Acute and chronic pain associated with Lyme borreliosis: Clinical characteristics and pathophysiologic mechanisms

Zimering, Jeffrey H.; Williams, Mark R.; Eiras, Maria E.; Fallon, Brian A.; Logigian, Eric L.; Dworkin, Robert H.

doi:10.1016/j.pain.2014.04.024

Cited by 19 publications

(13 citation statements)

References 37 publications

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“…Although there is very little data available on the association between addiction and LB, it is an area that deserves attention since chronic pain and psychiatric illness are seen with LB. Chronic pain from LB (headaches, neurological, musculoskeletal) occurred in 24% of United States confirmed and treated patients and the severity is comparable to post-surgical pain [ 117 , 118 ] Based upon a patient registry of 3900 patients 26% of Lyme patients are administered prescription pain medications compared to 16% of the age matched controls in the general US population [ 119 , 120 ]. The prevalence of chronic pain in suicidal LB patients is 65%, in suicidal and homicidal LB patients the prevalence is 57% and in LB patients who are not suicidal or homicidal the prevalence is 35% [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

Neuropsychiatric Lyme Borreliosis: An Overview with a Focus on a Specialty Psychiatrist’s Clinical Practice

Bransfield

2018

Healthcare

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There is increasing evidence and recognition that Lyme borreliosis (LB) causes mental symptoms. This article draws from databases, search engines and clinical experience to review current information on LB. LB causes immune and metabolic effects that result in a gradually developing spectrum of neuropsychiatric symptoms, usually presenting with significant comorbidity which may include developmental disorders, autism spectrum disorders, schizoaffective disorders, bipolar disorder, depression, anxiety disorders (panic disorder, social anxiety disorder, generalized anxiety disorder, posttraumatic stress disorder, intrusive symptoms), eating disorders, decreased libido, sleep disorders, addiction, opioid addiction, cognitive impairments, dementia, seizure disorders, suicide, violence, anhedonia, depersonalization, dissociative episodes, derealization and other impairments. Screening assessment followed by a thorough history, comprehensive psychiatric clinical exam, review of systems, mental status exam, neurological exam and physical exam relevant to the patient’s complaints and findings with clinical judgment, pattern recognition and knowledgeable interpretation of laboratory findings facilitates diagnosis. Psychotropics and antibiotics may help improve functioning and prevent further disease progression. Awareness of the association between LB and neuropsychiatric impairments and studies of their prevalence in neuropsychiatric conditions can improve understanding of the causes of mental illness and violence and result in more effective prevention, diagnosis and treatment.

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Section: Resultsmentioning

confidence: 99%

Neuropsychiatric Lyme Borreliosis: An Overview with a Focus on a Specialty Psychiatrist’s Clinical Practice

Bransfield

2018

Healthcare

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“…Persistent chronic pain in Lyme disease has been described in various studies as neuropathic or nociceptive (85). It has been noted in the literature that pain among patients with PTLD is uniquely asymmetrical, is more likely to involve the limbs, and is less widespread than in fibromyalgia (86,87), however to our knowledge these observations have not been systematically examined.…”

Section: Symptomsmentioning

confidence: 97%

Post-treatment Lyme Disease as a Model for Persistent Symptoms in Lyme Disease

2020

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“…However, inflammatory, musculoskeletal, neuropathic, and mixed conditions are suggested. [ 4 ] The persistent symptoms may be due to central sensitization, which is known as central sensitivity syndrome (CSS). [ 5 ] Many chronic pain states included under the category of CSS share the common features of augmented central nervous system pain and sensory processing systems (i.e., hyperalgesia and allodynia).…”

Section: Discussionmentioning

confidence: 99%

Exacerbation of chronic pain after dental extractions in a patient with post-treatment Lyme disease syndrome

Lim

Kinjo

2018

Saudi J Anaesth

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A subset of patients who had Lyme disease experience postinfectious signs or symptoms called post-treatment Lyme disease syndrome (PTLDS). PTLDS is a chronic condition including pain in joints and muscles, neurological symptoms including demyelinating diseases, peripheral neuropathy, headaches, sleep disturbances, fatigue, and cardiac conditions. We report a case of difficult acute pain management in a patient with PTLDS who underwent dental extractions and required admission to an intensive care unit for pain control.

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Acute and chronic pain associated with Lyme borreliosis: Clinical characteristics and pathophysiologic mechanisms

Cited by 19 publications

References 37 publications

Neuropsychiatric Lyme Borreliosis: An Overview with a Focus on a Specialty Psychiatrist’s Clinical Practice

Neuropsychiatric Lyme Borreliosis: An Overview with a Focus on a Specialty Psychiatrist’s Clinical Practice

Post-treatment Lyme Disease as a Model for Persistent Symptoms in Lyme Disease

Exacerbation of chronic pain after dental extractions in a patient with post-treatment Lyme disease syndrome

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