Activity of the investigational fluoroquinolone finafloxacin and seven other antimicrobial agents against 114 obligately anaerobic bacteria

Genzel, Gelimer H.; Stubbings, Will; Stîngu, Cătălina Suzana; Labischinski, Harald; Schaumann, Reiner

doi:10.1016/j.ijantimicag.2014.07.006

Cited by 15 publications

(4 citation statements)

References 25 publications

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“…Similar results are presented by other researchers [30,57,63]. Increasing resistance to clindamycin is observed in Europe [17,42] including Poland [26]. The results were confirmed in study covering 8 medical centres.…”

Section: Development Of Resistance To Recognisedsupporting

confidence: 90%

The Role of the Bacteroides spp. in Bacteraemia

Wysocki

Kierzkowska

Podsiadły

2022

Postępy Mikrobiologii - Advancements of Microbiology

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Anaerobic bacteraemia is not frequent (1.2–13.7%), but is associated with a high mortality rate of 16–27%. Anaerobic infections including bacteraemia nearly always arise from contamination by endogenous bacteria into contiguous or other sites like gastrointestinal tracts, genito-urinary tracts, abscesses etc. Factors leading to anaerobic bacteraemia are mainly surgical procedures, crush injuries, the presence of foreign bodies, tissue necrosis, tumours, diabetes. The most common infectious anaerobic agents are Gram-negative bacilli belonging to the Bacteroides/Parabacteroides, which under normal conditions constitute the natural human microflora. An important factor in the virulency of B. fragilis is the ability to form abscesses; a limited infection may progress to bacteraemia and then systemic inflammatory response syndrome and sepsis. Anaerobic bacteraemia mainly affects adults, with elderly patients over 65 years with underlying diseases. The importance of anaerobic bacteria in neonatal bacteraemia and sepsis is a relatively new phenomenon. In contrast the prevalence of anaerobes in bloodstream infections in children is extremely rare with children between 2 and 6 years of age having the least risk ranging 0–0.5% overall. The incidence of recovery of anaerobes in neonatal bacteraemia varies between 1.8% and 12.5%. The majority of cases reported in the literature were due to Bacteroides spp. (41%) other cultured anaerobes belonged to Clostridium spp. (32%), Peptostreptococcus spp. (20%). Blood cultures remain the gold standard for detection of the etiologic both anaerobes and aerobes agent of bloodstream infection. In recent years significant progress has been made in the methods used in the diagnosis of anaerobes, which significantly reduced the time and cost of the examination. Currently, the mass spectometry MALDI-TOF MS and 16S rRNA sequencing are increasingly used for anaerobic bacteria identification. In 2022, EUCAST published standardized disk diffusion method for the drug susceptibility testing of Bacteroides spp. and other 4 clinically significant anaerobes. Determining the sensitivity of anaerobes to antibiotics is important due to the increasing drug resistance in this group. Number of B. fragilis strains resistant to clindamycin and moxifloxacin is increasing. According to the published studies sensitivity to clindamycin and moxifloxacin is significantly rare and occurs in 64% and 68% of isolates and in 50.8% and 58.2% respectively. Carbapenems and metronidazole continue to be the most effective active antibiotics to be used in the empirical therapy of anaerobic bacteraemia. There are case reports of infections caused by multidrug-resistant strains of Bacteroides spp, meaning resistant to at least three antibiotics from different groups. Rapid microbial diagnosis, targeted therapy and surgical treatment of a possible source of infection are crucial in treatment of sepsis caused by anaerobic bacteria.

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Section: Development Of Resistance To Recognisedsupporting

confidence: 90%

The Role of the Bacteroides spp. in Bacteraemia

Wysocki

Kierzkowska

Podsiadły

2022

Postępy Mikrobiologii - Advancements of Microbiology

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“…For example, broth microdilution has been used to evaluate antimicrobial susceptibilities of the fluoroquinolone finafloxacin (57) and a novel lipopeptide antibiotic (CB-183,315) (56). The results from these studies indicated that the broth microdilution method has a good reproducibility of 100% and an agreement of 90 to 95% in comparison to agar dilution (56,57). These studies showed that the broth microdilution method is easier to perform and more convenient for clinical use than agar dilution.…”

Section: Role Of Antimicrobial Susceptibility Testing Of Clostridium mentioning

confidence: 87%

“…Some studies have used broth microdilution for C. difficile AST, which was recommended by the CLSI (52,(56)(57)(58). For example, broth microdilution has been used to evaluate antimicrobial susceptibilities of the fluoroquinolone finafloxacin (57) and a novel lipopeptide antibiotic (CB-183,315) (56).…”

Section: Role Of Antimicrobial Susceptibility Testing Of Clostridium mentioning

confidence: 99%

Update on Antimicrobial Resistance in Clostridium difficile: Resistance Mechanisms and Antimicrobial Susceptibility Testing

et al. 2017

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Oral antibiotics such as metronidazole, vancomycin and fidaxomicin are therapies of choice for infection. Several important mechanisms for antibiotic resistance have been described, including the acquisition of antibiotic resistance genes via the transfer of mobile genetic elements, selective pressure resulting in gene mutations, altered expression of redox-active proteins, iron metabolism, and DNA repair, as well as via biofilm formation. This update summarizes new information published since 2010 on phenotypic and genotypic resistance mechanisms in and addresses susceptibility test methods and other strategies to counter antibiotic resistance of .

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“…Furthermore, advanced activity was observed under anaerobic condition mainly at neutral pH value, that was verified by MIC values of finafloxacin against Gram-negative anaerob patogens including Bacteroides fragilis. It shows antibacterial effect with 0.5/4 µg/ml of MIC 50 /MIC 90 at pH 7.2 whilst these values were decreased (0.25/4 µg/ ml) under acidic conditions [9,20].…”

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confidence: 99%