Acute and chronic effects on rats of (?)?1-trans-tetrahydrocannabinol on unlearned motor tasks

R, Potvin; Fried, Peter A.

doi:10.1007/bf00421902

Cited by 29 publications

(2 citation statements)

References 11 publications

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“…Unlike Gonzalez et al, the latter authors suggested that the fear experience may actually be intensified under cannabinoids. Potvin and Fried (1972) have also suggested that chronic administration of THC in rats leads to hyperemotionality.…”

Section: Escape and Avoidance Behaviormentioning

confidence: 99%

Cannabis: Review of behavioral effects in animals.

Miller¹,

Drew²

1974

Psychological Bulletin

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Research studies concerning the action of cannabis and its .derivatives on numerous aspects of animal behavior including spontaneous activity, escape and avoidance behavior, schedule-controlled behavior, state-dependent learning, miscellaneous appetitively and nonappetitively motivated behavior, food and water intake, and aggression are reviewed. Disparate findings are discussed and attributed mainly to differences in dosage and experimental procedure. It is suggested that in a number of instances the effects of cannabis are similar to those of anticholinergic drugs. Guidelines for future research are suggested.

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Section: Escape and Avoidance Behaviormentioning

confidence: 99%

Cannabis: Review of behavioral effects in animals.

Miller¹,

Drew²

1974

Psychological Bulletin

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“…Lack o f suppression under cannabinoids has not been attributed to inter ference with consolidation; rather it has been suggested that cannabis reduces fear or anxiety associated with presentation o f the aversive stimulus (1, 59). Whether cannabis produces a true reduction in fear remains to be seen since some authors have hypothesized that cannabis and its derivatives produce hyperemotionality (74,124).…”

Section: Conditioned Fearmentioning

confidence: 99%

Cannabis: Neural Mechanisms and Behavior – a Theoretical Review

Drew¹,

Miller²

1974

Pharmacology

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The hypothesis is advanced that marihuana and espedaily Δ⁹-tetrahydrocannabinol, impair certain aspects of hippocampal neural functioning which are necessary for normal cognitive operations. It is suggested that many of the cognitive alterations induced by cannabinoids may be attributable to interference with cholinergic mechanisms. Both pharmacological and behavioral evidence are cited to support this hypothesis.

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