Acupuncture Attenuated Vascular Dementia–Induced Hippocampal Long-Term Potentiation Impairments via Activation of D1/D5 Receptors

Ye, Yang; Li, Hui; Yang, Jing‐Wen; Wang, Xuerui; Shi, Guang‐Xia; Yan, Chao-Qun; Ma, Si‐Ming; Zhu, Wenxu; Li, Qianqian; Li, Tianran; Xiao, Ling-Yong; Liu, Cun‐Zhi

doi:10.1161/strokeaha.116.014696

Cited by 54 publications

(76 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We demonstrated that patients with stroke had signi cantly higher incidence of dementia rates within 3year follow-up, and the incidence of dementia in male patients with stroke was higher than that of female patients with stroke. A pooled analysis of international data classi ed important contributors and risk factors to post-stroke dementia, and age over 65 and female gender are the mentioned risk factors [26,27]. The mean age in our study and the result that stroke patients had higher incidence of dementia match with this analysis, however the effect of gender did not.…”

Section: Discussionsupporting

confidence: 68%

Acupuncture Decreases the Incidence of Post-stroke Dementia: A Taiwan Nationwide Retrospective Cohort Study

Chu

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

BACKGROUND Stroke has been recognized as one of the major causes of adult disability worldwide, and post-stroke dementia may affect up to one-third of stroke survivors. This condition could be prevented if we could recognize and treat it earlier. Acupuncture as a complementary treatment for stroke has been shown to be beneficial for subsequent post-stroke rehabilitation. Our study investigated if acupuncture served additional advantages to decreasing the incidence of post-stroke dementia. METHODS We provide a retrospective cohort study from Taiwan National Health Insurance Research Database. This study compared the incidence of post-stroke dementia between cohorts with and without acupuncture treatment by calculating adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of acupuncture associated with post-stroke dementia using Cox proportional hazard regressions. The study group was composed of 9,547 patients who received first hospitalization for the treatment of stroke between 2002 and 2004; of which, 47,735 comparison patients were defined as the control group. The two groups were followed-up until the diagnosis of dementia presented or until the end of 2007. RESULTS The adjusted HRs of developing dementia among patients with stroke was 4.705 times the average (range, 4.353–5.085), and the incidence of dementia was higher in males. The study group tended to have less incidence of all kinds of dementia after acupuncture treatment, and patients without stroke receiving acupuncture had a lower probability of dementia than those untreated during the follow-up period. CONCLUSIONS This study presents evidence that acupuncture serves as an effective and alternative procedure to lower the risk of post-stroke dementia and the overall incidence of dementia in Taiwanese population.

show abstract

Section: Discussionsupporting

confidence: 68%

Acupuncture Decreases the Incidence of Post-stroke Dementia: A Taiwan Nationwide Retrospective Cohort Study

Chu

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…To assess spatial learning and memory, rats were trained and tested in MWM after acupuncture as described before . In brief, each rat was trained 3 times per day for 5 consecutive days.…”

Section: Methodsmentioning

confidence: 99%

“…Rats were fixed with a stereotaxic frame (SR‐6 N; Narishige, Japan) after anesthetized with urethane (1.2 g/kg, IP). Electrodes were positioned as our previous study . The lateral prepenetrating (PP) was stimulated during the long‐term potentiation (LTP) experiments.…”

Section: Methodsmentioning

confidence: 99%

Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study

et al. 2018

Self Cite

View full text Add to dashboard Cite

Aims: Acupuncture has been reported to affect vascular dementia through a variety of molecular mechanisms. An isobaric tag for relative and absolute quantification (iTRAQ) with high-resolution liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyses makes it possible to attain a global profile of proteins. Hence, we used an iTRAQ-LC-MS/MS strategy to unravel the underlying mechanism of acupuncture.Methods: Wistar rats were subjected to vascular dementia with bilateral common carotid occlusion. Acupuncture was intervened for 2 weeks at 3 days after surgery.The Morris water maze was used to assess the cognitive function. Proteins were screened by quantitative proteomics and analyzed by bioinformatic analysis. Four differentially expressed proteins (DEPs) were validated by western blot. The reactive oxygen species (ROS) production, neuron cell loss, and long-term potentiation (LTP) were determined after western blot.Results: Acupuncture at proper acupoints significantly improved cognitive function.A total of 31 proteins were considered DEPs. Gene ontology (GO) analysis showed that most of the DEPs were related to oxidative stress, apoptosis, and synaptic function, which were regarded as the major cellular processes related to acupuncture effect. Western blot results confirm the credibility of iTRAQ results. Acupuncture could decrease ROS production, increase neural cell survival, and improve LTP, which verified the three major cellular processes. Conclusion: Acupuncture may serve as a promising clinical candidate for the treatment of vascular dementia via regulating oxidative stress, apoptosis, or synaptic functions. K E Y W O R D S acupuncture, iTRAQ, proteomics, vascular dementia 1 | INTRODUC TI ON Vascular dementia (VaD) as the second most common cognitive disorders, following Alzheimer's disease (AD), is caused by a series of cardiac-cerebral vascular conditions that are characterized by loss of cognitive functions. 1,2 The worldwide number of patients with VaD is estimated to rise because no effective prevention or treatment strategy is available. 3 Progress toward finding effective treatments for VaD S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Yang J-W, Wang X-R, Zhang M, et al. Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study. CNS

show abstract

“…As a peripheral stimulation, acupuncture could improve the performance of dementia rodents in MWM by elevating the CBF velocity and volume of prefrontal lobe and hippocampus [32,33]. In this study, GV20 and ST36 were selected based on our published results as an ideal combination of acupoints that is benefit on memory deficits in BCCAO-induced VaD rats [34,35]. Consistent with previous studies, we found that BCCAO rats with increased escape latency and decreased time in target quadrant in probe trial showed declined white matter CBF.…”

Section: Discussionmentioning

confidence: 99%

“…VaD model was induced by BCCAO method as preciously described [28]. Rats were anesthetized with intraperitoneal injection of sodium pentobarbital (40 mg/kg body weight).…”

Section: Surgical Proceduresmentioning

confidence: 99%

Acupuncture improves white matter perfusion and white matter integrity in vascular dementia rats: an MRI-based imaging study

Ma¹,

Wang²,

Su³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: White matter lesions induced by chronic cerebral hypoperfusion (CCH) are common pathological changes, and are associated with cognitive impairment in vascular dementia (VaD). It has been reported that acupuncture can improve cognitive deficits of VaD rats through increasing cortical cerebral blood flow and attenuating neuroinflammation. However, the effects of acupuncture on white matter perfusion and white matter structural integrity have been not investigated. Methods: VaD was induced by bilateral common carotid arteries occlusion (BCCAO)in Wistar rats. Morris water maze (MWM) was used to evaluated the spatial learning and memory of rats. Arterial spin labeling imaging (ASL) and diffusion tensor imaging (DTI) were performed to measure the cerebral blood flow and white matter integrity in corpus callosum, external capsule, internal capsule, optic nerve and optic tract. Pathological staining was also applied to detect the myelin loss and neuroinflammation.Results: BCCAO rats with declined cerebral blood flow exhibited significant worse MWM performance, and altered DTI parameters including decreased fractional anisotropy, elevated radial diffusivity and axial diffusivity in white matter regions.After acupuncture treatment at GV20 and ST36, cognitive dysfunction, disruption of white matter perfusion and integrity were reversed. Pathological results supported that acupuncture could attenuate the loss of myelin sheath and microglia activation. Conclusions:Our findings suggest that acupuncture treatment protects cognitive impairment of BCCAO rats through increasing subcortical white matter perfusion and improving white matter lesions.

show abstract

Acupuncture Attenuated Vascular Dementia–Induced Hippocampal Long-Term Potentiation Impairments via Activation of D1/D5 Receptors

Abstract: Improvement in cognition and hippocampal synaptic plasticity induced by acupuncture was achieved via activation of D1/D5 receptors in 2VO rats.

Cited by 54 publications

References 41 publications

Acupuncture Decreases the Incidence of Post-stroke Dementia: A Taiwan Nationwide Retrospective Cohort Study

Acupuncture Decreases the Incidence of Post-stroke Dementia: A Taiwan Nationwide Retrospective Cohort Study

Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study

Acupuncture improves white matter perfusion and white matter integrity in vascular dementia rats: an MRI-based imaging study

Contact Info

Product

Resources

About