Cannabis: Neural Mechanisms and Behavior &amp;ndash; a Theoretical Review

Drew, William G.; Miller, Loren L.

doi:10.1159/000136463

Cited by 53 publications

(12 citation statements)

References 92 publications

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“…Although the adverse affects of marijuana on memory and cognitive function have long been ascribed to its actions in the hippocampus (Drew and Miller, 1974;Miller and Branconnier, 1983;Essman, 1984;Hampson and Deadwyler, 1998), the descrip-tion of CB binding sites in this brain region has provided strong corroborative evidence in favor of this hypothesis Howlett et al, 1990;Breivogel and Childers, 1998). Furthermore, the development of potent ligands for the CB1 receptor has provided a means to directly assess the effects of CBs in the CNS (Pertwee, 1997).…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Cannabinoid Inhibition of GABA_ASynaptic Transmission in the Hippocampus

2000

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The localization of cannabinoid (CB) receptors to GABAergic interneurons in the hippocampus indicates that CBs may modulate GABAergic function and thereby mediate some of the disruptive effects of marijuana on spatial memory and sensory processing. To investigate the possible mechanisms through which CB receptors may modulate GABAergic neurotransmission in the hippocampus, whole-cell voltage-clamp recordings were performed on CA1 pyramidal neurons in rat brain slices. Stimulus-evoked GABA(A) receptor-mediated IPSCs were reduced in a concentration-dependent manner by the CB receptor agonist WIN 55,212-2 (EC(50) of 138 nM). This effect was blocked by the CB1 receptor antagonist SR141716A (1 microM) but not by the opioid antagonist naloxone. In contrast, evoked GABA(B)-mediated IPSCs were insensitive to the CB agonist. WIN 55,212-2 also reduced the frequency of spontaneous, action potential-dependent IPSCs (sIPSCs), without altering action potential-independent miniature IPSCs (mIPSCs), measured while sodium channels were blocked by tetrodotoxin (TTX). Blockade of voltage-dependent calcium channels (VDCCs) by cadmium also eliminated the effect of WIN 55,212-2 on sIPSCs. Depolarization of inhibitory terminals with elevated extracellular potassium caused a large increase in the frequency of mIPSCs that was inhibited by both cadmium and WIN 55,212-2. The presynaptic effect of WIN 55,212-2 was also investigated using the potassium channel blockers barium and 4-aminopyridine. Neither of these agents significantly altered the effect of WIN 55,212-2 on evoked IPSCs. Together, these data suggest that presynaptic CB1 receptors reduce GABA(A)- but not GABA(B)-mediated synaptic inhibition of CA1 pyramidal neurons by inhibiting VDCCs located on inhibitory nerve terminals.

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Section: Discussionmentioning

confidence: 99%

Mechanisms of Cannabinoid Inhibition of GABA_ASynaptic Transmission in the Hippocampus

2000

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“…dry mouth and changes in heart rate. Experiments with animals have demonstrated (14,15,16) that cannabis decreases the release and turnover of acetylcholine in the hippocampus. Ashton (17) has argued directly that the hippocampus may be the final common path for cannabis and schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Cannabis and neuroleptic agents in schizophrenia

Knudsen

Vilmar

1984

Acta Psychiatr Scand

138

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A description is given of 10 schizophrenic patients whose condition was acutely aggravated following cannabis use, despite verified adequate depot treatment with neuroleptics. It is concluded that cannabis use constitutes a risk factor for schizophrenic patients, and the hypothesis is suggested that there may exist a cannabis-neuroleptics antagonistic interaction. Recent research in cannabis pharmacokinetics is presented in support of this hypothesis.

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“…Pharmacological manipulations which change the effects of cannabis to aggressiveness alter the dopamine/noradrenaline balance. Although evidence for an action on the dopaminergic system of cannabis has been presented, many of its effects (Masur & Khazam, 1970;Drew & Miller, 1974;Graham, Lewis & Li, 1974) cannot be explained solely by an interaction with dopamine. It seems likely that cannabis acts on different mechanisms which in turn interact with the transmitter systems discussed.…”

Section: Discussionmentioning

confidence: 99%

Cannabis, Catecholamines, Rapid Eye Movement Sleep and Aggressive Behaviour

Carlini

Lindsey

Tufik

1977

British J Pharmacology

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1Previous work from our laboratory has shown that cannabis induces aggressive behaviour in rats that have been deprived of rapid eye movement (REM) sleep. It was suggested that this effect was related to brain catecholamines, with dopamine playing an agonist role and noradrenaline an inhibitory one. The present paper describes new experiments dealing with this subject. 2 Previous REM sleep-deprivation enhanced both A9-tetrahydrocannabinol (THC)-induced hypothermia and nomifensine effects on aggressive behaviour. 3 A marihuana extract decreased brain dopamine turnover in REM sleep-deprived rats, an effect not observed in non-deprived rats. Noradrenaline metabolism was not altered. 4 Fighting behaviour was elicited in REM sleep-deprived rats treated with 4 different dopamine-,6-hydroxylase inhibitors. 5 Apomorphine, nomifensine and A9-THC administered to non-deprived rats pretreated with bis(4-methyl-l-homopiperanzinyl-thiocarbonyl) disulphide (Fla-63), induced fighting behaviour. 6 Nomifensine and apomorphine induced fighting in non-deprived rats pretreated with A9-THC. 7 Clonidine inhibited the fighting elicited in REM sleep-deprived rats by either A9-THC or 8 The data are discussed in terms of the influence of REM sleep-deprivation (or the stress associated with deprivation) on the response to dopaminergic drugs and cannabis. Taken together they emphasize the participation of brain dopamine and noradrenaline systems in the aggressive behaviour studied.

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Cannabis: Neural Mechanisms and Behavior – a Theoretical Review

Cited by 53 publications

References 92 publications

Mechanisms of Cannabinoid Inhibition of GABA_ASynaptic Transmission in the Hippocampus

Mechanisms of Cannabinoid Inhibition of GABA_ASynaptic Transmission in the Hippocampus

Cannabis and neuroleptic agents in schizophrenia

Cannabis, Catecholamines, Rapid Eye Movement Sleep and Aggressive Behaviour

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Cannabis: Neural Mechanisms and Behavior &ndash; a Theoretical Review

Cited by 53 publications

References 92 publications

Mechanisms of Cannabinoid Inhibition of GABAASynaptic Transmission in the Hippocampus

Mechanisms of Cannabinoid Inhibition of GABAASynaptic Transmission in the Hippocampus

Cannabis and neuroleptic agents in schizophrenia

Cannabis, Catecholamines, Rapid Eye Movement Sleep and Aggressive Behaviour

Contact Info

Product

Resources

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Cannabis: Neural Mechanisms and Behavior – a Theoretical Review

Mechanisms of Cannabinoid Inhibition of GABA_ASynaptic Transmission in the Hippocampus

Mechanisms of Cannabinoid Inhibition of GABA_ASynaptic Transmission in the Hippocampus