Acute and Chronic Tubulointerstitial Nephritis of Rheumatic Causes

Oliva-Dámaso, Néstor; Oliva-Damaso, Elena; Payan, J

doi:10.1016/j.rdc.2018.06.009

Cited by 20 publications

(14 citation statements)

References 84 publications

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“…The native renal pathology in our patient with lympho-histiocytic interstitial infiltration, focal tubular atrophy, and interstitial fibrosis (Figures 2a,b) strikingly resembles the characteristic histology observed in bowel biopsies from LRBA cases (6). In other autoimmune conditions such as the syndrome of tubulointerstitial nephritis and uveitis (TINU), rheumatoid arthritis, and vasculitis tubulointerstitial nephritis are the prototypic forms of renal affection (7,8).…”

Section: Discussionsupporting

confidence: 66%

Case Report: Exome Sequencing Reveals LRBA Deficiency in a Patient With End-Stage Renal Disease

et al. 2020

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Section: Discussionsupporting

confidence: 66%

Case Report: Exome Sequencing Reveals LRBA Deficiency in a Patient With End-Stage Renal Disease

et al. 2020

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“…Previous studies have shown that late-uveitis TINU syndrome is likely to be misdiagnosed as D-ATIN, since the 2 diseases are clinically and pathologically indistinguishable at the time of renal biopsy [47][48][49]. Although positive mCRP-Ab is regarded as helpful in distinguishing patients with TINU syndrome from those with D-ATIN, its diagnostic value is still limited (specificity 88% and sensitivity 64%) [48].…”

Section: Missed Diagnosis Of Late-uveitis Tinu Syndromementioning

confidence: 99%

Acute Kidney Injury Relevant to Tubulointerstitial Nephritis with Late-Onset Uveitis Superimposed by Thrombotic Microangiopathy: A Case Report and Review of the Literature

Zhao

Yang

et al. 2020

Kidney Dis

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Background: The syndrome of tubulointerstitial nephritis and uveitis (TINU) is an uncommon and multisystemic autoimmune disorder. This review reports a rare case of TINU being superimposed on thrombotic microangiopathy (TMA) and, by comparing with the available literature, also summarizes the clinical features, associated conditions, treatment, and outcome of patients with TINU. Summary: Herein, we report the case of a 37-year-old male patient with acute kidney injury (AKI) clinicopathologically identified as malignant hypertension-induced TMA superimposed by acute tubulointerstitial nephritis, which was suspected to be related to drug hypersensitivity. After treatment with oral prednisone combined with a renin-angiotensin system inhibitor, the patient achieved partial renal recovery and was withdrawn from hemodialysis. Recurrent AKI concomitant with new-onset asymptomatic uveitis was detected during routine clinical follow-up after cessation of prednisone. TINU was then diagnosed, and prednisone followed by cyclophosphamide was prescribed. The patient achieved better renal recovery than in the first round of treatment and maintained stable renal function afterward. By reviewing the literature, 36 cases were reported as TINU superimposed on other conditions, including thyroiditis, osteoarthropathy, and sarcoid-like noncaseating granulomas. Key messages: TINU could be complicated by many other conditions, among which TMA is very rare. When presented as AKI, kidney biopsy is important for differential diagnosis. The case also shows that recurrent AKI with concomitant uveitis after prednisone withdrawal strongly suggested the need for long-term follow-up and elongated prednisone therapy for TINU syndrome.

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“…Diabetic nephropathy is one of the most important complications in diabetic patients and has become the second cause of end-stage renal disease at present, the diagnosis of which is traditionally based on microalbuminuria (MA); 23 and renal failure is a pathological condition in which partial or complete loss of renal function is caused by various chronic kidney diseases in the later stages; 24 chronic nephritis is also called chronic glomerulonephritis, this form of nephritis develops slowly and causes few symptoms in its early stages. But as the condition gets worse, this condition can cause severe kidney damage and kidney failure, which may develop after a sudden disease; 25 heart failure, also known as congestive heart failure and congestive cardiac failure, is a decline in cardiac function caused by various heart diseases, including shortness of breath, fatigue, palpitation, edema of lower limbs, etc; 26 precordial pain is the primary cardiacrelated complaint, and it is a symptom that can be caused by many diseases; 27 eye diseases include retinal hemorrhage, papilledema and cataract; psychosis is defined as a condition that affects the way our brain processes information, which causes the patient to lose touch with reality; psychosis is a symptom, not an illness, mental or physical illness, substance abuse, or extreme stress or trauma can cause it; 28 anemia refers to a common clinical symptom when the volume of red blood cells in human peripheral blood is decreased below the lower limit of the normal range. In our research, the diagnosis of all of these diseases was based on the main complaint of the patient.…”

Section: Variable Definitionsmentioning

confidence: 99%

A Non-Invasive Prediction Model for Non-Alcoholic Fatty Liver Disease in Adults with Type 2 Diabetes Based on the Population of Northern Urumqi, China

Xue¹,

Yang²,

Zou³

et al. 2021

DMSO

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Background High prevalence of non-alcoholic fatty liver disease (NAFLD) occurs in type 2 diabetes mellitus (T2DM), and about 13% of diabetic patients eventually die of liver cirrhosis or liver cancer. The purpose of our research was to develop a non-invasive predictive model of NAFLD in adults with T2DM. Patients and Methods Adult patients diagnosed with T2DM during physical examination in 2018 in Urumqi were recruited, in total 40,921 cases. We chose questionnaire and physical measurement variables to build a simple, low-cost model. Variables were selected by the least absolute shrinkage and selection operator regression (LASSO). The features chosen by LASSO were used to build the nomogram prediction model of NAFLD. The receiver operating curve (ROC) and calibration were used for model validation. Results Determinants in the nomogram included age, ethnicity, sex, exercise, smoking, dietary ratio, heart rate, systolic blood pressure (SBP), BMI, waist circumference, and atherosclerotic vascular disease (ASCVD). The area under ROC of developing group and validation group was 0.756 (95% confidence interval 0.750–0.761) and 0.755 (95% confidence interval 0.746–0.763), respectively, and the P values of the two calibration curves were 0.694 and 0.950, suggesting that the nomogram had good disease recognition ability and calibration. Conclusion A nomogram constructed with accuracy can calculate the possibility of NAFLD in adults with T2DM. If validated externally, this tool could be utilized as a non-invasive method to diagnose non-alcoholic fatty liver in adults with T2DM.

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Acute and Chronic Tubulointerstitial Nephritis of Rheumatic Causes

Cited by 20 publications

References 84 publications

Case Report: Exome Sequencing Reveals LRBA Deficiency in a Patient With End-Stage Renal Disease

Case Report: Exome Sequencing Reveals LRBA Deficiency in a Patient With End-Stage Renal Disease

Acute Kidney Injury Relevant to Tubulointerstitial Nephritis with Late-Onset Uveitis Superimposed by Thrombotic Microangiopathy: A Case Report and Review of the Literature

A Non-Invasive Prediction Model for Non-Alcoholic Fatty Liver Disease in Adults with Type 2 Diabetes Based on the Population of Northern Urumqi, China

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