Acute and chronic toxicity of the benzoylurea pesticide, lufenuron, in the fish, Colossoma macropomum

Soares, Priscila Rafaela Leão; Andrade, André Lucas Corrêa de; Santos, Thamiris Pinheiro; Silva, Stephannie Caroline Barros Lucas da; Silva, Jadson Freitas da; Santos, Ana Maria Maciel dos; Souza, Elton Hugo Lima da Silva; Cunha, Franklin Magliano da; Teixeira, Valéria Wanderley; Cadena, Marília Ribeiro Sales; Sá, Fabrício Bezerra de; Júnior, Luiz Bezerra de Carvalho; Cadena, Pabyton Gonçalves

doi:10.1016/j.chemosphere.2016.07.033

Cited by 27 publications

(4 citation statements)

References 33 publications

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“…In fish exposed to a concentration of 0.1 mg/L of lefenuron, the b-wave amplitude was increased by 3-fold compared to the control. Interestingly, no changes were found in the electroretinogram in animals submitted to chronic treatment (4 months) with lefenuron (0.1 and 0.3 mg/L) [ 46 ]. The authors correlate this change in the electroretinogram in acute treatment with the vascular hemodynamic changes found in the gills.…”

Section: Pesticidesmentioning

confidence: 99%

Retinal Toxicity Induced by Chemical Agents

Araújo

Brito

Pereira-Figueiredo

et al. 2022

IJMS

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Vision is an important sense for humans, and visual impairment/blindness has a huge impact in daily life. The retina is a nervous tissue that is essential for visual processing since it possesses light sensors (photoreceptors) and performs a pre-processing of visual information. Thus, retinal cell dysfunction or degeneration affects visual ability and several general aspects of the day-to-day of a person’s lives. The retina has a blood–retinal barrier, which protects the tissue from a wide range of molecules or microorganisms. However, several agents, coming from systemic pathways, reach the retina and influence its function and survival. Pesticides are still used worldwide for agriculture, contaminating food with substances that could reach the retina. Natural products have also been used for therapeutic purposes and are another group of substances that can get to the retina. Finally, a wide number of medicines administered for different diseases can also affect the retina. The present review aimed to gather recent information about the hazard of these products to the retina, which could be used to encourage the search for more healthy, suitable, or less risky agents.

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Section: Pesticidesmentioning

confidence: 99%

Retinal Toxicity Induced by Chemical Agents

Araújo

Brito

Pereira-Figueiredo

et al. 2022

IJMS

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“…Vision-based functional studies in zebrafish [39] show reduced optomotor responses following developmental exposure to heavy metals [40] and endocrine disruptors [41,42] as well as altered retinal anatomy and photoreceptor ultrastructure after developmental PCB exposure [43]. Similarly, the eyes of the golden grey mullet were found to accumulate heavy metals [44,45], and electroretinograms identified altered retinal physiology in tambaqui after pesticide exposure [46]. Altered vision reduces feeding success and predator avoidance, two behaviors in fish that depend on a functioning visual system.…”

Section: Exposure To Pbs Water Did Not Alter Eye Developmentmentioning

confidence: 99%

The Importance of Assessing Water Quality in Tributaries: A Case Study in an Urban Waterway Using Zebrafish (Danio rerio)

Malik

Cohen

MacAvoy

et al. 2023

Water

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Tributaries are important for fish recruitment and diversity. Here, we examine the biological impact of inorganic and organic contaminants in Paint Branch stream (PBS), a tributary of the Anacostia river in Washington D.C. The Anacostia has suffered severe ecological damage because of decades of pollution and deposited wastewater runoff; however, PBS, which connects to the northern part of the river, is forested and less urbanized, suggesting higher water quality. However, the impact of PBS water on early fish development has not been studied. To address this question, we examined if chronic (28 day) exposure to water collected from PBS can support the proper early development of zebrafish (Danio rerio), a vertebrate model in toxicological studies. We assessed their overall growth and swimming behaviors and correlated these results with a water quality analysis. The water chemistry identified high levels of calcium, sodium, and nitrate in PBS water samples. A gas chromatography–mass spectroscopy analysis of extracted non-polar compounds in the water column revealed siloxanes (congeners D6–D10) were the only component identified with >90% certainty. In our fish experiments, we observed age-dependent increases in growth and eye development, consistent with normal development. In contrast, general swimming behaviors showed an early increase in angular velocity at 7 days postfertilization (dpf; p = 0.001) and a decreased total distance traveled at 14 dpf (p = 0.015) for PBS-treated larvae. Using the open field test, we observed that the PBS-treated fish made fewer visits to the edge at 7 (p = 0.01), 14 (p < 0.001), and 21 dpf (p = 0.038) and spent significantly more time at the edge at 21 dpf (p < 0.001). Fewer visits to the center were also noted at 14 and 21 dpf, suggesting reduced overall movement at these two ages in response to chronic PBS water exposure. Interestingly, by 28 dpf, no differences were noted in any parameter measured. Overall, these results indicate zebrafish larvae grew well in PBS water; however, their reduced movement and anxiogenic behavior suggested subtle behavioral abnormalities. The identified chemicals likely originated from runoff or sewage and have potentially deleterious consequences for fish living in PBS or migrating to/from upstream spawning/nursery locations.

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“…In liver of Eurasian carp, hepatocyte necrosis was observed after waterborne exposure to lufenuron (0.1 mg/L) (Ghelichpour et al., 2019). Lufenuron exposure (0.1 mg/L) induced morphological changes in the gills and behavioural stress in tambaqui ( Colossoma macropomum ) (Soares et al., 2016). In liver of rats ( Rattus norvegicus ), lufenuron induces oxidative stress and acts genotoxic (Basal et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Lufenuron treatment temporarily represses gene expression and affects the SUMO pathway in liver of Atlantic salmon

Olsvik,

Brokke,

Samuelsen

et al. 2023

Journal of Fish Diseases

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Lufenuron is a benzoylurea insecticide currently in use to combat sea lice infestation in salmon aquaculture in Chile. With pending approval in Norway, the aim of this work was to study the uptake and toxicity of lufenuron in liver tissue of Atlantic salmon. Juvenile salmon weighing 40 g were given a standard 7‐day oral dose, and bioaccumulation and transcriptional responses in the liver were examined 1 day after the end‐of‐treatment (day 8) and after 1 week of elimination (day 14). Bioaccumulation levels of lufenuron were 29 ± 3 mg/kg at day 8 and 14 ± 1 mg/kg at day 14, indicating relatively rapid clearance. However, residues of lufenuron were still present in the liver after 513 days of depuration. The exposure gave a transient inhibition of transcription in the liver at day 8 (2437 significant DEGs, p‐adj < .05), followed by a weaker compensatory response at day 14 (169 significant DEGs). Pathways associated with RNA metabolism such as the sumoylation pathway were most strongly affected at day 8, while the apelin pathway was most profoundly affected at day 14. In conclusion, this study shows that lufenuron easily bioaccumulates and that a standard 7‐day oral dose induces a transient inhibition of transcription in liver of salmon.

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Acute and chronic toxicity of the benzoylurea pesticide, lufenuron, in the fish, Colossoma macropomum

Cited by 27 publications

References 33 publications

Retinal Toxicity Induced by Chemical Agents

Retinal Toxicity Induced by Chemical Agents

The Importance of Assessing Water Quality in Tributaries: A Case Study in an Urban Waterway Using Zebrafish (Danio rerio)

Lufenuron treatment temporarily represses gene expression and affects the SUMO pathway in liver of Atlantic salmon

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