. Male and female Wistar rats were treated orally with 125, 250, 500, 1000, or 2000 mg/ kg/body weight OPAC. The effects of OPAC ingestion were determined by performing the comet assay and micronucleus test. The comet assay data demonstrated that OPAC did not increase the frequency or rate of DNA damage in groups treated with any of the concentrations assessed compared to that in the negative control group. In the micronucleus test, the animals treated did not exhibit any cytotoxic or mutagenic changes in peripheral blood erythrocytes. The results demonstrated that OPAC did not exhibit cytotoxic, genotoxic, or mutagenic effects in Wistar rats, thereby increasing the evidence for the safety of oil extracted from this plant.

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Assessment of the Physicochemical Properties and Oxidative Stability of Kernel Fruit Oil from the Acrocomia totai Palm Tree

Souza

Diório

Johann

et al. 2018

J Americ Oil Chem Soc

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This study investigated the effects of variations in oil contents and fatty-acid composition, density, viscosity, acid values, saponification values, specific oxidative stability, and antioxidant concentration of Acrocomia totai kernel oil during fruit maturation. Fatty acids were quantified using 1 H nuclear magnetic resonance (NMR) spectroscopy, gas chromatograph-flame-ionization detector (GC-FID), and Fourier transform Raman (FT-Raman) spectroscopy analyses. The results showed that all physicochemical characteristics and oil composition changed during the ripening stage. The CG-FID analysis showed a reduction in the unsaturated fatty-acid content (from 78.8% to 22.1%), with a proportional increase in the saturated fatty-acid contents (from 21.6% to 77.9%). The difference in the fatty-acid composition was confirmed by analysis of the 1 H NMR and FT-Raman spectra. The degree of unsaturation was calculated to determine the oxidative stability of oil. These results suggest that the fruit's maturation contributes to the specific oxidative stability. The antioxidant concentration revealed higher contents of carotenoids in the ripe fruit (0.16 mg of carotenoid per 100 g KERNEL ) when compared to the unripe fruit (0.05 mg of carotenoid per 100 g KERNEL ). In the total phenolics analysis, there was no change in concentration over ripening time. These results show that kernel oil has physicochemical properties comparable with high-quality commercial vegetable oils, suggesting that it is a promising alternative to conventional vegetable oils.

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Acute and subacute (28 days) oral toxicity assessment of the oil extracted from Acrocomia aculeata pulp in rats

Cited by 84 publications

References 21 publications

Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide

Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide

Assessment of the cytotoxic, genotoxic, and mutagenic potential of Acrocomia aculeata in rats

Assessment of the Physicochemical Properties and Oxidative Stability of Kernel Fruit Oil from the Acrocomia totai Palm Tree

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