Acute and chronic animal models for the evaluation of anti-diabetic agents

Kumar, Suresh; Singh, Ramvir; Vasudeva, Neeru; Sharma, Swati

doi:10.1186/1475-2840-11-9

Cited by 94 publications

(92 citation statements)

References 81 publications

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“…1 The International Diabetes Federation have recently indicated that 8.3% of adults worldwide (387 million people) have diabetes and the same organization predicts that by 2035 this figure will rise to nearly 600 million people. 2 Observational evidence from experimental and clinical studies indicates that oxidative stress is involved in both the pathogenesis and the complications of DM.…”

Section: Introductionmentioning

confidence: 99%

Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats

Al‐Quraishy

Dkhil

Moneim

2015

IJN

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The study was designed to investigate the anti-hyperglycemic activity of selenium nanoparticles (SeNPs) in streptozotocin-induced diabetic rats. Fifty-five mg/kg of streptozotocin was injected in rats to induce diabetes. Animals either treated with SeNPs alone or with insulin (6 U/kg) showed significantly decreased fasting blood glucose levels after 28 days of treatment. The serum insulin concentration in untreated diabetic animals was also enhanced by SeNPs. The results demonstrated that SeNPs could significantly decrease hepatic and renal function markers, total lipid, total cholesterol, triglyceride and low-density lipoprotein cholesterol levels, and glucose-6-phosphatase activity. At the same time, SeNPs increased malic enzyme, hexokinase and glucose-6-phosphate dehydrogenase activity, liver and kidney glycogen contents, and high-density lipoprotein cholesterol levels. In addition, SeNPs were able to prevent the histological injury in the hepatic and renal tissues of rats. However, insulin injection also exhibited a significant improvement in diabetic animals after 28 days of treatment. This study suggests that SeNPs can alleviate hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats, possibly by eliciting insulin-mimetic activity.

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Section: Introductionmentioning

confidence: 99%

Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats

Al‐Quraishy

Dkhil

Moneim

2015

IJN

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“…Induced models have been created through five methods: surgical removal of the pancreas, administration of the drug alloxan, administration of the drug streptozotocin (STZ), highgalactose diets, and laser or chemical damage to the eye [27,[35][36][37][38][39][40][41][42][43][44][45][46]. While all methods of induction are still studied today, the most common is STZ administration, as it results in the fastest rate of disease development [41].…”

Section: Induced Modelsmentioning

confidence: 99%

“…Pancreatectomy was observed as early as 1922 to increase blood sugar levels in dogs [35], and by 1968-1971, a technique of complete pancreatectomy in adult dogs had been developed to induce diabetes [36,37]. This technically difficult method is usually applied to large animals such as cats and monkeys [27].…”

Section: Pancreatectomymentioning

confidence: 99%

“…Interestingly, while sex has not been found to impact susceptibility of type 1 or 2 [3], race [6][7][8][9] and socioeconomic status [8,10] do influence susceptibility for DR. In 2006, the MultiEthnic Study of Atherosclerosis (MESA) reported disparities in DR prevalence between diabetic patients of different racial backgrounds: 36.7% in African-Americans, 37.4% in Hispanics, 24.8% in Caucasians, and 25.7% in ChineseAmericans [8,9]. As a complex disease, it is clear that DR is strongly influenced by both genetics and environment [9, 11••, 12-17].…”

Section: Introductionmentioning

confidence: 99%

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Animal Models of Diabetic Retinopathy

Chen

Stitt

2015

Animal Models of Ophthalmic Diseases

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Purpose of Review Diabetic retinopathy (DR) is one of the most common complications associated with chronic hyperglycemia seen in patients with diabetes mellitus. While many facets of DR are still not fully understood, animal studies have contributed significantly to understanding the etiology and progression of human DR. This review provides a comprehensive discussion of the induced and genetic DR models in different species and the advantages and disadvantages of each model. Recent FindingsRodents are the most commonly used models, though dogs develop the most similar morphological retinal lesions as those seen in humans, and pigs and zebrafish have similar vasculature and retinal structures to humans. Nonhuman primates can also develop diabetes mellitus spontaneously or have focal lesions induced to simulate retinal neovascular disease observed in individuals with DR. Summary DR results in vascular changes and dysfunction of the neural, glial, and pancreatic β cells. Currently, no model completely recapitulates the full pathophysiology of neuronal and vascular changes that occur at each stage of diabetic retinopathy; however, each model recapitulates many of the disease phenotypes.

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“…Screening of new drug requires an appropriate animal model and other environmental condition for treatment of diabetes. 8 The major objective of the present review is to bring collectively all different in vivo models and in vitro methods under one plane so that it may be useful to researchers who are seeking their experimental work on diabetes.…”

mentioning

confidence: 99%

Past and Future of in-vitro and in-vivo Animal Models for Diabetes: A Review

Dewangan¹,

Tiwari²,

Sharma³

et al. 2017

IJPER

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Diabetes mellitus is classified into two major types, Type 1 (Insulin Dependent Diabetes Mellitus) and Type 2 (Non-Insulin Dependent Diabetes Mellitus). In world about 90% of diabetes patients are of Type 2 diabetes. There are various in-vivo and in-vitro methods available for the screening of new antidiabetic drugs. In-vivo models mainly uses chemical such as streptozotocin, alloxan etc. for the induction of diabetes where as in-vitro techniques, directly show its effect on cells which are responsible for induction of diabetes in human. In vitro techniques provide more accurate data and possible mechanism which are involved in diabetes disease. Now, a day's newer techniques such as diabetes induction with the help of viruses had been also introduced which are proving to be good tool in evaluation of antidiabetic drugs. This review could prove to be a good tool for the researchers who seek to do research on diabetes as it is providing vast resource about diabetic model under single umbrella.

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Acute and chronic animal models for the evaluation of anti-diabetic agents

Cited by 94 publications

References 81 publications

Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats

Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats

Animal Models of Diabetic Retinopathy

Past and Future of in-vitro and in-vivo Animal Models for Diabetes: A Review

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