Acute and chronic effects of diazinon on the activities of three dehydrogenases in the digestive system of a freshwater teleost fish Channa punctatus

Sastry, K.V.; Malik, P.

doi:10.1016/0378-4274(82)90267-3

Cited by 15 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diazinon data from static tests are available for other fish species. Sastry and Malik (1982) conducted tests on Channa punctatus and found 96 hr LC50 of 11 uM. Cope (1965) determined 24 hr diazinon LC50 value of 0.19 pM and 1.38 pM respectively for bluegill and rainbow trout.…”

Section: Resultsmentioning

confidence: 99%

Comparative acute toxicities of selected pesticides to Anguilla anguilla

Ferrando

Sancho

Andreu-Moliner

1991

J. of Env. Sc. & Hlth., Part B

View full text Add to dashboard Cite

The acute toxicities (24, 48, 72 and 96 hr) of eight pesticides to Anguilla anguilla were determined. The organochlorine pesticide, endosulfan was the most toxic, with LC50 values in the range of 0.042 to 0.041 mg/L. Endosulfan was followed in order of decreasing toxicity by diazinon, fenitrothion, chlorpyrifos, lindane, methidathion, trichlorfon and methylparathion. When fishes were exposed to the pesticides tested they exhibited signs of restlessness, erratic swimming, convulsions and difficulty in respiration. This response was more persistent in fishes exposed to organophosphorus pesticides.

show abstract

Section: Resultsmentioning

confidence: 99%

Comparative acute toxicities of selected pesticides to Anguilla anguilla

Ferrando

Sancho

Andreu-Moliner

1991

J. of Env. Sc. & Hlth., Part B

View full text Add to dashboard Cite

show abstract

“…Pesticides destroy the endoplasmic reticulum, and this is accompanied by a decrease in G-6-pase activity. Sastry and Malik (1981) have reported inhibition of glucose-6-phosphatase (G-6-pase) in pesticide-intoxicated fish. Like the depletion of G-6-pase, the activity of fructose-1-6-diphosphatase (F-1-6-dipase) has also been found to be decreased.…”

Section: Discussionmentioning

confidence: 98%

Alteration of certain blood parameters of freshwater teleost Mystus vittatus after chronic exposure to Metasystox and Sevin

John

2006

Fish Physiol Biochem

103

View full text Add to dashboard Cite

Indiscriminate use of pesticides has elevated the risk of contamination of environment and aquatic habitat. Considering the above fact, the present study has been under taken to investigate the alteration of some blood parameters of freshwater teleost Mystus vittatus after chronic exposure to sublethal concentrations of Metasystox (4 ppm.) and Sevin (7 ppm.) individually. The main alterations observed in certain haematological parameters were clotting time (CT), erythrocyte sedimentation rate (ESR), haemoglobin percentage (Hb%), red blood corpuscles (RBCs), white blood corpuscles (WBCs), pack cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC). Alterations in organic constituents of blood, such as glucose, blood urea, total plasma protein and cholesterol, and in inorganic constituents, such as calcium, iron, magnesium, and phosphorus, were also studied. Alteration of enzymes such as glucose-6-phosphatase (G-6-pase), fructose-1-6-diphosphatase (F-1-6-dipase), serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were also studied, so that the changes in the blood biochemistry due to the pesticidal stress could be understood. Results indicated that CT, WBCs, MCH, MCHC, glucose, blood urea, cholesterol, magnesium and SGOT were increased, whereas other parameters were found to be decreased in both cases. Possible reasons for the above elevation are discussed in the light of available literature.

show abstract

“…Therefore, increases in ALP activity observed particularly in organisms exposed to diazinon, in addition to possible liver damage, may be associated with mechanisms of xenobiotics biotransformation. This contention is supported by the reported increase in ALP activity in snakeheads (Channa punctatus) exposed to diazinon (Sastry and Malik 1981), and in tilapia (Oreochromis niloticus) and trout (Oncorhynchus mykiss) exposed to pyrethroids (Firat et al 2011;Velisek et al 2009). Biotransformation enzymes of CYP1A phase I, and EROD activity in particular, are now regarded as some of the most sensitive and useful biomarkers in both laboratory and field for many fish species (Van der Oost et al 2003).…”

Section: Discussionmentioning

confidence: 76%

Physiological response of alligator gar juveniles (Atractosteus spatula) exposed to sub-lethal doses of pollutants

González

Cruz

Alfaro

2015

Fish Physiol Biochem

View full text Add to dashboard Cite

Alligator gar populations have declined because of overfishing, habitat loss and pollution. Over time, the exposure to different pollutants have affected these fishes as a consequence of their high trophic level, bottom-dwelling habits and long life span. In order to evaluate the physiological effects of pollutants on alligator gar, juveniles (6, 12 and 24 months) were exposed to sub-lethal doses of diazinon, β-naphthoflavone (BNF) and 17 β-estradiol (E2) by intraperitoneal injection. After 2 days of exposure, liver samples were taken to determine the activities of acetylcholinesterase, butyrylcholinesterase and carboxylesterase; alkaline and acid phosphatases (ALP and ACP); ethoxyresorufin o-deethylase (EROD); glutathione s-transferase (GST); superoxide dismutase (SOD), and vitellogenin (VTG) concentration. Two additional bioassays consisting on the exposure of compounds through water or food were performed and after 4 and 28 days, respectively, biomarkers were determined. All esterases were inhibited in organisms exposed to diazinon as well as in 6-months gar exposed to E2 and BNF. In contrast, ALP activity increased in gar exposed to diazinon and E2, while ACP activity did not show any variations. No EROD activity was registered after exposure to the different pollutants, despite being one of the most sensitive and common detoxification biomarkers used for fishes. GST activity reduction was detected when gar were exposed to E2 and BNF, while SOD activity increased after exposure to diazinon and E2. Finally, VTG levels were higher in animals exposed to E2 compared to other treatments. Overall, these results suggest that alligator gar juveniles have a low biotransformation metabolism and show that they are especially sensitive to those pollutants affecting the nervous system.

show abstract

Acute and chronic effects of diazinon on the activities of three dehydrogenases in the digestive system of a freshwater teleost fish Channa punctatus

Cited by 15 publications

References 10 publications

Comparative acute toxicities of selected pesticides to Anguilla anguilla

Comparative acute toxicities of selected pesticides to Anguilla anguilla

Alteration of certain blood parameters of freshwater teleost Mystus vittatus after chronic exposure to Metasystox and Sevin

Physiological response of alligator gar juveniles (Atractosteus spatula) exposed to sub-lethal doses of pollutants

Contact Info

Product

Resources

About