Acupuncture increases cell proliferation in dentate gyrus after transient global ischemia in gerbils

Comparing the Effects of Acupuncture and Electroacupuncture at Zusanli and Baihui on Cell Proliferation and Neuroblast Differentiation in the Rat Hippocampus

“…In addition, EA at GV20 and An-Mian (EX17) increased hippocampal progenitor cell proliferation in adult rats exposed to chronic unpredictable stress [20]. In ischemic models [17] and streptozotocin-induced diabetic models [16], acupuncture at ST36 increased cell proliferation in the DG. In a spontaneous recurrent seizure model, EA at ST36 significantly reduced the number of spontaneous recurrent seizures and significantly elevated the expression of GAD67 mRNA in the DG [9].…”

“…Acupuncture (ACU) is an ancient Chinese treatment for illness, pain, or even metabolic and pathological brain disease [16,17] that uses fine needles in defined points of the body. In addition, ACU or electroacupuncture (EA) facilitates the release of neuropeptides, modulating gene expression in neuronal cells in the central nervous system (CNS), eliciting profound physiological effects, and activating selfhealing mechanisms [11,13,17].…”

“…In addition, ACU or electroacupuncture (EA) facilitates the release of neuropeptides, modulating gene expression in neuronal cells in the central nervous system (CNS), eliciting profound physiological effects, and activating selfhealing mechanisms [11,13,17]. Similarly, ACU and EA have shown positive effects in the treatment of mental disorders, such as major depression [10,18].…”

Effects of Puerariae radix on Cell Proliferation and Nitric Oxide Synthase Expression in Dentate Gyrus of Alcohol-Intoxicated Sprague-Dawley Rats

“…It has been demonstrated that the process of neurogenesis, the birth of new neurons, occurs in the hippocampal dentate gyrus in a variety of mammals, including humans (5,6). Several factors, including glucocorticoids, estrogen, Nmethyl-D-aspartate receptor, serotonin, ischemia, seizures and environmental stimuli are known to influence the proliferation of granule cell precursors in the adult dentate gyrus (5 -7).…”

“…For detection of newly generated cells in the dentate gyrus, the associated BrdU incorporation was visualized via a previously described immunohistochemical method (5,6). First, ten sections on average were collected from each brain within the dorsal hippocampal region spanning from Bregma -3.30 mm to -4.16 mm.…”