Symptoms and mechanisms—Inflammation of the lung

Rylander, Ragnar

doi:10.1002/ajim.4700250107

Cited by 20 publications

(7 citation statements)

References 14 publications

(1 reference statement)

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“…[Rylander, 1986]. ODTS is not a hypersensitivity reaction and may occur in any person exposed to bacterial endotoxin, mycotoxin molds, or proteinase enzymes, if the exposure is great enough [Rylander, 1994]. Therefore, ODTS is much more common than FL, but tolerance to the effects of organic dusts can occur after repeated exposures, resulting in lower prevalence even though incidence is higher.…”

Section: Introductionmentioning

confidence: 99%

Work‐related respiratory symptoms in New Zealand farmers

et al. 2001

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Section: Introductionmentioning

confidence: 99%

Work‐related respiratory symptoms in New Zealand farmers

et al. 2001

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“…A retrospective study of 30 childhood cases over 20 years in Greece (10) speculated the possible role of pesticides; other toxicants have been implicated in older patients (11 (19) is one of several environmental fungi that produce very potent compounds toxic to humans and animals. The symptoms of farmworkers exposed to the agriculturally important fungi are well described and for S. chartarum include nasal and tracheal bleeding (in contrast to the alveolar bleeding discussed above), skin irritation, and alterations in white blood cell counts (20)(21)(22). Both toxic and inflammatory mechanisms appear to be involved.…”

Section: Introductionmentioning

confidence: 99%

“…This article is based on a presentation at the International Conference on Indoor Mold and Children held [21][22][23][24] April 1998 in Alexandria, Virginia.…”

mentioning

confidence: 99%

Overview of investigations into pulmonary hemorrhage among infants in Cleveland, Ohio.

Dearborn

Yike

Sorenson

et al. 1999

Environ Health Perspect

164

106

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Idiopathic pulmonary hemorrhage was diagnosed in 37 infants in the Cleveland, Ohio, area between 1993 and 1998. This rare disorder has been related to 12 deaths, including 7 originally thought to be sudden infant death syndrome. Thirty of the infants were African American, all of whom lived in a limited geographic area of eastern metropolitan Cleveland, an area of older housing stock. An investigation led by the Centers for Disease Control and Prevention has found an association with household exposure to a toxigenic mold, Stachybotrys chartarum, and other fungi. The rapidly growing lungs of young infants appear to be especially vulnerable to the toxins made by toxigenic molds. Environmental tobacco smoke was frequently present in the infants' homes and may be a trigger precipitating the acute bleeding. Stachybotrys, although not thought to be a common mold, is known to have a wide geographic distribution. An additional 101 cases of acute, idiopathic pulmonary hemorrhage have been reported in infants in the United States over the past 5 years. In this overview, the investigations are summarized, the clinical profile is described, the toxicity of S. chartarum is discussed, and pathophysiologic concepts are presented.

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“…8 Inflammation may therefore be considered an integrated effect of the total biological and chemical exposure load from an indoor environment. Hence, measurements of the inflammatory potential of dust samples from the indoor environment might be an attractive supplement or alternative to many chemical and biological single factor analyses presently used to evaluate the indoor climate.…”

mentioning

confidence: 99%

Inflammatory potential of dust from schools and building related symptoms

Allermann

2003

Occup Environ Med

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Aims: To test whether the inflammatory potential of dust samples might be used to differentiate schools with high and low prevalence of building related symptoms (BRS) among the occupants. Methods: Ten schools with high prevalence of BRS and 10 schools with low prevalence were selected. Dust collected from floors, horizontal surfaces, and exhaust outlets was tested at five concentrations on the lung epithelial cell line A549. The potency of the dust (PF) to stimulate IL-8 secretion was calculated from the initial linear part of the dose-response curves. The organic fraction of the dust samples was determined by incineration. Results: The schools with low prevalence of symptoms had a BRS% of 4.4-11.0 and the schools with high prevalence a BRS% of 19.6-31.9. The PF of floor dust and surface dust correlated, and the PF was associated with the organic content of the dust. The schools with low prevalence of symptoms had a significantly lower PF than the schools with high prevalence. Using the cut point value of 4.5 ng IL-8/mg floor dust, significantly more high prevalence schools were found above the cut point than below. Conclusion: The PF of the floor dust samples correlated significantly with the prevalence of symptoms in the schools. The content of endotoxin and microorganisms did not seem to explain the inflammatory potential of the dust or BRS, and the substances in the dust causing the inflammatory potential are presently unknown. N on-specific symptoms such as mucous membrane irritations in the eyes, nose, and the upper respiratory tract, cough, dryness of the skin, and symptoms such as headache, dizziness, fatigue and lethargy, and lack of concentration, have all been related to the quality of the indoor air or the indoor environment in non-industrial buildings like offices, schools etc.

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Symptoms and mechanisms—Inflammation of the lung

Abstract: The various phases of the lung inflammatory response to inhaled agents are reviewed and linked to the clinical symptoms and syndromes. Available data suggest that inflammation is the major reason for the symptoms appearing after organic dust exposure.

Cited by 20 publications

References 14 publications

Work‐related respiratory symptoms in New Zealand farmers

Work‐related respiratory symptoms in New Zealand farmers

Overview of investigations into pulmonary hemorrhage among infants in Cleveland, Ohio.

Inflammatory potential of dust from schools and building related symptoms

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