Acupuncture ameliorated skeletal muscle atrophy induced by hindlimb suspension in mice

Onda, Akiko; Jiao, Qibin; Nagano, Yuichiro; Akimoto, Takayuki; Miyamoto, Terumasa; Minamisawa, Susumu; Fukubayashi, Toru

doi:10.1016/j.bbrc.2011.05.152

Cited by 38 publications

(64 citation statements)

References 42 publications

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“…[13][14][15] Acupuncture has been shown to decrease skeletal muscle atrophy induced by hind-limb suspension in mice. 16 Electrical acupuncture treatment has been shown to suppress myostatin expression, which leads to a satellite cell-related proliferative reaction and repair in skeletal muscle. 17 Low-frequency electrical stimulation (LFES) is an acupuncture technique that replicates the benefits of resistance exercise through stimulation of muscle contraction.…”

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confidence: 99%

Low-Frequency Electrical Stimulation Attenuates Muscle Atrophy in CKD—A Potential Treatment Strategy

Klein

Hassounah

et al. 2015

Journal of the American Society of Nephrology

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Effective therapeutic strategies to treat CKD-induced muscle atrophy are urgently needed. Lowfrequency electrical stimulation (LFES) may be effective in preventing muscle atrophy, because LFES is an acupuncture technique that mimics resistance exercise by inducing muscle contraction. To test this hypothesis, we treated 5/6-nephrectomized mice (CKD mice) and control mice with LFES for 15 days. LFES prevented soleus and extensor digitorum longus muscle weight loss and loss of hind-limb muscle grip in CKD mice. LFES countered the CKD-induced decline in the IGF-1 signaling pathway and led to increases in markers of protein synthesis and myogenesis and improvement in muscle protein metabolism. In control mice, we observed an acute response phase immediately after LFES, during which the expression of inflammatory cytokines (IFN-g and IL-6) increased. Expression of the M1 macrophage marker IL-1b also increased acutely, but expression of the M2 marker arginase-1 increased 2 days after initiation of LFES, paralleling the change in IGF-1. In muscle cross-sections of LFES-treated mice, arginase-1 colocalized with IGF-1. Additionally, expression of microRNA-1 and -206, which inhibits IGF-1 translation, decreased in the acute response phase after LFES and increased at a later phase. We conclude that LFES ameliorates CKDinduced skeletal muscle atrophy by upregulation of the IGF-1 signaling pathway, which improves protein metabolism and promotes myogenesis. The upregulation of IGF-1 may be mediated by decreased expression of microRNA-1 and -206 and/or activation of M2 macrophages.

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confidence: 99%

Low-Frequency Electrical Stimulation Attenuates Muscle Atrophy in CKD—A Potential Treatment Strategy

Klein

Hassounah

et al. 2015

Journal of the American Society of Nephrology

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“…Acupuncture partially prevented skeletal muscle atrophy. This effect might be due to an increase in protein synthesis and a decrease in protein degradation [11].…”

Section: S Toda 10mentioning

confidence: 99%

Effect of Acupuncture on Carnitine for Skeletal Muscle Fatigue

Toda¹

2012

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Skeletal muscle fatigue is a common symptom in various diseases, works and exercises. These were generally induced by neuron, metabolic conditions, overused muscle, and stress. But, there have been few principles about it. Many researchers have reported that acupuncture therapy has been useful to skeletal muscle fatigue on various diseases and conditions. However, it has never been shown why acupuncture therapy has the effect on skeletal muscle fatigue. The deficiency of carnitine induces fatigue, weakness, and disorder of skeletal muscle. It has showed that acupuncture induces the increase of carnitine in skeletal muscle. These findings demonstrated that acupuncture on skeletal muscle fatigue could increase carnitine as a possible affection mechanism.

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“…Electroacupuncture increases blood flow and oxygenation of skeletal muscles 4 and has been applied for recovery from skeletal muscle fatigue and musculoskeletal disorders. Onda et al 5 showed that acupuncture with and without electrical stimulation ameliorated skeletal muscle atrophy in mice that were subjected to hind-limb suspension. Acupuncture down-regulated the genes involved in muscle breakdown (atrogin-1 and muscle RING-finger protein-1) and upregulated Akt1 and Transient receptor potential cation channel subfamily V member 4, which are positive regulators of protein synthesis.…”

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confidence: 99%

“…This was due to the greater number of dialysis treatments given in the frequently dialyzed group, as the rate of IDH per treatment was reduced. 5 Moving to a more frequent dialysis schedule is associated with a reduction in predialysis BP and a reduced need for antihypertensive medication. 5 Avoidance of the long weekend intradialytic interval is another benefit of adding more treatments per week.…”

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confidence: 99%

“…5 Moving to a more frequent dialysis schedule is associated with a reduction in predialysis BP and a reduced need for antihypertensive medication. 5 Avoidance of the long weekend intradialytic interval is another benefit of adding more treatments per week. With regard to fluid removal needs, one might achieve a considerable reduction in IDH by encouraging patients to eat less sodium, by avoiding high dialysis sodium concentrations, and by increasing weekly dialysis time.…”

mentioning

confidence: 99%

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