2020
DOI: 10.3389/fmed.2020.00057
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Post-treatment Lyme Disease as a Model for Persistent Symptoms in Lyme Disease

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Cited by 99 publications
(108 citation statements)
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References 187 publications
(273 reference statements)
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“…The most commonly observed symptoms of the patients in this study included back pain, dizziness, fatigue, muscle pain, and weakness in the extremities. This finding corresponds with those in other studies; fatigue, joint pain, difficulty in focusing, muscle pain, and memory were rated among the most common and/or severe [16,38,40,[45][46][47][48]. After calculating the change in number of patients with each symptom before and after treatment, it was found that the majority of symptoms improved in most of the symptom categories.…”
Section: Response To Treatment At the Body Systems Levelsupporting
confidence: 90%
See 1 more Smart Citation
“…The most commonly observed symptoms of the patients in this study included back pain, dizziness, fatigue, muscle pain, and weakness in the extremities. This finding corresponds with those in other studies; fatigue, joint pain, difficulty in focusing, muscle pain, and memory were rated among the most common and/or severe [16,38,40,[45][46][47][48]. After calculating the change in number of patients with each symptom before and after treatment, it was found that the majority of symptoms improved in most of the symptom categories.…”
Section: Response To Treatment At the Body Systems Levelsupporting
confidence: 90%
“…More research is needed on patient responses to treatment, both retrospective and prospective cohort studies, following both of the treatment guidelines designed to aid physicians in developing treatment regimens. The lack of this information has resulted in uncertainty for both patients and those treating them [47], a situation that needs to be resolved as the number of infections increases.…”
Section: Discussionmentioning
confidence: 99%
“…A conservative estimate of the prevalence of PTLDS in the United States in 2020 is 800,000 (51). The etiopathology of PTLDS is unknown, and the disease lacks suitable laboratory diagnostics and therapeutic methods (5). We aimed to address this ambiguity by investigating the microbiome, which has been shown to play an important role in diseases with symptom overlap with PTLDS.…”
Section: Discussionmentioning
confidence: 99%
“…and cognitive difficulties for more than 6 months after completion of antibiotic treatment (4)(5)(6)(7)(8). The etiopathology of PTLDS is unknown, but it presents with symptoms that overlap those of other diseases, including chronic fatigue syndrome (5,9), depression, fibromyalgia (5), and multiple sclerosis (10).…”
mentioning
confidence: 99%
“…Einzelne Autoren halten das Vorliegen einer chronischen Borreliose im Sinne einer persistierenden Infektion trotz einer regelgerecht durchgeführten antibiotischen Behandlung für möglich [37,38]. Für diese postulierten chronischen Infektionen werden teilweise morphologische Varianten von B. burgdorferi diskutiert, die den Erregern eine Persistenz trotz antibiotischer Behandlung erlauben [39].…”
Section: Chronische Verläufe Trotz Antibiotischer Behandlung Und Unspunclassified