Acupuncture Stimulation of ST36 (Zusanli) Attenuates Acute Renal but Not Hepatic Injury in Lipopolysaccharide-Stimulated Rats

Huang, Chin Liang; Tsai, Pei Shan; Wang, Tao Yeuan; Li, Yan; Xu, Haiyan; Huang, Chun Jen

doi:10.1213/01.ane.0000255288.68199.eb

Cited by 38 publications

(42 citation statements)

References 24 publications

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“…27,28 Animal studies have also indicated that acupuncture pretreatment has protective effects against endotoxin-induced acute lung and kidney injuries. 29,30 However, little is known about its biologic basis.…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture Improves Survival in Rats with Lethal Endotoxemia via the Autonomic Nervous System

Song¹,

Cao

et al. 2012

Anesthesiology

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Background: Recent advances have indicated a complex interplay between the autonomic nervous system and the innate immune system. Targeting neural networks for the treatment of sepsis is being developed as a therapeutic strategy. Because electroacupuncture at select acupoints can modulate activities of the autonomic nervous system, we tested the hypothesis that electroacupuncture at specific acupoints could modulate systemic inflammatory responses and improve survival via its impact on the autonomic nervous system in a rat model of sepsis. Methods: Sprague-Dawley male rats received electroacupuncture for 45 min before and at 1, 2, or 4 h after a lethal dose of intraperitoneal lipopolysaccharide injection (6 mg/ kg). Outcomes included survival and systemic cytokine re-

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Section: Discussionmentioning

confidence: 99%

Electroacupuncture Improves Survival in Rats with Lethal Endotoxemia via the Autonomic Nervous System

Song¹,

Cao

et al. 2012

Anesthesiology

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“…After chronic treatment, liver microsomal lipid peroxidation value decreased significantly. Moreover, given that the manual stimulation of the acupoint ST-36 is able to attenuate renal injury induced by sepsis 10 , it is possible that electrical stimulation of that acupoint can alter the concentrations of MDA, an indicator of cell membrane injury, in renal tissue.…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture attenuates liver and kidney oxidative stress in anesthetized rats

Silva¹,

Figueiredo²,

Dias³

et al. 2011

Acta Cir. Bras.

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PURPOSE:Investigate the effects of a single electroacupuncture (EA) session at acupoints Zusanli (ST-36) and Zhongwan (CV-12) combined in regulating oxidative stress in liver and kidney in anesthetized rats. METHODS: Eighteen healthy rats randomly assigned to 3 groups (n=6) were anesthetized intraperitoneally with ketamine (90mg kg -1 body weight) + xylazine (10mg/kg body weight): G-1: Control (anesthesia), G-2: anesthesia+EA10Hz and 10 mA, 10 Hz) applied to right ST-36 and CV-12 acupoints for 30 minutes. G-3 was likewise treated, using a tenfold higher frequency (100 Hz). G6PDH activity, malondialdehyde (MDA) and glutathione (GSH) levels were assayed spectrophotometrically. RESULTS: Liver MDA and GSH concentrations increased significantly in rats submitted to EA 10Hz (p<0.01) and EA 100Hz (p<0.001), compared with control G-1. Liver and kidney G6GPH activity decreased significantly in G-2 (p<0.01) and G-3 (p<0.001) compared with G-1 in EA100Hz rats. A similar pattern was found in kidney G6PDH activity in EA10Hz rats. CONCLUSION: Single 30-minute EA 10/100Hz session enhances lipid peroxidation and simultaneously reduces oxidative stress in liver and kidney tissues in a rat model. Keywords: Acupuncture. Electroacupuncture. Lipid Peroxidation. Oxidative Stress. Rats. RESUMO OBJETIVO: Investigar os efeitos de uma única sessão de eletroacupuntura (EA) aplicada nos acupontos Zusanli (E-36) e Zhongwan (RM-12) simultaneamente, na regulação do estresse oxidativo no fígado e rins em ratos anestesiados. MÉTODOS: Dezoito ratos sadios, distribuídos aleatoriamente em três grupos (n = 6), foram anestesiados com cetamina (90mg/kg de peso) + xilazina (10mg/kg de peso): G-1: Controle (anestesia), G-2: anestesia + EA10Hz e G-3: anestesia + EA100Hz. Os ratos do grupo G-2 foram submetidos à EA (ondas quadradas pulsadas, 10 mA, 10 Hz) aplicada aos acupontos ST-36 direito e VC-12 por 30 minutos. Nos ratos do grupo G-3 utilizou-se uma freqüência dez vezes maior (100 Hz). A atividade da enzima G6PDH e as concentrações de malondialdeído (MDA) e glutationa (GSH) foram verificadas por espectrofotometria. RESULTADOS: As concentrações hepáticas de MDA e GSH aumentaram significativamente nos ratos submetidos à EA, utilizando 10Hz (p <0,01) e 100Hz (p <0,001), comparado com o controle. A atividade de G6GPH diminuiu significativamente no G-2 (p <0,01) e G-3 (p <0,001) no fígado e no rim em comparação ao grupo G-1 em ratos tratados com 100Hz. CONCLUSÃO: Uma única sessão de EA 10/100Hz por 30 minutos aumenta a peroxidação lipídica e simultaneamente reduz o estresse oxidativo no fígado e no rim de ratos sadios. Descritores: Acupuntura. Eletroacupuntura. Peroxidação de Lipídeos. Estresse Oxidativo. Ratos. Electroacupuncture attenuates liver and kidney oxidative stress in anesthetized rats

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“…EA is an electrical stimulation through the acupuncture needles with short current pulse at different frequencies [11] . Both EA [10,[21][22][23][24] and MO [25] have been shown to influence renal function, although little is currently understood about their role [26] .…”

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confidence: 99%

Electroacupuncture and Moxibustion Attenuate the Progression of Renal Disease in 5/6 Nephrectomized Rats

Paterno

Freire

Soares³

et al. 2008

Kidney Blood Press Res

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Background/Aim: Chronic kidney disease is a worldwide public health problem and the prevention of its progression is still a major challenge in nephrology. Specific therapies that inhibit or attenuate this process are neither available nor satisfactory. Traditional Chinese medicine has been increasingly recognized as an effective therapeutic approach in several fields of medicine. The aim of this study was to investigate the effects of electroacupuncture (EA) and moxibustion (MO) in an experimental model of progressive renal disease in rats. Methods: Twenty-one male Wistar rats were submitted to 5/6th nephrectomy (NX) and assessed 8 weeks later and were divided into three groups: NX = only 5/6 NX, NX-AS = 5/6 NX and a 20-min EA-MO session in sham points, and NX-AM = 5/6 NX and a 20-min EA-MO session in three real acupuncture points. The treatment consisted of 16 sessions twice a week. Renal function, urine volume, serum creatinine, 24-hour proteinuria, direct and indirect blood pressure, glomerulosclerosis and tubulointerstitial fibrosis indices were assessed. Results: The NX-AM group showed a significant decrease in all investigated parameters when compared to the control groups. Conclusion: Our results suggest that EA and MO attenuated the progression of renal disease in the experimental model of 5/6 NX.

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Acupuncture Stimulation of ST36 (Zusanli) Attenuates Acute Renal but Not Hepatic Injury in Lipopolysaccharide-Stimulated Rats

Abstract: ST36 acupuncture pretreatment significantly attenuated sepsis-induced kidney, but not liver, injury in rats, whereas ST36 acupuncture performed after sepsis induction had no protective effects against sepsis-induced organ injuries.

Cited by 38 publications

References 24 publications

Electroacupuncture Improves Survival in Rats with Lethal Endotoxemia via the Autonomic Nervous System

Electroacupuncture Improves Survival in Rats with Lethal Endotoxemia via the Autonomic Nervous System

Electroacupuncture attenuates liver and kidney oxidative stress in anesthetized rats

Electroacupuncture and Moxibustion Attenuate the Progression of Renal Disease in 5/6 Nephrectomized Rats

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