Acute and Recurrent Vesicular Hand Dermatitis Not Pompholyx or Dyshidrosis

Storrs, Frances J.

doi:10.1001/archderm.143.12.1578

Cited by 28 publications

(16 citation statements)

References 13 publications

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“…34 Protein contact dermatitis is often caused by natural rubber latex gloves, although the number of patients clinically allergic to natural rubber latex has been significantly declining 45 or by exposure to foods. 52,53 It is a recurrent HE with vesicular eruptions, lasting for 2-3 weeks, with no relevant contact allergy and no documented irritant exposure likely to cause HE. Atopic HE occurs in patients with current or previous atopic dermatitis with a further increased risk to those with filaggrin mutations.…”

Section: Occupational Hementioning

confidence: 99%

“…It was previously referred to as pompholyx or dyshydrotic eczema; however, there are good arguments to abandon this terminology. 52,53 It is a recurrent HE with vesicular eruptions, lasting for 2-3 weeks, with no relevant contact allergy and no documented irritant exposure likely to cause HE. Fungus elsewhere on the body and dust mite allergy have been discussed as possible eliciting factors, though only explaining a minority of cases.…”

Section: Classificationmentioning

confidence: 99%

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Hand eczema: epidemiology, prognosis and prevention

Agner

Elsner

2019

Acad Dermatol Venereol

103

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Hand eczema (HE) is a heterogeneous and often chronic disease located to the hands and wrist, and frequently associated with eczema on the feet. The aetiology is diverse, and the eczema may present with a variety of clinical symptoms. Acute and chronic stages appear; severity varies from mild to moderate and severe, and flares may be frequently recurrent or rare. The divergent aetiology and varied morphology of HE is sometimes tricky and may be challenging to the dermatologist. This review has focus on epidemiology, prognosis and prevention of HE, and intends to point towards some practical advice on how to diagnose, inform and guide HE patients.

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Section: Occupational Hementioning

confidence: 99%

Section: Classificationmentioning

confidence: 99%

Hand eczema: epidemiology, prognosis and prevention

Agner

Elsner

2019

Acad Dermatol Venereol

103

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“…Sweat duct obstruction was first described by Fox as the cause of sweat dysfunction;1 therefore, he coined the concept of dyshidrosis (difficulty in sweating). Several publications within the last 135 years have shown absence of relationship between dermatosis and sweat glands, hence the term dyshidrosis has become strictly incorrect 2–5…”

Section: Introductionmentioning

confidence: 99%

Clinical profile of recurrent vesicular palmoplantar dermatitis in children and adolescents

Scotelaro-Alves

Fernandes

Ramos‐e‐Silva

2019

CCID

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BackgroundPreviously known as dyshidrosis, recurrent vesicular palmoplantar dermatitis (RVPD) is presented as severe eruption of nonerythematous, symmetrical vesicles or bullae located along the lateral sides of fingers, on the palmar or plantar areas, and developing into a chronic and recurrent condition. Although very frequently observed on the hands, there are no specific studies about such eczema in children and adolescents.ObjectivesTo report on the RVPD clinical profile in children and adolescents, and monitor the association of RVPD with seasonal variations, hyperhidrosis, atopy and nickel sulfate.Materials and methodsEighteen patients affected by RVPD were submitted to clinical and laboratory assessment through anamnesis, physical exam, mycological exam, patch test, complete blood count and serum IgE levels.ResultsSeven patients (38.9%) reported increased frequency of eruptions during the summer months; 12 patients (66.7%) presented hyperhidrosis; in 14 cases (77.8%), atopic factors were determined; reaction to nickel sulfate was positive in three patients (16.7%).ConclusionRVPD onset may occur at an early age, developing into a chronic and recurrent infection. Hyperhidrosis and atopic status was established in the clinical profile and no connection between nickel sulfate and RVPD was observed.

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“…Traditionally classification is based on aetiological factors (irritant, allergic, and atopic disease), the localization of the eczema (dorsum, palmar, fingers, and wrist), or morphological features (vesicular, hyperkeratotic, lichenification, and recurrent vesicular hand dermatitis). It is generally believed that this classification system is insufficient, which makes comparison of studies and therapeutic strategies difficult, and hampers the possibilities for better understanding and treating the disease (13, 14). It seems likely that hand eczema is a common phenotype expressing a variety of underlying diseases.…”

mentioning

confidence: 99%

Classification of atopic hand eczema and the filaggrin mutations

Giwercman¹,

Lerbæk²,

Bisgaard

et al. 2008

Contact Dermatitis

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Hand eczema is a common disease with various risk factors of which atopic dermatitis is known to be one of the most important. Recently, two mutations in the gene coding for filaggrin, a protein important for the skin barrier, have repeatedly been shown to be associated with atopic dermatitis. Moreover, one study point towards an association between the filaggrin null alleles and the subgroup of patients having both hand eczema and atopic dermatitis. For the remainder of hand eczema patients, still unknown genetic risk factors exist. We propose that in future, classification of atopic hand eczema should distinguish between patients with and without the filaggrin null alleles and to further differentiate between associations with type I allergy, type IV allergy and exposure to irritants, respectively. Furthermore, we suggest future studies of atopic hand eczema to analyse for the filaggrin mutations. We believe this will increase the possibility of subgrouping this otherwise heterogenic disease and thereby enable a better phenotype-genotype characterization of hand eczema. This could improve the preventive initiatives, secure better information of patients about the prognosis for their disease, and possibly enable targeted treatment.

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Acute and Recurrent Vesicular Hand Dermatitis Not Pompholyx or Dyshidrosis

Cited by 28 publications

References 13 publications

Hand eczema: epidemiology, prognosis and prevention

Hand eczema: epidemiology, prognosis and prevention

Clinical profile of recurrent vesicular palmoplantar dermatitis in children and adolescents

Classification of atopic hand eczema and the filaggrin mutations

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