Acute Alcohol Intoxication in a Two-Month-Old Baby

Yamagishi, Minoru; Iwasaki, Tetsumi

doi:10.7888/juoeh.9.53

Cited by 4 publications

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“…13 Moreover, an epidemiologic study 14 found no significant difference in the motor and mental development of 1-year-old breastfed infants whose mothers drank less than one drink per day, compared with either breastfed infants whose mothers did not drink at all or those who were formula-fed. Only those infants who were exposed regularly (at least daily) to alcohol in their mothers' breast milk, showed a slight, but significant deficit in gross motor, but not mental, development.…”

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confidence: 97%

“…6,7 Because alcohol is excreted to a limited extent in breast milk, 5,8,9 occasional exposure often is considered insignificant, 8,10 except in such rare cases of intoxication when the mothers of breastfeeding infants drank quite heavily 11,12 or when infants were inadvertently fed large amounts of alcohol in a bottle. 13 Moreover, an epidemiologic study 14 found no significant difference in the motor and mental development of 1-year-old breastfed infants whose mothers drank less than one drink per day, compared with either breastfed infants whose mothers did not drink at all or those who were formula-fed. Only those infants who were exposed regularly (at least daily) to alcohol in their mothers' breast milk, showed a slight, but significant deficit in gross motor, but not mental, development.…”

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confidence: 98%

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Effects of Exposure to Alcohol in Mother's Milk on Infant Sleep

Mennella

Gerrish

1998

Pediatrics

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ABSTRACT.Objective. To test the hypothesis that exposure to alcohol in breast milk affects infants' sleep and activity levels in the short term.Methods. Thirteen lactating women and their infants were tested on 2 days, separated by an interval of 1 week. On each testing day, the mother expressed 100 mL of milk, while a small, computerized movement detector called an actigraph was placed on the infant's left leg to monitor sleep and activity patterning. After the actigraph had been in place for ϳ15 minutes, the infants ingested their mother's breast milk flavored with alcohol (32 mg) on one testing day and breast milk alone on the other. The infants' behaviors were monitored for the next 3.5 hours.Results. The infants spent significantly less time sleeping during the 3.5 hours after consuming the alcohol-flavored milk (78.2 minutes compared with 56.8 minutes after feeding alcohol in breast milk). This reduction was apparently attributable to a shortening in the longest sleeping bout (34.5 compared with 56.7 minutes for sleeping after breast milk alone) and the amount of time spent in active sleep (25.8 minutes compared with 44.2 minutes after breast milk alone); the decrease in active sleep was observed in all but 2 of the 13 infants tested.Conclusions. Although the mechanisms underlying the reduction in sleep remain to be elucidated, this study shows that short-term exposure to small amounts of alcohol in breast milk produces distinctive changes in the infant's sleep-wake patterning. Pediatrics 1998;101(5). URL: http://www.pediatrics.org/cgi/content/full/101/5/e2; alcohol, lactation, sleep, activity, development, infant behavior. ABBREVIATION. NS, not significant. T he notion that infants can be influenced by components in their mothers' breast milk has a rich, long history.1 Physicians in the 18th century often would treat the infants' ailments by prescribing certain diets to the mother or wet nurse. 2 That such practices continue in more modern times is evident in the medical lore that recommends that nursing mothers drink an occasional alcoholic beverage, preferably before the evening feeding, to alleviate and sedate their fussy infants. 3,4 No experimental evidence supports this recommendation, although a previous study on the effects of maternal alcohol consumption on the feeding behaviors of breastfed infants reported that the infants' patterning of sleeping, as determined from logs completed by mothers, indeed was altered in the short term. 5Despite this lore, the question of whether occasional exposure to alcohol in breast milk can affect the infant continues to generate much speculation in the medical community.6,7 Because alcohol is excreted to a limited extent in breast milk, 5,8,9 occasional exposure often is considered insignificant, 8,10 except in such rare cases of intoxication when the mothers of breastfeeding infants drank quite heavily 11,12 or when infants were inadvertently fed large amounts of alcohol in a bottle. 13 Moreover, an epidemiologic study 14 found no significant difference in the ...

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confidence: 97%

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confidence: 98%

Effects of Exposure to Alcohol in Mother's Milk on Infant Sleep

Mennella

Gerrish

1998

Pediatrics

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“…12 Others have argued that a neonate might have conditions such as lactic acidosis and/or diabetic ketoacidosis, probably due to ethanol and its oxidation under hypoxic conditions, and additional glucose contained in alcoholic beverages, which lead to hyperglycemia rather than hypoglycemia. 5 The skin over the entire body of this patient was flushed except for pale extremities. The flushed skin caused by alcohol is a complex phenomenon by several mechanisms, such as opiate peptides, prostaglandins, histamines, kinins and catecholamines, which are associated with vasodilatation activated by acetaldehyde.…”

Section: Discussionmentioning

confidence: 85%

“…demonstrated that catalase might play a more prominent role in the metabolism of alcohols than alcohol dehydrogenase (ADH) in perinatal infants . Others have argued that a neonate might have conditions such as lactic acidosis and/or diabetic ketoacidosis, probably due to ethanol and its oxidation under hypoxic conditions, and additional glucose contained in alcoholic beverages, which lead to hyperglycemia rather than hypoglycemia …”

Section: Discussionmentioning

confidence: 99%

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Acute alcohol intoxication in a 15‐day‐old neonate

Zaitsu

Inada

Tashiro

et al. 2013

Pediatrics International

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We describe a 15-day-old newborn girl who was fed with formula milk that was accidentally diluted with sake (Japanese wine prepared from fermented rice). The clinical features were flushed skin, tachycardia and low blood pressure indicating circulatory failure, somnolence and metabolic acidosis without hypoglycemia. The serum ethanol concentration was 43.0 mg/dL at 3 h after intake. The patient recovered under intravenous fluid replacement without complications. Follow-up examinations at 1, 2, 3, 6 and 12 months confirmed normal psychomotor development.

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Alcohol Use during Lactation

Mennella¹

2003

Nutrition and Alcohol

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Acute Alcohol Intoxication in a Two-Month-Old Baby

Cited by 4 publications

References 1 publication

Effects of Exposure to Alcohol in Mother's Milk on Infant Sleep

Effects of Exposure to Alcohol in Mother's Milk on Infant Sleep

Acute alcohol intoxication in a 15‐day‐old neonate

Alcohol Use during Lactation

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