Acute and long‐term pulmonary effects of platelet‐activating factor

Mencia‐Huerta, Jean Michel; Hosford, David; Braquet, P.

doi:10.1111/j.1365-2222.1989.tb02356.x

Cited by 16 publications

(3 citation statements)

References 127 publications

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“…It is thought that PAF is generated locally in the lung and that eosinophils accutnulate due to the strong chemotactic activity of PAF (5,22). In contrast, asthmatic patients without a history of recent symptoms displayed PAF generation within the limits of normal controls.…”

Section: Discussionmentioning

confidence: 99%

“…According to a current hypothesis PAF may play an important role in the pathogenesis of asthtna. It is thought that PAF is generated locally in the lung and that eosinophils accutnulate due to the strong chemotactic activity of PAF (5,22). Eosinophils frotn atopic patients have been shown to be more susceptible to the chemotactic activity of PAF than neutrophils (17).…”

Section: Discussionmentioning

confidence: 99%

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Enhanced production of platelet activating factor by peripheral granulocytes from children with asthma

Schauer

Koch

Michl

et al. 1992

Allergy

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Granulocytes from 23 asthmatic children aged 4-15 years and 32 age-matched healthy children were studied. Cells were purified by Dextran sedimentation and Percoll gradient centrifugation from heparinized blood. After in vitro stimulation by ionophore A23187 the amount of newly synthesized PAF and LTC4 was assessed by radio receptor assay or radioimmunoassay respectively. Eight patients had symptoms of asthma within the last 3 weeks before examination. Granulocytes from the symptomatic patients showed a significantly higher PAF generation (median 125 ng/10(6) cells, range 7-189 ng/10(6) cells) when compared to asymptomatic patients (p less than 0.001, median 14 ng/10(6) cells, range 6-33 ng/10(6) cells) or controls (p less than 0.001, median 11 ng/10(6) cells, range 3-26 ng/10(6) cells). In contrast, LTC4 generation was increased in both patient groups. The results suggest a regulatory role of PAF in the exacerbation of asthma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Enhanced production of platelet activating factor by peripheral granulocytes from children with asthma

Schauer

Koch

Michl

et al. 1992

Allergy

View full text Add to dashboard Cite

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“…Long-term infusion of PAF in guinea-pigs can lead to hyperpiasia of bronchial smooth muscle and mucous glands, changes reminiscent of those seen in human asthma [22]. For obvious ethical reasons, similar studies in humans will be difficult to undertake but are clearly a more relevant model of ongoing PAF release in inflamed asthmatic airways.…”

mentioning

confidence: 99%