Acute abdominal pain following fracture of a heterotopically formed bone incorporating a prolene mesh

Nageswaran, H.; Dunkley, A. B.

doi:10.1308/147870810x12699662980871

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…Beside non-genetic factors like mechanical stress, nutrition, glucose intolerance, and high body mass index, recent studies showed numerous genes are associated with the disease. Most of these genes are vital to the ossification process like NPPS, COL11A2, COL6A1, BMP2, BMP4, TGF-β1, TGF-β3 4 5 6 7 22 24 , and often aberrant expression of these genes can cause the pathological heterogeneous ossification 25 26 . This means a certain disorder in the upstream regulatory network of these critical factors may exists during the pathological process of OPLL.…”

Section: Discussionmentioning

confidence: 99%

Integrated microRNA-mRNA analyses reveal OPLL specific microRNA regulatory network using high-throughput sequencing

Chen

Zhang

et al. 2016

Sci Rep

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Ossification of the posterior longitudinal ligament (OPLL) is a genetic disorder which involves pathological heterotopic ossification of the spinal ligaments. Although studies have identified several genes that correlated with OPLL, the underlying regulation network is far from clear. Through small RNA sequencing, we compared the microRNA expressions of primary posterior longitudinal ligament cells form OPLL patients with normal patients (PLL) and identified 218 dysregulated miRNAs (FDR < 0.01). Furthermore, assessing the miRNA profiling data of multiple cell types, we found these dysregulated miRNAs were mostly OPLL specific. In order to decipher the regulation network of these OPLL specific miRNAs, we integrated mRNA expression profiling data with miRNA sequencing data. Through computational approaches, we showed the pivotal roles of these OPLL specific miRNAs in heterotopic ossification of longitudinal ligament by discovering highly correlated miRNA/mRNA pairs that associated with skeletal system development, collagen fibril organization, and extracellular matrix organization. The results of which provide strong evidence that the miRNA regulatory networks we established may indeed play vital roles in OPLL onset and progression. To date, this is the first systematic analysis of the micronome in OPLL, and thus may provide valuable resources in finding novel treatment and diagnostic targets of OPLL.

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Section: Discussionmentioning

confidence: 99%

Integrated microRNA-mRNA analyses reveal OPLL specific microRNA regulatory network using high-throughput sequencing

Chen

Zhang

et al. 2016

Sci Rep

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“…HMO is a rare subtype of HO occurring in the mesentery. The exact incidence and prevalence rates for HMO are unclear because many cases are believed to be asymptomatic and underdiagnosed [ 16 ]. It is believed to be relatively rare because only fewer than 100 cases have been reported so far in the English-language literature [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Heterotopic Mesenteric Ossification With Trilineage Hematopoiesis

Martinbianco¹,

Lilley²,

Grech³

et al. 2022

Cureus

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Heterotopic ossification (HO) histologically refers to extraskeletal bone formation in non-ossifying tissues, most commonly noted in the extremities, buttocks, abdominal wall, and hip joints. HO developing in the mesentery (heterotopic mesenteric ossification, HMO) is very rare, with fewer than 100 cases reported in the literature. It usually occurs in adult male patients with a history of repeated abdominal trauma. So far, only two cases of HMO have been reported with the development of hematopoietic bone marrow. Here, we report the third case of HMO with true trilineage hematopoiesis in a 66-year-old female with suspicious mesenteric-retained foreign material from prior surgical procedures, including hysterectomy for endometrial adenocarcinoma and multiple repairs for incisional hernia.

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“…To our knowledge, there has been only one similar case report. Nagesawaran7 reported a patient with acute abdominal pain secondary to fracture of heterotopic bone enveloping 17-year-old prolene mesh. The bone had a periosteal layer, nutrient artery and histologically confirmed lamellar bone and bone marrow.…”

Section: Discussionmentioning

confidence: 99%

Total heterotopic ossification of an acellular dermal matrix used for abdominal wall reconstruction

2013

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Heterotopic ossification is an observable phenomenon in the setting of abdominal wounds, estimated to effect 25% of all patients after midline abdominal surgery. The development of acellular dermal matrices has revolutionised the approach in repairing abdominal hernias, especially for potentially contaminated wounds. We describe a case of heterotopic bone formation incorporating the whole of an acellular dermal matrix in a patient on chronic steroid therapy.

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Acute abdominal pain following fracture of a heterotopically formed bone incorporating a prolene mesh

Cited by 5 publications

References 4 publications

Integrated microRNA-mRNA analyses reveal OPLL specific microRNA regulatory network using high-throughput sequencing

Integrated microRNA-mRNA analyses reveal OPLL specific microRNA regulatory network using high-throughput sequencing

Heterotopic Mesenteric Ossification With Trilineage Hematopoiesis

Total heterotopic ossification of an acellular dermal matrix used for abdominal wall reconstruction

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